3-(4'-acetylbiphenyl-4-yl)cyclohex-2-enone | 1095476-82-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-(4'-acetylbiphenyl-4-yl)cyclohex-2-enone
• 英文别名: 3-[4-(4-Acetylphenyl)phenyl]cyclohex-2-en-1-one；3-[4-(4-acetylphenyl)phenyl]cyclohex-2-en-1-one
• CAS: 1095476-82-6
• 化学式: C₂₀H₁₈O₂
• 分子量: 290.362
• InChiKey: SEGLRVQLGRACBF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-环己烯-1-酮 、 4-碘苯硼酸 、 4-乙酰基苯硼酸 在 新铜试剂 、 氧气 、 palladium diacetate 、 sodium hydroxide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 22.0h， 以78%的产率得到3-(4'-acetylbiphenyl-4-yl)cyclohex-2-enone
  参考文献：
  名称：

  Chemoselective three-component coupling via a tandem Pd-catalyzed boron-Heck and Suzuki reactions

  摘要：

  A new approach is herein reported to prepare biaryl derivatives via a tandem Pd-catalyzed boron-Heck and Suzuki reactions. This one-pot tandem process avoided purification or addition of extra catalyst between steps. The resulting biaryl compounds can be prepared with substrate variability in good to moderate yields. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.10.039

文献信息

• Chemoselective three-component coupling via a tandem Pd-catalyzed boron-Heck and Suzuki reactions
  作者：Justin O’Neill、Kyung Soo Yoo、Kyung Woon Jung

  DOI：10.1016/j.tetlet.2008.10.039

  日期：2008.12

  A new approach is herein reported to prepare biaryl derivatives via a tandem Pd-catalyzed boron-Heck and Suzuki reactions. This one-pot tandem process avoided purification or addition of extra catalyst between steps. The resulting biaryl compounds can be prepared with substrate variability in good to moderate yields. (C) 2008 Elsevier Ltd. All rights reserved.