eudeshonokiol A | 126654-55-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: eudeshonokiol A
• 英文别名: eudeshonokiol；2-[4-[[(1R,4aR,7R,8aR)-7-(2-hydroxypropan-2-yl)-1,4a-dimethyl-2,3,4,5,6,7,8,8a-octahydronaphthalen-1-yl]oxy]-3-prop-2-enylphenyl]-4-prop-2-enylphenol
• CAS: 126654-55-5
• 化学式: C₃₃H₄₄O₃
• 分子量: 488.711
• InChiKey: MNZIBUQUXCOKHC-GMWCSNPESA-N

物化性质

• 沸点：
  587.0±50.0 °C(Predicted)
• 密度：
  1.060±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  8.7
• 重原子数：
  36
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  49.7
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  eudeshonokiol A 在 三氟乙酸 作用下， 以 乙醚 、 苯 为溶剂， 反应 46.0h， 生成 2-O-methylhonokiol
  参考文献：
  名称：

  Neurotrophic sesquiterpene-neolignans from magnolia obovata: structure and neurotrophic activity

  摘要：

  Novel sesquiterpene-neolignans, audesobovatols A (1) and B (2) cudesmagnolol (3), eudeshonokiols A (4) and B (5), clovanemagnolol (6), and caryolanemagnolol (7), have been isolated from the bark of Magnolia obovata. Their structures were elucidated to be sesquiterpenes (eudesmol, 4,4,8-trimethyltricyclo [6.3.1.0(2,5)] dodecane-1,9-diol, and clovanediol) combined through ether bond with neolignans such as obovatol, honokiol, and magnolol on the basis of spectral data, degradation, and/or synthesis. Compounds I, 6, and 7 were found to exhibit interesting neurotrophic activity on a neuronal cell culture system derived from fetal rat hemisphere.

  DOI：

  10.1016/s0040-4020(01)89002-5

文献信息

• Natural preservatives and antimicrobial agents, including compositions thereof
  申请人：Unigen, Inc.

  公开号：US10780173B2

  公开（公告）日：2020-09-22

  Compositions are disclosed herein that comprise a mixture of at least one Albizia extract and a Magnolia extract. In some embodiments, the composition comprises a mixture of at least one Albizia extract enriched for one or more macrocyclic alkaloids and at least one Magnolia extract enrich for one or more lignans.

  本文公开的组合物包括至少一种白花蛇舌草提取物和一种厚朴提取物的混合物。在某些实施方案中，组合物包括至少一种富含一种或多种大环生物碱的白花蛇舌草提取物和至少一种富含一种或多种木脂素的厚朴提取物的混合物。
• Fukuyama, Yoshiyasu; Otoshi, Yukio; Nakamura, Kazuhiko, Chemistry Letters, 1990, # 2, p. 295 - 296
  作者：Fukuyama, Yoshiyasu、Otoshi, Yukio、Nakamura, Kazuhiko、Kodama, Mitsuaki、Sugawara, Michiharu、Nagaswa, Masakazu

  DOI：——

  日期：——
• FUKUYAMA, YOSHIYASU;OTOSHI, YUKIO;NAKAMURA, KAZUHIKO;KODAMA, MITSUAKI;SUG+, CHEM. LETT.,(1990) N, C. 295-296
  作者：FUKUYAMA, YOSHIYASU、OTOSHI, YUKIO、NAKAMURA, KAZUHIKO、KODAMA, MITSUAKI、SUG+

  DOI：——

  日期：——
• NATURAL PRESERVATIVES AND ANTIMICROBIAL AGENTS, INCLUDING COMPOSITIONS THEREOF
  申请人：Unigen, Inc.

  公开号：EP3373946A1

  公开（公告）日：2018-09-19
• COMPOSITIONS COMPRISING EXTRACTS OF APLINIA AND OTHER PLANTS FOR IMPROVING JOINT HEALTH AND TREATING ARTHRITIS
  申请人：Unigen, Inc.

  公开号：EP4100034A1

  公开（公告）日：2022-12-14