/SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on the left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Poisons A and B/
/SRP:/ Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Cover skin burns with dry sterile dressings after decontamination ... . /Poisons A and B/
来源:Hazardous Substances Data Bank (HSDB)
毒理性
解毒与急救
/SRP:/ 高级治疗：对于无意识、严重肺水肿或严重呼吸困难的病人，考虑进行口咽或鼻咽气管插管以控制气道。使用气囊面罩装置的正压通气技术可能有益。考虑使用药物治疗肺水肿……。对于严重的支气管痉挛，考虑给予β激动剂，如沙丁胺醇……。监测心率和必要时治疗心律失常……。开始静脉输注D5W /SRP: "保持开放"，最低流量/。如果出现低血容量的迹象，使用0.9%生理盐水（NS）或乳酸林格氏液。对于伴有低血容量迹象的低血压，谨慎给予液体。注意液体过载的迹象……。使用地西泮或劳拉西泮治疗癫痫……。使用丙美卡因氢氯化物协助眼部冲洗……。 /Poisons A and B/
/SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag valve mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Consider administering a beta agonist such as albuterol for severe bronchospasm ... . Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam or lorazepam ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Poisons A and B/
/LABORATORY ANIMALS: Subchronic or Prechronic Exposure/ Halofenozide (RH-70,345, purity: 91.7%), moistened with tap water, was applied to the shaved skin of 10 Crl:CD BR rat/sex/dose level at concentrations of 0, 40, 200, or 1000 mg/kg for 6 hrs/day 5 days/week for 13 weeks using an occlusive wrap. No treatment-related mortalities occurred. No treatment-related clinical signs were observed. Statistically significant decreases in mean red blood cell, hemoglobin, and hematocrit levels and statistically significant increases in mean methemoglobin levels in both males and females at 1000 mg/kg were observed. A statistically significant and dose-related increase in mean relative liver weights was observed in both males and females at 200 and 1000 mg/kg. Microscopic examination revealed increased pigment (hemosiderin) in the liver (Kupffer cells) and spleen in males (200 and 1000 mg/kg) and females (1000 mg/kg) and centrilobular to midzonal hepatocellular hypertrophy in both males and females at 200 and 1000 mg/kg. No adverse effects. NOEL (systemic, M/F)=40 mg/kg/day (based on increased mean relative liver weights). NOEL (dermal, M/F)=1000 mg/kg (no treatment-related skin effects).
/LABORATORY ANIMALS: Subchronic or Prechronic Exposure/Halofenozide (RH-70,345, purity: 91.7%) was admixed to the feed at concentrations of 0, 30, 100, 300, or 1000 ppm and fed to 4 beagle dogs/sex/dose level daily for a period of 15 weeks. No animals died during the study. No treatment-related clinical signs were observed. Statistically significant decreases in mean red blood cell, hemoglobin, and hematocrit levels, statistically significant increases in mean platelet, reticulocyte, and methemoglobin levels, and incidences of Heinz bodies were observed in both males and females at 1000 ppm. Microscopic examination revealed slight to moderate hemosiderin in the cytoplasm of Kupffer cells of liver and in the cytoplasm of fixed macrophages in red pulp of spleen and minimal to moderate erythroid hyperplasia in bone marrow in both males and females at 300 and 1000 ppm. No adverse effects. NOEL (M)=3.7 mg/kg/day (100 ppm) and (F)=4.0 mg/kg/day (100 ppm) (based on histopathology-slight to moderate hemosiderin in the cytoplasm of Kupffer cells of liver and in the cytoplasm of fixed macrophages in red pulp of spleen and minimal to moderate erythroid hyperplasia in bone marrow).
[EN] ACC INHIBITORS AND USES THEREOF<br/>[FR] INHIBITEURS DE L'ACC ET UTILISATIONS ASSOCIÉES
申请人：GILEAD APOLLO LLC
公开号：WO2017075056A1
公开（公告）日：2017-05-04
The present invention provides compounds I and II useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, and methods of using the same.
[EN] BICYCLYL-SUBSTITUTED ISOTHIAZOLINE COMPOUNDS<br/>[FR] COMPOSÉS ISOTHIAZOLINE SUBSTITUÉS PAR UN BICYCLYLE
申请人：BASF SE
公开号：WO2014206910A1
公开（公告）日：2014-12-31
The present invention relates to bicyclyl-substituted isothiazoline compounds of formula (I) wherein the variables are as defined in the claims and description. The compounds are useful for combating or controlling invertebrate pests, in particular arthropod pests and nematodes. The invention also relates to a method for controlling invertebrate pests by using these compounds and to plant propagation material and to an agricultural and a veterinary composition comprising said compounds.
The present invention relates to azoline compounds of formula (I) wherein A, B1, B2, B3, G1, G2, X1, R1, R3a, R3b, Rg1 and Rg2 are as defined in the claims and the description. The compounds are useful for combating or controlling invertebrate pests, in particular arthropod pests and nematodes. The invention also relates to a method for controlling invertebrate pests by using these compounds and to plant propagation material and to an agricultural and a veterinary composition comprising said compounds.
