O-甲基蝙蝠葛碱 | 2202-17-7

• 物质功能分类: 天然产物 - 生物碱
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 中文名称: O-甲基蝙蝠葛碱
• 英文名称: O-methyl dauricine
• 英文别名: O-methyldauricine；(1'R)-6,7,12,6'-tetramethoxy-2,2',18'-trimethyl-8,18'-seco-berbamane；(1'R)-6,7,12,6'-Tetramethoxy-2,2',18'-trimethyl-8,18'-seco-berbaman；O,O-Dimethyl-daurinolin, O-Methyl-dauricin；O,O-Dimethyl-cuspidalin；O-Methyl-dauricinine；(1R)-1-[[4-[5-[[(1R)-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-1-yl]methyl]-2-methoxyphenoxy]phenyl]methyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinoline
• CAS: 2202-17-7
• 化学式: C₃₉H₄₆N₂O₆
• 分子量: 638.804
• InChiKey: UHYCXSGUNAWVBW-CZNDPXEESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7
• 重原子数：
  47
• 可旋转键数：
  11
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  61.9
• 氢给体数：
  0
• 氢受体数：
  8

上下游信息

• 上游原料

  中文名称	英文名称	CAS号	化学式	分子量
  蝙蝠葛碱	Dauricine	524-17-4	C38H44N2O6	624.777

反应信息

• 作为产物：
  描述：

  重氮甲烷 、 蝙蝠葛碱 生成 O-甲基蝙蝠葛碱
  参考文献：
  名称：

  Dauricine production in cultured roots of Menispermum dauricum

  摘要：

  Root cultures of Menispermum dauricum were established from adventitious roots formed on the leaf segments. These roots produce dauricine as a major constituent and the optimum conditions for dauricine production in cultured roots were investigated. A dauricine content of more than 0.5% dry weight was achieved in Gamborg's B5 medium containing 3% sucrose and 7.5 mu M NAA. Tyrosine and tyramine, possible precursors of dauricine, increased dauricine formation. There was a positive correlation between dauricine content and root growth.

  DOI：

  10.1016/s0031-9422(00)89796-4

文献信息

• Tomita et al., Pharmaceutical Bulletin, 1955, vol. 3, p. 449,453
  作者：Tomita et al.

  DOI：——

  日期：——
• Inubushi; Niwa, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1952, vol. 72, p. 762,765
  作者：Inubushi、Niwa

  DOI：——

  日期：——
• Dauricine production in cultured roots of Menispermum dauricum
  作者：Yukihiro Sugimoto、Akihiko Yoshida、Shinji Uchida、Shinobu Inanaga、Yasuyuki Yamada

  DOI：10.1016/s0031-9422(00)89796-4

  日期：1994.6

  Root cultures of Menispermum dauricum were established from adventitious roots formed on the leaf segments. These roots produce dauricine as a major constituent and the optimum conditions for dauricine production in cultured roots were investigated. A dauricine content of more than 0.5% dry weight was achieved in Gamborg's B5 medium containing 3% sucrose and 7.5 mu M NAA. Tyrosine and tyramine, possible precursors of dauricine, increased dauricine formation. There was a positive correlation between dauricine content and root growth.