[5-(3,5-O-(di-tert-butylsilanediyl)-2-O-tert-butyldimethylsilyl-β-D-ribofuranosyl)methyltetrazol-2-yl]methyl 2,2-dimethylpropionate | 1443776-70-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: [5-(3,5-O-(di-tert-butylsilanediyl)-2-O-tert-butyldimethylsilyl-β-D-ribofuranosyl)methyltetrazol-2-yl]methyl 2,2-dimethylpropionate
• 英文别名: [5-[[(4aR,6S,7S,7aR)-2,2-ditert-butyl-7-[tert-butyl(dimethyl)silyl]oxy-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxasilin-6-yl]methyl]tetrazol-2-yl]methyl 2,2-dimethylpropanoate
• CAS: 1443776-70-2
• 化学式: C₂₇H₅₂N₄O₆Si₂
• 分子量: 584.904
• InChiKey: KSURAKOQWIIGKT-YUVXSKOASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.38
• 重原子数：
  39
• 可旋转键数：
  11
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  107
• 氢给体数：
  0
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  [5-(3,5-O-(di-tert-butylsilanediyl)-2-O-tert-butyldimethylsilyl-β-D-ribofuranosyl)methyltetrazol-2-yl]methyl 2,2-dimethylpropionate 在 4-二甲氨基吡啶 、 4,5-二氰基咪唑 、 氟化氢吡啶 、 三乙胺 作用下， 以 吡啶 、 二氯甲烷 为溶剂， 反应 5.5h， 生成 {5-[5-O-(4,4'-dimethoxytrityl)-2-O-tert-butyldimethylsilyl-3-O-(2-cyanoethoxy-N,N-diisopropylaminophosphino)-β-D-ribofuranosyl]methyltetrazol-2-yl}methyl 2,2-dimethylpropionate
  参考文献：
  名称：

  Efficient Transformation of Inactive Nitriles into 5-Substituted 1H-Tetrazoles Using Microwave Irradiation and Their Applications

  摘要：

  Efficient transformations of inactive nitriles into 5-substituted 1H-tetrazoles in DMF in a microwave reactor are described. The present method is applied to the synthesis of tetrazolato-bridged dinuclear platinum(II) complex and tetrazole C-1-ribonucleoside phosphoramidite.

  DOI：

  10.1055/s-0032-1318476
• 作为产物：
  描述：

  [5-(3,5-O-(di-tert-butylsilanediyl)-β-D-ribofuranosyl)methyltetrazol-2-yl]methyl 2,2-dimethylpropionate 、 叔丁基二甲基氯硅烷 在 咪唑 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 3.0h， 以93%的产率得到[5-(3,5-O-(di-tert-butylsilanediyl)-2-O-tert-butyldimethylsilyl-β-D-ribofuranosyl)methyltetrazol-2-yl]methyl 2,2-dimethylpropionate
  参考文献：
  名称：

  Efficient Transformation of Inactive Nitriles into 5-Substituted 1H-Tetrazoles Using Microwave Irradiation and Their Applications

  摘要：

  Efficient transformations of inactive nitriles into 5-substituted 1H-tetrazoles in DMF in a microwave reactor are described. The present method is applied to the synthesis of tetrazolato-bridged dinuclear platinum(II) complex and tetrazole C-1-ribonucleoside phosphoramidite.

  DOI：

  10.1055/s-0032-1318476

文献信息

• Efficient Transformation of Inactive Nitriles into 5-Substituted 1H-Tetrazoles Using Microwave Irradiation and Their Applications
  作者：Shinya Harusawa、Hiroki Yoneyama、Yoshihide Usami、Seiji Komeda

  DOI：10.1055/s-0032-1318476

  日期：——

  Efficient transformations of inactive nitriles into 5-substituted 1H-tetrazoles in DMF in a microwave reactor are described. The present method is applied to the synthesis of tetrazolato-bridged dinuclear platinum(II) complex and tetrazole C-1-ribonucleoside phosphoramidite.