3-(3-氯苯基)丙酸 | 21640-48-2

• 物质功能分类: 化学试剂 - 有机试剂 - 芳香酸
• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 苯丙酸
• 中文名称: 3-(3-氯苯基)丙酸
• 中文别名: 间氯苯丙酸
• 英文名称: 3-chlorohydrocinnamic acid
• 英文别名: 3-(3-chlorophenyl)propanoic acid
• CAS: 21640-48-2
• 化学式: C₉H₉ClO₂
• mdl: MFCD01310801
• 分子量: 184.622
• InChiKey: CLTDVBQNUHHYCA-UHFFFAOYSA-N

物化性质

• 熔点：
  72-76 °C (lit.)
• 沸点：
  263.86°C (rough estimate)
• 密度：
  1.1989 (rough estimate)
• 稳定性/保质期：

  按规定使用和贮存的不会分解，避氧化剂。

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.222
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 危险等级：
  IRRITANT
• 危险品标志：
  Xn
• 安全说明：
  S26,S39
• 危险类别码：
  R22,R41,R43
• WGK Germany：
  3
• 海关编码：
  2916399090
• 危险性防范说明：
  P280,P305+P351+P338,P310
• 危险性描述：
  H302,H315,H319,H332,H335
• 储存条件：
  请将药品存放在密闭、阴凉、干燥的地方。

SDS

Material Safety Data Sheet

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Section 1. Identification of the substance
Product Name: 3-(3-Chlorophenyl)propanoic acid
Synonyms:

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Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.
H302: Harmful if swallowed
H317: May cause an allergic skin reaction
H318: Causes serious eye damage
P280: Wear protective gloves/protective clothing/eye protection/face protection
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present
and easy to do – continue rinsing

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Section 3. Composition/information on ingredients.
Ingredient name: 3-(3-Chlorophenyl)propanoic acid
CAS number: 21640-48-2

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Section 4. First aid measures
Skin contact: Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
Eye contact:
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

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Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

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Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

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Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Storage: Store in closed vessels.

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Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

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Section 9. Physical and chemical properties
Appearance: Not specified
No data
Boiling point:
Melting point: No data
Flash point: No data
Density: No data
Molecular formula: C9H9ClO2
Molecular weight: 184.6

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Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, hydrogen chloride.

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Section 11. Toxicological information
No data.

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Section 12. Ecological information
No data.

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Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

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Section 14. Transportation information
Non-harzardous for air and ground transportation.

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Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

制备方法与用途

化学性质：白色结晶，熔点为77°C至78°C。

反应信息

• 作为反应物：
  描述：

  3-(3-氯苯基)丙酸 在 sodium hydroxide 、 lithium aluminium tetrahydride 、 氯化亚砜 、 乙醚 、 苯基锂 、 二乙胺 作用下， 生成 1-甲基-1,2,3,4-四氢喹啉
  参考文献：
  名称：

  Huisgen; Koenig, Chemische Berichte, 1959, vol. 92, p. 203,211

  摘要：

  DOI：
• 作为产物：
  描述：

  乙基3-(3-氯苯基)丙酸酯 在 sodium hydroxide 作用下， 反应 3.0h， 以143.2 g的产率得到3-(3-氯苯基)丙酸
  参考文献：
  名称：

  一种茚酮类化合物的制备方法

  摘要：

  本发明涉及有机合成领域，特别是涉及一种茚酮类化合物的制备方法。本发明提供一种茚酮类化合物的制备方法，包括：1）将式I化合物与式II化合物进行缩合反应，制备获得式III化合物；2）将式III化合物在碱存在的条件下水解，制备获得式IV化合物；3）将式IV化合物酰化、关环，制备获得式V化合物。本发明所提供的茚酮类化合物的制备方法与现有技术相比，具有原料成本低、操作简便、三废少、收率高等优点，更适合工业化生产，相对于现有技术中的各种茚酮类化合物的制备方法优势明显，具有良好的产业化前景。

  公开号：

  CN108329197A

文献信息

• Design, synthesis and anticancer activity of N-(1-(4-(dibenzo[b,f][1,4]thiazepin-11-yl)piperazin-1-yl)-1-oxo-3-phenylpropan-2-yl derivatives
  作者：Mura Reddy Gudisela、N. Srinivasu、Chaitanya Mulakayala、Praveen Bommu、M.V. Basaveswara Rao、Naveen Mulakayala

  DOI：10.1016/j.bmcl.2017.07.029

  日期：2017.9

  Novel N-(1-(4-(dibenzo[b,f][1,4]thiazepin-11-yl)piperazin-1-yl)-1-oxo-3-phenylpropan-2-yl derivatives were designed, synthesized and their chemical structures were confirmed by 1H NMR, 13C NMR and Mass spectra. The anticancer activities of the newly synthesized compounds were evaluated in vitro against three human cancer cell lines including K562, Colo-205 and MDA-MB 231 by MTT assay. The screening

  设计，合成了新型的N-（1-（4-（二苯并[ b，f ] [1,4]噻嗪pin-11-基）哌嗪-1-基）-1-氧代-3-苯基丙烷-2-基衍生物并通过1 H NMR，13 C NMR和质谱证实了它们的化学结构，并通过MTT法体外评估了新合成的化合物对三种人类癌细胞株K562，Colo-205和MDA-MB 231的抗癌活性。筛选结果表明，5种化合物（16b，16d，16i，16p和16q）表现出强烈的细胞毒性活性，IC 50为50。值介于20和40μM之间。进一步的体外研究表明，抑制沉默调节蛋白可能是这些分子起作用的可能机制。
• Sulfonamides
  申请人：Galley Guido

  公开号：US20060014945A1

  公开（公告）日：2006-01-19

  The invention relates to compounds of the general formula in which R 1 , R 2 , R3, R 4 , R 2′ , R3′, R 4′ , R 5 , and X is —CHR— are as defined in the specification. The invention also provides pharmaceutically acceptable acid addition salts, optically pure enantiomers, racemates and diastereomeric mixtures of such compounds. The invention further provides methods for the treatment of Alzheimer's disease or common cancers.

  该发明涉及一般式化合物，其中R1、R2、R3、R4、R2'、R3'、R4'、R5和X为规范中定义的—CHR—。该发明还提供药学上可接受的酸盐加合物，光学纯对映体，外消旋体和这类化合物的二对映异构体混合物。该发明还提供治疗阿尔茨海默病或常见癌症的方法。
• 1,2-Dibromoethane and KI mediated α-acyloxylation of ketones with carboxylic acids
  作者：Xujie Wang、Gangsheng Li、Yanan Yang、Jianshuang Jiang、Ziming Feng、Peicheng Zhang

  DOI：10.1016/j.cclet.2019.08.052

  日期：2020.3

  Abstract The 1,2-dibromoethane- and KI-mediated α-acyloxylation of ketones is reported in moderate to good yield without the use of transition metals and strong oxidants. Various acids are well tolerated with wide functional group compatibility. An 1,2-dibromoethane- and KI-catalysed reaction mechanism is proposed based on the results of control experiments.

  摘要据报道，在不使用过渡金属和强氧化剂的情况下，酮的1,2-二溴乙烷和KI介导的α-酰氧基化反应具有中等至良好的收率。各种酸均具有良好的耐受性，并具有广泛的官能团相容性。根据控制实验结果，提出了1,2-二溴乙烷和KI催化的反应机理。
• [EN] SUBSTITUTED MORPHOLINE AND THIOMORPHOLINE DERIVATIVES<br/>[FR] DÉRIVÉS DE MORPHOLINE ET DE THIOMORPHOLINE SUBSTITUÉS
  申请人：LUNDBECK & CO AS H

  公开号：WO2005087754A1

  公开（公告）日：2005-09-22

  The present invention relates to morpholine and thiomorpholine derivatives of the general formula I or pharmaceutically acceptable salts thereof and their use.

  本发明涉及一般式I的吗啉和硫代吗啉衍生物或其药用盐及其用途。
• Direct β-Selective Hydrocarboxylation of Styrenes with CO₂ Enabled by Continuous Flow Photoredox Catalysis
  作者：Hyowon Seo、Aofei Liu、Timothy F. Jamison

  DOI：10.1021/jacs.7b05942

  日期：2017.10.11

  The direct β-selective hydrocarboxylation of styrenes under atmospheric pressure of CO2 has been developed using photoredox catalysis in continuous flow. The scope of this methodology was demonstrated with a range of functionalized terminal styrenes, as well as α-substituted and β-substituted styrenes.

  已经在连续流动中使用光氧化还原催化开发了在 CO2 大气压下苯乙烯的直接 β-选择性加氢羧化反应。该方法的范围通过一系列官能化的末端苯乙烯以及 α-取代和 β-取代的苯乙烯进行了证明。