N1,N1,N4,N4-四甲基苯-1,4-二胺氯化物盐 | 637-01-4

• 物质功能分类: 有机原料 - 氨基化合物 - 无环单胺、多胺及其衍生物和盐
• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: N1,N1,N4,N4-四甲基苯-1,4-二胺氯化物盐
• 中文别名: 2,6-脱水-1-脱氧庚-1-烯糖醇
• 英文名称: 1-N,1-N,4-N,4-N-tetramethylbenzene-1,4-diamine;chloride
• CAS: 637-01-4；13327-28-1；74563-77-2
• 化学式: C₁₀H₁₆N₂*Cl
• 分子量: 199.703
• InChiKey: DNRUPOAHVJBDJE-UHFFFAOYSA-M

物化性质

• 熔点：
  222-224 °C(lit.)
• 沸点：
  378.54°C (rough estimate)
• 密度：
  1.1961 (rough estimate)
• 溶解度：
  H2O中可溶500mg/10 mL

计算性质

• 辛醇/水分配系数(LogP)：
  -1.18
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  6.5
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• TSCA：
  Yes
• 危险等级：
  6.1(a)
• 危险品标志：
  Xn
• 安全说明：
  S26,S36,S36/37
• 危险类别码：
  R20/21/22
• WGK Germany：
  3
• 海关编码：
  29215190
• 包装等级：
  II
• 危险类别：
  6.1(a)
• 危险品运输编号：
  2811
• 危险性防范说明：
  P261,P264,P270,P271,P280,P301+P312+P330,P302+P352+P312+P362+P364,P304+P340+P312,P305+P351+P338+P337+P313,P501
• 危险性描述：
  H302+H312+H332,H315,H319

制备方法与用途

概述

N,N,N',N'-四甲基对苯二胺二盐酸盐又叫盐酸四甲基对苯二胺，简称TMPD，是一种氧化酶试剂，可用于鉴别淋球菌。

应用

该化合物可以用于鉴别淋球菌。其原理是淋球菌具有氧化酶，能将N,N,N',N'-四甲基对苯二胺二盐酸盐氧化成醌类化合物，从而出现颜色反应。

生物活性

TMPD dihydrochloride 是一种易于氧化的化合物，作为酶促转化的氧化还原活性底物分子。它也是一种电子供体，并可作为血红素过氧化物酶的还原共底物。此外，TMPD dihydrochloride 也可以作为 complex IV 的底物。

体外研究

TMPD（N,N,N′,N′-四甲基-对-苯二胺）在细胞培养和微生物学中用于区分具有细胞色素c氧化酶活性的菌株，并能区别革兰氏阴性和阳性致病及非致病细菌。微生物对 TMPD 的氧化概念被广泛使用，作为一种成功的颜色指示剂来检测细菌的氧化酶，因为由氧化产生的 TMPD+˙ 离子会显示出特有的深蓝色。通过电化学识别细菌氧化酶对 TMPD 的氧化作用可以应用于多种病原菌的研究。

反应信息

• 作为产物：
  描述：

  N,N,N',N'-四甲基对苯二胺 在 四氯化碳 作用下， 生成 N1,N1,N4,N4-四甲基苯-1,4-二胺氯化物盐
  参考文献：
  名称：

  Contact ion pairs formed from photolyzed TMPD-carbon tetrachloride and TMPD-carbon tetrachloride-benzene solutions studied by the time-resolved microwave dielectric absorption technique

  摘要：

  One-photon ionization of TMPD has been investigated by observing the time variation of microwave dielectric loss caused by irradiation of 355-nm laser pulses on a solution of TMPD in CCl4 and on that containing both TMPD and CCl4 in C6H6 solvent. In the TMPD-CCl4 system the observed signal shows a rapid growth followed by a second-order decay along with much slower decays. These features can be interpreted as reflecting the formation of contact ion pairs (TMPD+Cl-) and their mutual association leading to ion-pair dimers and clusters. In the TMPD-CCl4-C6H6 system a first-order growth of the dielectric absorption is observed, which corresponds to ion-pair formation by electron transfer from the excited triplet state of TMPD to CCl4, and the reaction rate is diffusion-controlled. The dipole moment of the ion pair has been estimated to be 11 +/- 3 D from two different methods; one based on the amplitude of the detected signal and the other on the rate constant for the ion-pair association. The dipole moment of the ion-pair dimer appears to be larger than that of the ion pair itself. The analysis of data leads to a suggestion that the quantum yield of the ion-pair formation is close to unity.

  DOI：

  10.1021/j100169a032

文献信息

• Contact ion pairs formed from photolyzed TMPD-carbon tetrachloride and TMPD-carbon tetrachloride-benzene solutions studied by the time-resolved microwave dielectric absorption technique
  作者：Hiroshi Shimamori、Hisakazu Uegaito

  DOI：10.1021/j100169a032

  日期：1991.8

  One-photon ionization of TMPD has been investigated by observing the time variation of microwave dielectric loss caused by irradiation of 355-nm laser pulses on a solution of TMPD in CCl4 and on that containing both TMPD and CCl4 in C6H6 solvent. In the TMPD-CCl4 system the observed signal shows a rapid growth followed by a second-order decay along with much slower decays. These features can be interpreted as reflecting the formation of contact ion pairs (TMPD+Cl-) and their mutual association leading to ion-pair dimers and clusters. In the TMPD-CCl4-C6H6 system a first-order growth of the dielectric absorption is observed, which corresponds to ion-pair formation by electron transfer from the excited triplet state of TMPD to CCl4, and the reaction rate is diffusion-controlled. The dipole moment of the ion pair has been estimated to be 11 +/- 3 D from two different methods; one based on the amplitude of the detected signal and the other on the rate constant for the ion-pair association. The dipole moment of the ion-pair dimer appears to be larger than that of the ion pair itself. The analysis of data leads to a suggestion that the quantum yield of the ion-pair formation is close to unity.