2,2,4,4-tetramethyl-5-methylenecycloheptanol | 1312299-09-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 2,2,4,4-tetramethyl-5-methylenecycloheptanol
• 英文别名: 2,2,4,4-Tetramethyl-5-methylidenecycloheptan-1-ol
• CAS: 1312299-09-4
• 化学式: C₁₂H₂₂O
• 分子量: 182.306
• InChiKey: ICZIIHGJVJSGMK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2,2,4-trimethyl-5-phenyldimethylsilylmethyl-1,2-epoxy-5-hexene 在 草酰氯 、 三氟化硼乙醚 、 二甲基亚砜 作用下， 以 二氯甲烷 为溶剂， 反应 0.66h， 生成 2,2,4,4-tetramethyl-5-methylenecycloheptanol
  参考文献：
  名称：

  Seven-Membered Ring Formation from Cyclopropanated Oxo- and Epoxyallylsilanes

  摘要：

  A useful strategy for cycloheptane annulations from oxo- and epoxyallylsilanes, prepared by silylcupration of allenes, has been developed, and their application to the stereoselective synthesis of 4-methylenecycloheptan-1-ols is of great potential in the construction of seven-membered ring natural products presented.

  DOI：

  10.1021/jo200705u

文献信息

• Seven-Membered Ring Formation from Cyclopropanated Oxo- and Epoxyallylsilanes
  作者：Francisco J. Pulido、Asunción Barbero、Pilar Castreño

  DOI：10.1021/jo200705u

  日期：2011.7.15

  A useful strategy for cycloheptane annulations from oxo- and epoxyallylsilanes, prepared by silylcupration of allenes, has been developed, and their application to the stereoselective synthesis of 4-methylenecycloheptan-1-ols is of great potential in the construction of seven-membered ring natural products presented.