[(1S,2R,7R,8R,9R,11R,13R,14R)-8-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-1,5,7,9,11,13-hexamethyl-4,6,12,16-tetraoxo-3,17-dioxa-15-azabicyclo[12.3.0]heptadecan-9-yl] carbamate | 764661-57-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: [(1S,2R,7R,8R,9R,11R,13R,14R)-8-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-1,5,7,9,11,13-hexamethyl-4,6,12,16-tetraoxo-3,17-dioxa-15-azabicyclo[12.3.0]heptadecan-9-yl] carbamate
• CAS: 764661-57-6
• 化学式: C₃₁H₅₁N₃O₁₁
• 分子量: 641.759
• InChiKey: YBVXCIFBRBBAEU-GMCWFBMUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  45
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.84
• 拓扑面积：
  193
• 氢给体数：
  3
• 氢受体数：
  12

反应信息

• 作为反应物：
  描述：

  [(1S,2R,7R,8R,9R,11R,13R,14R)-8-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-1,5,7,9,11,13-hexamethyl-4,6,12,16-tetraoxo-3,17-dioxa-15-azabicyclo[12.3.0]heptadecan-9-yl] carbamate 在 三氟乙酸 、 肼 作用下， 以 乙腈 为溶剂， 生成
  参考文献：
  名称：

  Synthesis and antibacterial activity of C6-carbazate ketolides

  摘要：

  A novel series of ketolides containing heteroaryl groups that are linked to the erythronolide ring via a C6-carbazate functionality has been successfully synthesized. Careful modulation of the heteroaryl groups, the length and degree of saturation of the C6-carbazate linker, and the substituents present on each of the carbazate nitrogens led to compounds with potent activity against key bacterial respiratory pathogens. The best analogs of this series had in vitro and in vivo (sc dosing) profiles that were comparable to telithromycin. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.09.036
• 作为产物：
  描述：

  红霉素 在 盐酸 、 甲醇 、 4-二甲氨基吡啶 、 水 、 sodium hexamethyldisilazane 、 三氟乙酸吡啶 、 二甲基亚砜 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 三乙胺 作用下， 以 四氢呋喃 、 甲醇 、 乙醇 、 二氯甲烷 为溶剂， 反应 97.0h， 生成 [(1S,2R,7R,8R,9R,11R,13R,14R)-8-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-1,5,7,9,11,13-hexamethyl-4,6,12,16-tetraoxo-3,17-dioxa-15-azabicyclo[12.3.0]heptadecan-9-yl] carbamate
  参考文献：
  名称：

  C-6氨基甲酸酯酮化物（一种新型口服活性酮化物抗生素）的合成和抗菌活性。

  摘要：

  据报道，有一系列新的抗菌酮醇化物，其特征在于使用C-6氨基甲酸酯将芳烷基侧链束缚在大环内酯核心上。该系列的最佳成员在体外和体内的活性均与泰利霉素相当。对于该系列，在先前报道的酮醇化物中未观察到的C-2部分差向异构体被注意到。

  DOI：

  10.1016/j.bmcl.2004.06.045

文献信息

• Synthesis and antibacterial activity of C-6 carbamate ketolides, a novel series of orally active ketolide antibiotics
  作者：Todd C. Henninger、Xiaodong Xu、Darren Abbanat、Ellen Z. Baum、Barbara D. Foleno、Jamese J. Hilliard、Karen Bush、Dennis J. Hlasta、Mark J. Macielag

  DOI：10.1016/j.bmcl.2004.06.045

  日期：2004.9

  antibacterial ketolides is reported, which features the use of a C-6 carbamate for tethering the arylalkyl sidechain to the macrolide core. The best members of this series display in vitro and in vivo activity comparable to telithromycin. Partial epimerization at C-2, unobserved in previously reported ketolides, was noted for this series.

  据报道，有一系列新的抗菌酮醇化物，其特征在于使用C-6氨基甲酸酯将芳烷基侧链束缚在大环内酯核心上。该系列的最佳成员在体外和体内的活性均与泰利霉素相当。对于该系列，在先前报道的酮醇化物中未观察到的C-2部分差向异构体被注意到。
• Synthesis and antibacterial activity of C6-carbazate ketolides
  作者：Manomi A. Tennakoon、Todd C. Henninger、Darren Abbanat、Barbara D. Foleno、Jamese J. Hilliard、Karen Bush、Mark J. Macielag

  DOI：10.1016/j.bmcl.2006.09.036

  日期：2006.12

  A novel series of ketolides containing heteroaryl groups that are linked to the erythronolide ring via a C6-carbazate functionality has been successfully synthesized. Careful modulation of the heteroaryl groups, the length and degree of saturation of the C6-carbazate linker, and the substituents present on each of the carbazate nitrogens led to compounds with potent activity against key bacterial respiratory pathogens. The best analogs of this series had in vitro and in vivo (sc dosing) profiles that were comparable to telithromycin. (c) 2006 Elsevier Ltd. All rights reserved.