苯基丙酮酸缩氨基脲 | 81118-82-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 苯丙酸
• 中文名称: 苯基丙酮酸缩氨基脲
• 英文名称: phenyl pyruvic acid semicarbazone
• 英文别名: Phenylbrenztraubensaeuresemicarbazon；Phenylpyruvic acid semicarbazone；2-(carbamoylhydrazinylidene)-3-phenylpropanoic acid
• CAS: 81118-82-3
• 化学式: C₁₀H₁₁N₃O₃
• 分子量: 221.216
• InChiKey: YJGYBVXMGQWGRT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  105
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  苯基丙酮酸缩氨基脲 在 镍 作用下， 生成 3-phenyl-2-semicarbazido-propionic acid
  参考文献：
  名称：

  Chabrier; Sekera, Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1948, vol. 226, p. 818

  摘要：

  DOI：
• 作为产物：
  描述：

  苯丙酮酸 、 盐酸氨基脲 在 sodium acetate 作用下， 以 乙醇 、 水 为溶剂， 生成 苯基丙酮酸缩氨基脲
  参考文献：
  名称：

  Shawney, G. L.; Baijal, J. S.; Chandra, S., Acta Chimica Academiae Scientiarum Hungaricae, 1981, vol. 108, # 4, p. 325 - 332

  摘要：

  DOI：

文献信息

• Manganese(II) and copper(II) complexes of some nitrogenoxygen and nitrogensulphur donor ligands
  作者：S. Chandra、K.K. Sharma

  DOI：10.1016/s0277-5387(00)84657-4

  日期：1984.1

  Abstract Manganese(II) and copper(II) complexes of the type M(ligandH)2 with some nitrogenoxygen and nitrogensulphur donor ligands (HL) viz. phenylpyruvic acid semicarbazone (ppysc), 4-methylphenylpyruvic acid semicarbazone (4-mppysc), phenylpyruvic acid thiosemicarbazone (ppytsc) and 4-methylphenyl pyruvic acid thiosemicarbazone (4-ppytsc), have been synthesised. All the complexes have been characterised

  摘要M（配体H）2型锰（II）和铜（II）配合物具有一些氮氧和氮硫供体配体（HL）。已经合成了苯基丙酮酸半卡巴zone（ppysc），4-甲基苯基丙酮酸半卡巴zone（4-mppysc），苯基丙酮酸硫代半碳酰胺（ppytsc）和4-甲基苯基丙酮酸硫代半碳zone（4-ppytsc）。所有配合物的特征都在于磁矩测量，红外电子和电子自旋共振的特殊研究。所有的配体表现为三齿的。
• Synthesis of Some 5-Alkyl-6-azauracils¹
  作者：PAULINE K. CHANG

  DOI：10.1021/jo01106a038

  日期：1958.12
• Synthesis and antimicrobial evaluation of 6-azauracil non-nucleosides
  作者：Nasser R. El-Brollosy

  DOI：10.1007/s00706-008-0948-7

  日期：2008.12

  The present study describes synthesis and antimicrobial evaluation of a series of novel 6-azauracil non-nucleosides. Reaction of silylated 6-azauracils with the appropriate chloroethers gave the corresponding non-nucleosides. 1-(Allyloxymethy)6-azauracils and non-nucleosides bearing indanyl, cyclohexenyl, and cyclohexyl moieties were obtained via silylation of 6-azauracils followed by treatment with the appropriate acetals. Selected compounds were tested for their in vitro antimicrobial activity against a panel of standard strains of Gram-positive and Gram-negative bacteria and the yeast-like pathogenic fungus Candida albicans. Four compounds showed marked inhibitory activity particularly against the tested Gram-positive bacteria.
• Synthetic and Antiviral Studies on Certain Acyclic Nucleosides of 5-Benzyl-6-Azauracil Derivatives
  作者：Yeh-Long Chen、Shwu-Jing Chen、Kuan-Han Lee、Bor-Ruey Huang、Cherng-Chyi Tzeng

  DOI：10.1080/07328319308018563

  日期：1993.11

  Several 5-(4-substituted benzyl)-6-azauracils have been synthesized from the corresponding benzaldehydes. The 5-benzyl-6-azauracils were silylated with hexamethyldisilazane and then glycosylated with aliphatic halides, e.g., (2-acetoxyethoxy)methyl bromide and 1,3-dibenzyloxy-2-chloromethoxypropane, to give protected acyclic nucleosides which were deprotected to afford acyclonucleosides of 5-(4-substituted benzyl)-6-azauracils. None of the compounds exhibited significant antiviral activity against herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) in vitro.
• Stoermer; Kirchner, Chemische Berichte, 1920, vol. 53, p. 1299
  作者：Stoermer、Kirchner

  DOI：——

  日期：——