(10Z,12Z)-10,12-Octadecadienoic acid | 7307-45-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (10Z,12Z)-10,12-Octadecadienoic acid
• 英文别名: (10Z,12Z)-Octadeca-9,11-dienoic acid；cis-10,cis-12-octadecadienoic acid；c10,c12-Conjugated linoleic acid；octadeca-10Z,12Z-dienoic acid；cis-10,12-linoleic acid；10c, 12c-linoleic acid；10Z,12Z-octadecadienoic acid；(10Z,12Z)-octadeca-10,12-dienoic acid
• CAS: 7307-45-1
• 化学式: C₁₈H₃₂O₂
• 分子量: 280.451
• InChiKey: GKJZMAHZJGSBKD-JPDBVBESSA-N

物化性质

• 熔点：
  38.2-39.0 °C
• 沸点：
  377.7±11.0 °C(Predicted)
• 密度：
  0.8810 g/cm3(Temp: 70 °C)

计算性质

• 辛醇/水分配系数(LogP)：
  7.1
• 重原子数：
  20
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.72
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  香茅醇 、 (9Z,12Z)-octadeca-9,11-dienoic acid 、 共轭亚油酸 、 (10Z,12Z)-10,12-Octadecadienoic acid 、 共轭亚油酸 、 octadeca-11Z,13Z-dienoic acid 在 磷脂酶B 作用下， 以 水 为溶剂， 反应 0.5h， 生成 10-trans-12-cis-linoleic acid citronellol ester 、 9-cis-11-trans-linoleic acid citronellol ester
  参考文献：
  名称：

  Cla-esters

  摘要：

  公开号：

  EP1167340B1
• 作为产物：
  描述：

  10,12-二十八二炔酸 在 喹啉 、 Lindlar's catalyst 、 乙醇 作用下， 生成 (10Z,12Z)-10,12-Octadecadienoic acid
  参考文献：
  名称：

  Sparreboom, 1956, vol. 59, p. 472,473,476

  摘要：

  DOI：

文献信息

• Compositions comprising reverse isomers of conjugated linoleic acid
  申请人：Saebo Asgeir

  公开号：US20050215641A1

  公开（公告）日：2005-09-29

  The present invention relates to the field of human and animal nutrition, and in particular to certain novel compositions of conjugated linoleic acids (CLA). In particular, the present invention relates to CLA compositions comprising the c10,t12, c10,c12, t9,c11 and c9,c11 isomers of conjugated linoleic acid.

  本发明涉及人类和动物营养领域，特别是某些新颖的共轭亚油酸（CLA）组合物。具体而言，本发明涉及包含共轭亚油酸的c10,t12、c10,c12、t9,c11和c9,c11异构体的CLA组合物。
• Process
  申请人：Yan Youchan

  公开号：US20050124818A1

  公开（公告）日：2005-06-09

  A process for producing a conjugated di- or poly-unsaturated fatty acid having from 12 to 24 carbon atoms, or a salt or ester thereof, comprises reacting a non-conjugated free fatty acid, or a salt or ester thereof with a base in the presence of a solvent comprising a monohydric alcohol having from 1 to 6 carbon atoms, wherein the reaction is carried out at a temperature of from 120° C. to 200° C. in the presence of water in an amount of at least 4% by weight based on alcohol.

  生产具有12到24个碳原子的共轭二元或多元不饱和脂肪酸，或其盐或酯的方法包括在溶剂中与一种具有1到6个碳原子的一元醇反应，其中所述反应在温度为120°C至200°C的条件下进行，在水的存在下，水的含量至少为醇的重量的4%。
• Compounds that modulate fatty acid receptor activity and pet food products containing the same
  申请人：MARS, INCORPORATED

  公开号：US10827772B2

  公开（公告）日：2020-11-10

  A flavor composition comprising at least one compound that modulates, increases and/or enhances the activity of a GPR120 fatty acid receptor that can be used to enhance the fatty acid taste and/or palatability of pet food products is described herein. Also disclosed herein are methods for identifying said compounds.

  本文描述了一种风味组合物，该组合物包含至少一种可调节、增加和/或增强 GPR120 脂肪酸受体活性的化合物，可用于增强宠物食品的脂肪酸味道和/或适口性。本文还公开了鉴定所述化合物的方法。
• Methods and compositions for treating diabetes
  申请人：Vanden Heuvel P. John

  公开号：US20050282897A1

  公开（公告）日：2005-12-22

  Methods of treating diabetes in an animal and food compositions useful for treating diabetes are described. In one aspect of the invention, the method includes treating the animal with a therapeutically effective amount of CLA including 9,11-octadecadienoic acid and 10,12-octadecadienoic acid, isomers thereof, esters thereof, salts thereof or mixtures thereof. In another aspect of the invention, a food composition comprising a food product having a therapeutically effective amount of a purified CLA isomer, including cis,cis-9,11-octadecadienoic acid, trans,cis-10,12-octadecadienoic acid or a mixture of purified cis,trans-9,11-ocatadecadienoic acid and trans,cis-0,11-octadecadienoic acid is described.

  本发明描述了治疗动物糖尿病的方法和用于治疗糖尿病的食品组合物。在本发明的一个方面，该方法包括用治疗有效量的 CLA（包括 9,11-十八碳二烯酸和 10,12-十八碳二烯酸）、其异构体、其酯、其盐或其混合物治疗动物。在本发明的另一方面，描述了一种食品组合物，该组合物包含具有治疗有效量的纯化CLA异构体的食品，包括顺式、顺式-9,11-十八碳二烯酸、反式、顺式-10,12-十八碳二烯酸或纯化的顺式、反式-9,11-十八碳二烯酸和反式、顺式-0,11-十八碳二烯酸的混合物。
• A simple method of preparation of methyl<i>trans</i>-10,<i>cis</i>-12- and<i>cis</i>-9,<i>trans</i>-11-octadecadienoates from methyl linoleate
  作者：O. Berdeaux、L. Voinot、E. Angioni、P. Juanéda、J. L. Sébédio

  DOI：10.1007/s11746-998-0327-x

  日期：1998.12

  AbstractPure conjugated isomers of linoleic acid were prepared on a large scale by alkali‐isomerization of purified methyl linoleate. The methyl esters of alkali‐isomerized linoleic acid contained mainly the methyl cis‐9,trans‐11‐ and trans‐10,cis‐12‐octadecadienoates (44 and 47%, respectively). These two isomers were then separated and purified by a series of low‐temperature crystallizations from acetone. The isomeric purity obtained for the cis‐9,trans‐11‐octadecadienoate isomer was >90% and that of the trans‐10,cis‐12‐octadecadienoate isomer was 89 to 97%. The isolated yield of the two isomers corresponded to 18 and 25.7%, respectively, of the starting material. The structure of the two isomers was confirmed using partial hydrazine reduction, silver nitrate‐thin‐layer chromatography of the resulting monoenes and gas chromatography coupled with mass spectrometry of the 4,4‐dimethyloxazoline derivatives. Fourier transform infrared spectroscopy of the monoenes gave the confirmation of the geometry of each double bond.