2',6'-dimethyl 4'-benzyloxycarbonylphenyl-2,7-dimethoxy-acridine-9-carboxylate | 676160-98-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2',6'-dimethyl 4'-benzyloxycarbonylphenyl-2,7-dimethoxy-acridine-9-carboxylate
• 英文别名: 2',6'-dimethyl-4'-benzyloxycarbonylphenyl-2,7-dimethoxy-acridine-9-carboxylate；(2,6-Dimethyl-4-phenylmethoxycarbonylphenyl) 2,7-dimethoxyacridine-9-carboxylate
• CAS: 676160-98-8
• 化学式: C₃₂H₂₇NO₆
• 分子量: 521.569
• InChiKey: WMDJKCPTRMVAOQ-UHFFFAOYSA-N

物化性质

• 沸点：
  739.3±60.0 °C(Predicted)
• 密度：
  1.261±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  7
• 重原子数：
  39
• 可旋转键数：
  9
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  84
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  2',6'-dimethyl 4'-benzyloxycarbonylphenyl-2,7-dimethoxy-acridine-9-carboxylate 、 三氟甲烷磺酸甲酯 在 碳酸氢钠 作用下， 以 二氯甲烷 为溶剂， 反应 16.0h， 生成 2',6'-dimethyl 4'-benzyloxycarbonylphenyl-2,7-dimethoxy-10-methylacridinium-9-carboxylate
  参考文献：
  名称：

  Novel applications of acridinium compounds and derivatives in homogeneous assays

  摘要：

  公开号：

  EP1403254B1
• 作为产物：
  描述：

  2,7-dimethoxy acridine-9-carboxylic acid 、 4-carboxybenzyl-2,6-dimethylphenol 在 吡啶 、 对甲苯磺酰氯 、 苯酚 作用下， 反应 50.17h， 以72%的产率得到2',6'-dimethyl 4'-benzyloxycarbonylphenyl-2,7-dimethoxy-acridine-9-carboxylate
  参考文献：
  名称：

  Novel applications of acridinium compounds and derivatives in homogeneous assays

  摘要：

  公开号：

  EP1403254B1

文献信息

• High quantum yield acridinium compounds and their uses in improving assay sensitivity
  申请人：Natrajan Anand

  公开号：US20050221390A1

  公开（公告）日：2005-10-06

  The present invention relates to hydrophilic, high quantum yield acridinium compounds. It has been discovered that the placement of electron-donating groups in the acridinium ring system increases the amount of light that is emitted by the corresponding acridinium compound when its chemiluminescence is triggered by alkaline peroxide. More specifically, it has been found that the placement of one or two hydrophilic, alkoxy groups at the C-2 and/or C-7 position of the acridinium ring system of acridinium compounds increases their quantum yield and enhances the aqueous solubility of these compounds. The present hydrophilic, high quantum yield, acridinium compounds are useful chemiluminescent labels for improving the sensitivity of immunoassays.

  本发明涉及亲水性高、量子产率高的吖啶化合物。已经发现，在吖啶环系统中引入电子供体基团可以增加相应吖啶化合物在碱性过氧化物触发化学发光时发射的光量。更具体地说，已经发现，在吖啶化合物的吖啶环系统的C-2和/或C-7位置引入一个或两个亲水性的烷氧基团可以增加它们的量子产率并增强这些化合物的水溶性。本发明的亲水性高、量子产率高的吖啶化合物可用作化学发光标记物，以提高免疫测定的灵敏度。
• Novel Applications of Acridinium Compounds and Derivatives in Homogeneous Assays
  申请人：Natrajan Anand A.

  公开号：US20090029349A1

  公开（公告）日：2009-01-29

  Chemiluminescent acridinium compounds are used in homogeneous assays to determine the concentration of an analyte in a sample without strong acid or strong base treatment. The chemiluminescent acridinium compounds include acridinium esters with electron donating functional groups at the C2 and/or C7 position on the acridinium nucleus to inhibit pseudo-base formation, or acridinium sulfonamides with or without electron donating functional groups at the C2 and/or C7 position on the acridinium nucleus.

  化学发光的吖啶化合物被用于均相分析中，以测定样品中分析物的浓度，而无需使用强酸或强碱处理。这些化学发光的吖啶化合物包括在吖啶核上具有电子供体官能团的吖啶酯，以抑制伪碱的形成，或在吖啶核上具有或不具有电子供体官能团的吖啶磺酰胺。
• High Quantum Yield Acridinium Compounds and Their Uses in Improving Assay Sensitivity
  申请人：Natrajan Anand

  公开号：US20080014660A1

  公开（公告）日：2008-01-17

  The present invention relates to hydrophilic, high quantum yield acridinium compounds. It has been discovered that the placement of electron-donating groups in the acridinium ring system increases the amount of light that is emitted by the corresponding acridinium compound when its chemiluminescence is triggered by alkaline peroxide. More specifically, it has been found that the placement of one or two hydrophilic, alkoxy groups at the C-2 and/or C-7 position of the acridinium ring system of acridinium compounds increases their quantum yield and enhances the aqueous solubility of these compounds. The present hydrophilic, high quantum yield, acridinium compounds are useful chemiluminescent labels for improving the sensitivity of immunoassays.

  本发明涉及亲水性高量子产率的吖啶类化合物。已经发现，在吖啶环系中引入电子供体基团可以增加相应吖啶化合物在碱性过氧化物引发的化学发光时所发射的光量。更具体地，发现在吖啶环系的C-2和/或C-7位置引入一个或两个亲水性的烷氧基团可以增加吖啶类化合物的量子产率并提高这些化合物的水溶性。本发明的亲水性高量子产率的吖啶类化合物是用于提高免疫分析灵敏度的有用化学发光标记。
• HIGH QUANTUM YIELD ACRIDINIUM COMPOUNDS AND THEIR USES IN IMPROVING ASSAY SENSITIVITY
  申请人：Bayer Healthcare LLC

  公开号：EP1946108A2

  公开（公告）日：2008-07-23
• US7309615B2
  申请人：——

  公开号：US7309615B2

  公开（公告）日：2007-12-18