tert-Butyl-[(R)-(R)-1-(1,4-dioxa-spiro[4.5]dec-2-yl)-tridecyloxy]-diphenyl-silane | 852203-43-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: tert-Butyl-[(R)-(R)-1-(1,4-dioxa-spiro[4.5]dec-2-yl)-tridecyloxy]-diphenyl-silane
• 英文别名: tert-butyl-[(1R)-1-[(3R)-1,4-dioxaspiro[4.5]decan-3-yl]tridecoxy]-diphenylsilane
• CAS: 852203-43-1
• 化学式: C₃₇H₅₈O₃Si
• 分子量: 578.951
• InChiKey: OFJCVYGAAMHBPS-VSJLXWSYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.32
• 重原子数：
  41
• 可旋转键数：
  17
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  tert-Butyl-[(R)-(R)-1-(1,4-dioxa-spiro[4.5]dec-2-yl)-tridecyloxy]-diphenyl-silane 在 吡啶 、 sodium hydroxide 、 四丁基氟化铵 、 potassium carbonate 、 臭氧 、 三氟乙酸 、 copper(I) bromide 作用下， 以 四氢呋喃 、 甲醇 、 水 为溶剂， 生成 (5R)-5-[(1R)-1-羟基十三烷基]四氢呋喃-2-酮
  参考文献：
  名称：

  (R)-2,3-Cyclohexylideneglyceraldehyde, a novel template for facile and simple entry into chiral hydroxy γ-lactones: synthesis of (−)-muricatacin

  摘要：

  (R)-2,3-Cyclohexylideneglyceraldehyde 1 has been used in a simple and efficient synthesis of (-)-muricatacin 10. The required chiron, syn-alkanetriol 2a was prepared by the reduction of a ketone 3 derived from 1. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2005.03.002
• 作为产物：
  描述：

  (R)-1,4-二氧杂螺[4,5]癸烷-2-甲醛 在 咪唑 作用下， 生成 tert-Butyl-[(R)-(R)-1-(1,4-dioxa-spiro[4.5]dec-2-yl)-tridecyloxy]-diphenyl-silane
  参考文献：
  名称：

  (R)-2,3-Cyclohexylideneglyceraldehyde, a novel template for facile and simple entry into chiral hydroxy γ-lactones: synthesis of (−)-muricatacin

  摘要：

  (R)-2,3-Cyclohexylideneglyceraldehyde 1 has been used in a simple and efficient synthesis of (-)-muricatacin 10. The required chiron, syn-alkanetriol 2a was prepared by the reduction of a ketone 3 derived from 1. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2005.03.002

文献信息

• (R)-2,3-Cyclohexylideneglyceraldehyde, a novel template for facile and simple entry into chiral hydroxy γ-lactones: synthesis of (−)-muricatacin
  作者：Bhaskar Dhotare、Angshuman Chattopadhyay

  DOI：10.1016/j.tetlet.2005.03.002

  日期：2005.4

  (R)-2,3-Cyclohexylideneglyceraldehyde 1 has been used in a simple and efficient synthesis of (-)-muricatacin 10. The required chiron, syn-alkanetriol 2a was prepared by the reduction of a ketone 3 derived from 1. (c) 2005 Elsevier Ltd. All rights reserved.