2-(3-hydroxy-3,7,11,15-tetramethylhexadecyl)-3-methylnaphthalene-1,4-dione | 7293-25-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 2-(3-hydroxy-3,7,11,15-tetramethylhexadecyl)-3-methylnaphthalene-1,4-dione
• 英文别名: 2-Methyl-3-(3-hydroxy-2,3-dihydro-phytyl)-1,4-naphthochinon；3-(3-hydroxy-3,7,11,15-tetramethylhexadecyl)-2-methyl-1,4-naphthochinon；3-(3-Hydroxy-3,7,11,15-tetramethyl-hexadecyl)-2-methyl-naphthochinon-(1,4)；2-Methyl-3-<3-hydroxy-2.3-dihydro-phytyl>-1.4-naphthochinon
• CAS: 7293-25-6
• 化学式: C₃₁H₄₈O₃
• 分子量: 468.72
• InChiKey: ZYZWUEIPVNFQQC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.4
• 重原子数：
  34
• 可旋转键数：
  15
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 甲醇 、 水 、 三氯化铁 作用下， 生成 2-(3-hydroxy-3,7,11,15-tetramethylhexadecyl)-3-methylnaphthalene-1,4-dione
  参考文献：
  名称：

  Nature of the By-product in the Synthesis of Vitamin K₁

  摘要：

  DOI：

  10.1021/ja01865a022

文献信息

• Additional Observations on the Vitamin K Activity of Quinones
  作者：Erhard Fernholz、H. B. MacPhillamy、S. Ansbacher

  DOI：10.1021/ja01863a503

  日期：1940.6
• [EN] THERAPEUTIC COMPOSITIONS INCLUDING NAPHTHOQUINONES AND USES THEREOF<br/>[FR] COMPOSITIONS THÉRAPEUTIQUES COMPRENANT DES NAPHTHOQUINONES ET LEURS UTILISATIONS
  申请人：STEALTH PEPTIDES INT INC

  公开号：WO2015183985A2

  公开（公告）日：2015-12-03

  Disclosed herein are methods and compositions for the treatment and/or prevention of diseases or conditions comprising administration of naphthoquinones, and/or naturally or artificially occurring derivatives, analogues, or pharmaceutically acceptable salts thereof, alone or in combination with one or more active agents (e.g., an aromatic-cationic peptide). The present technology provides compositions related to aromatic-cationic peptides linked to naphthoquinones and uses of the same. In some embodiments, the aromatic-cationic peptide comprises 2',6'-dimethyl-Tyr-D-Arg-Phe-Lys-NH2, Phe-D-Arg-Phe-Lys-NH2, or D-Arg-2',6'-Dmt-Lys-Phe-NH2.
• Nature of the By-product in the Synthesis of Vitamin K₁
  作者：Max Tishler、Louis F. Fieser、Norman L. Wendler

  DOI：10.1021/ja01865a022

  日期：1940.8