Manganese(II) and copper(II) complexes of some nitrogenoxygen and nitrogensulphur donor ligands
作者:S. Chandra、K.K. Sharma
DOI:10.1016/s0277-5387(00)84657-4
日期:1984.1
Abstract Manganese(II) and copper(II) complexes of the type M(ligandH)2 with some nitrogenoxygen and nitrogensulphur donor ligands (HL) viz. phenylpyruvic acid semicarbazone (ppysc), 4-methylphenylpyruvic acid semicarbazone (4-mppysc), phenylpyruvic acid thiosemicarbazone (ppytsc) and 4-methylphenyl pyruvic acid thiosemicarbazone (4-ppytsc), have been synthesised. All the complexes have been characterised
Synthesis of Some 5-Alkyl-6-azauracils<sup>1</sup>
作者:PAULINE K. CHANG
DOI:10.1021/jo01106a038
日期:1958.12
Synthesis and antimicrobial evaluation of 6-azauracil non-nucleosides
作者:Nasser R. El-Brollosy
DOI:10.1007/s00706-008-0948-7
日期:2008.12
The present study describes synthesis and antimicrobial evaluation of a series of novel 6-azauracil non-nucleosides. Reaction of silylated 6-azauracils with the appropriate chloroethers gave the corresponding non-nucleosides. 1-(Allyloxymethy)6-azauracils and non-nucleosides bearing indanyl, cyclohexenyl, and cyclohexyl moieties were obtained via silylation of 6-azauracils followed by treatment with the appropriate acetals. Selected compounds were tested for their in vitro antimicrobial activity against a panel of standard strains of Gram-positive and Gram-negative bacteria and the yeast-like pathogenic fungus Candida albicans. Four compounds showed marked inhibitory activity particularly against the tested Gram-positive bacteria.
Synthetic and Antiviral Studies on Certain Acyclic Nucleosides of 5-Benzyl-6-Azauracil Derivatives
Several 5-(4-substituted benzyl)-6-azauracils have been synthesized from the corresponding benzaldehydes. The 5-benzyl-6-azauracils were silylated with hexamethyldisilazane and then glycosylated with aliphatic halides, e.g., (2-acetoxyethoxy)methyl bromide and 1,3-dibenzyloxy-2-chloromethoxypropane, to give protected acyclic nucleosides which were deprotected to afford acyclonucleosides of 5-(4-substituted benzyl)-6-azauracils. None of the compounds exhibited significant antiviral activity against herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) in vitro.
Stoermer; Kirchner, Chemische Berichte, 1920, vol. 53, p. 1299