2,4-Dicyclohexyl-quinolin-8-ylamine | 716328-59-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2,4-Dicyclohexyl-quinolin-8-ylamine
• 英文别名: 2,4-Dicyclohexylquinolin-8-amine
• CAS: 716328-59-5
• 化学式: C₂₁H₂₈N₂
• 分子量: 308.467
• InChiKey: NQAJSNIUIQUFIU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  38.9
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  三氟乙酸酐 、 2,4-Dicyclohexyl-quinolin-8-ylamine 反应 4.0h， 以97%的产率得到N-(2,4-Dicyclohexyl-quinolin-8-yl)-2,2,2-trifluoro-acetamide
  参考文献：
  名称：

  Ring-substituted quinolines as potential anti-tuberculosis agents

  摘要：

  We report in vitro antimycobacterial properties of ring-substituted quinolines (series 1-4) constituting 56 analogues against drug-sensitive and drug-resistant If. tuberculosis H37Rv strains. The most effective compounds 2h (R-1 = R-2 = c-C6H11, R-3 = NO2, series 1) and 13g (R-1 = OC7H15, R-2 = NO2, series 4) have exhibited an MIC value of 1 mug/mL against drug-sensitive If. tuberculosis H37Rv strain that is comparable to first lisle anti-tuberculosis drug, isoniazid. :Selected analogues (2d, 2g 2h, 4e, 6b, 13b, 13g, and 14e, MIC: less than or equal to6.25 mug/mL) upon further evaluation against single-drug-resistant (SDR) strains of M. tuberculosis H37Rv 9 have produced potent efficacy in the range between 6.25 and 50 mug/mL. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2004.03.045
• 作为产物：
  描述：

  8-硝基喹啉 在 镍 ammonium persulfate 、 硫酸 、 氢气 、 silver nitrate 作用下， 以 乙醇 、 水 、 乙腈 为溶剂， 20.0~80.0 ℃ 、310.26 kPa 条件下， 反应 1.17h， 生成 2,4-Dicyclohexyl-quinolin-8-ylamine
  参考文献：
  名称：

  Ring-substituted quinolines as potential anti-tuberculosis agents

  摘要：

  We report in vitro antimycobacterial properties of ring-substituted quinolines (series 1-4) constituting 56 analogues against drug-sensitive and drug-resistant If. tuberculosis H37Rv strains. The most effective compounds 2h (R-1 = R-2 = c-C6H11, R-3 = NO2, series 1) and 13g (R-1 = OC7H15, R-2 = NO2, series 4) have exhibited an MIC value of 1 mug/mL against drug-sensitive If. tuberculosis H37Rv strain that is comparable to first lisle anti-tuberculosis drug, isoniazid. :Selected analogues (2d, 2g 2h, 4e, 6b, 13b, 13g, and 14e, MIC: less than or equal to6.25 mug/mL) upon further evaluation against single-drug-resistant (SDR) strains of M. tuberculosis H37Rv 9 have produced potent efficacy in the range between 6.25 and 50 mug/mL. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2004.03.045

文献信息

• Ring-substituted quinolines as potential anti-tuberculosis agents
  作者：Suryanarayana Vangapandu、Meenakshi Jain、Rahul Jain、Sukhraj Kaur、Prati Pal Singh

  DOI：10.1016/j.bmc.2004.03.045

  日期：2004.5

  We report in vitro antimycobacterial properties of ring-substituted quinolines (series 1-4) constituting 56 analogues against drug-sensitive and drug-resistant If. tuberculosis H37Rv strains. The most effective compounds 2h (R-1 = R-2 = c-C6H11, R-3 = NO2, series 1) and 13g (R-1 = OC7H15, R-2 = NO2, series 4) have exhibited an MIC value of 1 mug/mL against drug-sensitive If. tuberculosis H37Rv strain that is comparable to first lisle anti-tuberculosis drug, isoniazid. :Selected analogues (2d, 2g 2h, 4e, 6b, 13b, 13g, and 14e, MIC: less than or equal to6.25 mug/mL) upon further evaluation against single-drug-resistant (SDR) strains of M. tuberculosis H37Rv 9 have produced potent efficacy in the range between 6.25 and 50 mug/mL. (C) 2004 Elsevier Ltd. All rights reserved.