D-色氨酸 | 6536-35-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 中文名称: D-色氨酸
• 英文名称: oxindolyl-L-alanine
• 英文别名: 3h-Indole-3-propanoic acid,a-amino-；2-amino-3-(3H-indol-3-yl)propanoic acid
• CAS: 6536-35-2
• 化学式: C₁₁H₁₂N₂O₂
• 分子量: 204.228
• InChiKey: RDTOURARQPNLFK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.2
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  75.7
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  D-色氨酸 在 sodium hydroxide 、 air 作用下， 反应 12.0h， 生成 (3S)-3-hydroxyoxytryptophan
  参考文献：
  名称：

  Preparative separation of the diastereoisomers of dioxindolyl-L-alanine and assignment of stereochemistry at C-3

  摘要：

  DOI：

  10.1021/jo00303a027
• 作为产物：
  描述：

  2-氯-6-硝基甲苯 在 镍 磷化氢 、 sodium hydroxide 、 氢碘酸 、 氢气 、 乙酸酐 、 三氯氧磷 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 25.0~120.0 ℃ 、10.34 MPa 条件下， 反应 165.25h， 生成 D-色氨酸
  参考文献：
  名称：

  S-4-chlorotryptophan: Its synthesis via resolution, determination of the absolute stereochemistry and identification in the crude seed protein of the pea, pisum sativum

  摘要：

  DOI：

  10.1016/s0040-4039(00)86054-2

文献信息

• Iyengar, R. R.; Bhattacharya, P. K., Indian Journal of Chemistry, Section A: Inorganic, Physical, Theoretical and Analytical, 1989, vol. 28, # 6, p. 445 - 451
  作者：Iyengar, R. R.、Bhattacharya, P. K.

  DOI：——

  日期：——
• PROCESS FOR PURIFICATION OF IMMUNOGLOBULINS USING A PSEUDOBIOAFFINITY ADSORBENT
  申请人：Lali Arvind Mallinath

  公开号：US20100113746A1

  公开（公告）日：2010-05-06

  The present invention relates to the development of pseudobioaffinity adsorbent and process for purification of immunoglobulin G from immunoglobulin containing solutions such as but not limited to plasma, serum, cell culture supernatant, ascites fluids. The adsorbent consists of a solid support and ligand. The ligand may be attached to the matrix or be part of matrix. The ligand is selected from a group of hydrophobic amino acids such as alanine, valine, leucine, isoleucine, proline, phenylalanine, tryptophan and tyrosine and the support material being preferably a synthetic hydrophilic polymer of methacrylate or acrylate species, or any of its derivatives. The adsorbent is cheap and stable to harsh conditions such as 1.0 M NaOH used during regeneration of adsorbents. Moreover there is no problem of toxic leachables typically associated with biological ligands. The nature of the adsorbent also allows high flow rate operations at relatively low pressures. The process includes adjusting the pH and conductivity of the feed solution and the use of ionic salts and additives such as polyols or alcohols for eluting the bound IgG.
• US7323328B2
  申请人：——

  公开号：US7323328B2

  公开（公告）日：2008-01-29
• Preparative separation of the diastereoisomers of dioxindolyl-L-alanine and assignment of stereochemistry at C-3
  作者：Rita B. Labroo、Louis A. Cohen

  DOI：10.1021/jo00303a027

  日期：1990.8
• S-4-chlorotryptophan: Its synthesis via resolution, determination of the absolute stereochemistry and identification in the crude seed protein of the pea, pisum sativum
  作者：S.V. Thiruvikraman、Youji Sakagami、Masato Katayama、Shingo Marumo

  DOI：10.1016/s0040-4039(00)86054-2

  日期：——