ethyl 6,7-dimethylquinoline-2-carboxylate | 1356126-67-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: ethyl 6,7-dimethylquinoline-2-carboxylate
• 英文别名: Ethyl 6,7-dimethylquinoline-2-carboxylate
• CAS: 1356126-67-4
• 化学式: C₁₄H₁₅NO₂
• 分子量: 229.279
• InChiKey: FLMZCMOFGMIJBJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  39.2
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-碘-4,5-二甲基苯胺 在 哌啶 、 copper(l) iodide 、 trans-bis(triphenylphosphine)palladium dichloride 、 sodium sulfate 、 二乙胺 、 三氟乙酸 、 copper(ll) bromide 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 1.0h， 生成 ethyl 6,7-dimethylquinoline-2-carboxylate
  参考文献：
  名称：

  Copper-Catalyzed [5 + 1] Annulation of 2-Ethynylanilines with an N,O-Acetal Leading to Construction of Quinoline Derivatives

  摘要：

  A novel copper-catalyzed [5 + 1] annulation of 2-ethynylanilines with an N,O-acetal, which functioned as a Cl part, leading to the preparation of quinoline derivatives with an ester substituent on the 2-position is described. A combination of CuBr2 and trifluoroacetic acid (TFA) promoting [5 + 1] annulation of the 2-ethynylaniline with ethyl glyoxylate is also demonstrated.

  DOI：

  10.1021/ol203360g

文献信息

• Copper-Catalyzed [5 + 1] Annulation of 2-Ethynylanilines with an <i>N</i>,<i>O</i>-Acetal Leading to Construction of Quinoline Derivatives
  作者：Norio Sakai、Kosuke Tamura、Kazuyori Shimamura、Reiko Ikeda、Takeo Konakahara

  DOI：10.1021/ol203360g

  日期：2012.2.3

  A novel copper-catalyzed [5 + 1] annulation of 2-ethynylanilines with an N,O-acetal, which functioned as a Cl part, leading to the preparation of quinoline derivatives with an ester substituent on the 2-position is described. A combination of CuBr2 and trifluoroacetic acid (TFA) promoting [5 + 1] annulation of the 2-ethynylaniline with ethyl glyoxylate is also demonstrated.