The invention provides a process for the preparation of a sartan derivative of formula (I) (formula as filed in paper form) (I) wherein the substituents have the meaning indicated in the description, or a pharmaceutically acceptable salt thereof, comprising reacting 2-cyanophenylboronic acid or a derivative thereof with a p-halobenzyl-1H-imidazole derivative of formula (VI), (formula as filed in paper form) (VI) wherein (part of formula as filed in paper form), X, Y, R
1
and R
2
are as defined above, and Z is I, Br or Cl, in the presence of a transition metal catalyst and an inorganic or organic base. The invention also provides new intermediates of formula (V), (formula as filed in paper form) (V) wherein M is an alkali metal or an NR
4
R
5
R
6
R
7
group; and of formula (II) (formula as filed in paper form) (II)
本发明提供了一种制备式(I)(纸质文件中的公式)的Sartan衍
生物或其药学上可接受的盐的方法,其中取代基具有说明书中指示的含义,包括在过渡
金属催化剂和无机或有机碱的存在下,将2-
氰基苯
硼酸或其衍
生物与式(VI)(纸质文件中的公式)的p-卤苯基-
1H-咪唑衍
生物反应,其中(公式的一部分如纸质文件中所示),X、Y、R1和R2如上定义,Z为I、Br或Cl。本发明还提供了式(V)(纸质文件中的公式)的新中间体,其中M是碱
金属或NR4R5R6R7基团;以及式(II)(纸质文件中的公式)的新中间体。