6-Methoxy-3-methyl-2-oxoquinoline | 123990-77-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 6-Methoxy-3-methyl-2-oxoquinoline
• 英文别名: 3-Methyl-6-methoxyquinolin-2(1H)-one；6-methoxy-3-methyl-1H-quinolin-2-one
• CAS: 123990-77-2
• 化学式: C₁₁H₁₁NO₂
• 分子量: 189.214
• InChiKey: QCBROBWIZQNGBZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  6-Methoxy-3-methyl-2-oxoquinoline 、 碘甲烷 在 potassium carbonate 作用下， 以 二甲基亚砜 为溶剂， 反应 5.0h， 以19%的产率得到2,6-Dimethoxy-3-methyl-quinoline
  参考文献：
  名称：

  Srivastava, Ranjan; Seth, M.; Bhaduri, A. P., Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1989, vol. 28, # 1-11, p. 65 - 66

  摘要：

  DOI：
• 作为产物：
  描述：

  2-氯-6-甲氧基-3-甲基喹啉 在 盐酸 作用下， 以 甲醇 为溶剂， 反应 25.0h， 以10%的产率得到6-Methoxy-3-methyl-2-oxoquinoline
  参考文献：
  名称：

  Srivastava, Ranjan; Seth, M.; Bhaduri, A. P., Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1989, vol. 28, # 1-11, p. 65 - 66

  摘要：

  DOI：

文献信息

• Glutamate transporter activators and methods using same
  申请人：DREXEL UNIVERSITY

  公开号：US11377452B2

  公开（公告）日：2022-07-05

  The present invention provides compounds useful for treating, ameliorating or preventing a disease or disorder that is caused, induced or characterized by abnormal reduction in glutamate transporter activity or abnormal increase in extracellular CNS glutamate concentration in a subject. In certain embodiments, the compound stimulates a glutamate transporter.

  本发明提供的化合物可用于治疗、改善或预防由谷氨酸转运体活性异常降低或细胞外中枢神经系统谷氨酸浓度异常升高引起、诱发或表征的疾病或紊乱。在某些实施方案中，化合物可刺激谷氨酸转运体。
• Metallation of Methoxy-2(1H)-quinolinones
  作者：Carmen Avendaño、Trinidad Moreno、María Fernández、Elena de la Cuesta

  DOI：10.3987/com-95-7366

  日期：——
• SRIVASTAVA, RANJAN P.;SETH, M.;BHADURI, A. P., INDIAN J. CHEM. B , 28,(1989) N, C. 65-66
  作者：SRIVASTAVA, RANJAN P.、SETH, M.、BHADURI, A. P.

  DOI：——

  日期：——
• Glutamate Transporter Activators and Methods Using Same
  申请人：Drexel University

  公开号：US20200255445A1

  公开（公告）日：2020-08-13

  The present invention provides compounds useful for treating, ameliorating or preventing a disease or disorder that is caused, induced or characterized by abnormal reduction in glutamate transporter activity or abnormal increase in extracellular CNS glutamate concentration in a subject. In certain embodiments, the compound stimulates a glutamate transporter.
• NOVEL COMPOUND AND METHOD FOR PREVENTING OR TREATING OF RESPIRATORY DISEASES COMPRISING THE SAME AS AN ACTIVE INGREDIENT
  申请人：YONSEI UNIVERSITY, UNIVERSITY - INDUSTRY FOUNDATION (UIF)

  公开号：US20220193041A1

  公开（公告）日：2022-06-23

  The present invention relates to a novel compound, and a composition for preventing or treating of respiratory disease comprising the novel compound, E- or Z-isomer thereof, optical isomer thereof, a mixture of two isomers thereof, precursor thereof, pharmaceutically acceptable salt thereof or solvate thereof as an active ingredient.