6-Fluoro-8-nitro-2,3-dihydro-1H-quinolin-4-one | 134602-15-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 6-Fluoro-8-nitro-2,3-dihydro-1H-quinolin-4-one
• 英文别名: 6-fluoro-8-nitro-2,3-dihydroquinolin-4(1H)-one；6-fluoro-2,3-dihydro-8-nitro-4(1H)-quinolinone
• CAS: 134602-15-6
• 化学式: C₉H₇FN₂O₃
• 分子量: 210.165
• InChiKey: JMPAYHIRAHCOKM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  74.9
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  6-Fluoro-8-nitro-2,3-dihydro-1H-quinolin-4-one 在 palladium 10% on activated carbon 氢气 、 溶剂黄146 作用下， 以 乙酸乙酯 为溶剂， 反应 18.0h， 生成 8-amino-6-fluoro-2,3-dihydro-1H-quinolin-4-one
  参考文献：
  名称：

  Tricyclic benzimidazoles and their use as metabotropic glutamate receptor modulators

  摘要：

  该发明提供了一个式(I)的化合物或其药用盐：其中R1、R2、R3、A、B、D、m、n、x和y的定义如规范中所述。该发明还提供了一种包含式I化合物的药用组合物，以及使用该组合物来治疗或预防神经学和精神疾病的方法。这些化合物在与mGluR2受体介导的疾病的治疗或预防相关的治疗中是有用的。

  公开号：

  US20070032469A1
• 作为产物：
  描述：

  N-(4-fluoro-2-nitrophenyl)-β-alanine 在 Eaton's reagent 作用下， 反应 3.5h， 以57%的产率得到6-Fluoro-8-nitro-2,3-dihydro-1H-quinolin-4-one
  参考文献：
  名称：

  Tricyclic benzimidazoles and their use as metabotropic glutamate receptor modulators

  摘要：

  该发明提供了一个式(I)的化合物或其药用盐：其中R1、R2、R3、A、B、D、m、n、x和y的定义如规范中所述。该发明还提供了一种包含式I化合物的药用组合物，以及使用该组合物来治疗或预防神经学和精神疾病的方法。这些化合物在与mGluR2受体介导的疾病的治疗或预防相关的治疗中是有用的。

  公开号：

  US20070032469A1

文献信息

• [EN] 4,5-DIHYDRO-IMIDAZO[4,5,1-II]QUINOLIN-6-ONES AS PARP INHIBITORS<br/>[FR] 4,5-DIHYDRO-IMIDAZO(4,5,1-IJ)QUINOLIN-6-ONES UTILISEES COMME INHIBITEURS DE PARP
  申请人：ALTANA PHARMA AG

  公开号：WO2004108723A1

  公开（公告）日：2004-12-16

  Compounds of the formula 1, in which R1 and R2 have the meanings indicated in the description, are novel active PARP inhibitors.

  式1中，其中R1和R2具有描述中指示的含义的化合物是新颖的活性PARP抑制剂。
• 4,5-dihydro-6H-imidazo[4,5,1-ij]quinolin-6-one-6-oxime-O-sulfonic acid
  申请人：Mochida Pharmaceutical Co., Ltd.

  公开号：US05151431A1

  公开（公告）日：1992-09-29

  The present invention relates to novel 4,5-dihydro-6H-imidazo[4,5,1-ij]quinolin-6-one-6-oxime-O-sulfonic acid compounds, processes for producing said compounds, intermediate compounds, i.e. novel 4,5-dihydro-6H-imidazo[4,5,1-ij]quinolin-6-one compounds and 4,5-dihydro-6H-imidazo[4,5,1-ij]quinolin-6-one-6-oxime compounds in the synthesis of said compounds, processes for producing said intermediate compounds, and pharmaceutical or veterinary compositions containing said compounds. The present invention is based on the selection of the substituents of 4,5-dihydro-6H-imidazo[4,5,1-ij]-quinolin-6-one-6-oxime-O-sulfonic acid compounds at 2-position, namely 2-(2-penten-3-yl)-, 2-cyclohexyl-, 2-naphthyl-, 2-thienyl-, etc. The compounds of the present invention containing these substituents have potent hypotensive, anti-oedematous and diuretic effects as well as an activity of removing ascites. The compounds of the present invention are extremely useful for treatment of diseases and disorders mentioned above.

  本发明涉及新的4,5-二氢-6H-咪唑并[4,5,1-ij]喹啉-6-酮-6-肟-O-磺酸化合物，制备该化合物的方法，中间体化合物，即新的4,5-二氢-6H-咪唑并[4,5,1-ij]喹啉-6-酮化合物和4,5-二氢-6H-咪唑并[4,5,1-ij]喹啉-6-酮-6-肟化合物在该化合物的合成中的应用，制备该中间体化合物的方法，以及含有该化合物的药物或兽医组合物。本发明基于在2位处选择4,5-二氢-6H-咪唑并[4,5,1-ij]-喹啉-6-酮-6-肟-O-磺酸化合物的取代基，即2-(2-戊烯-3-基)-、2-环己基-、2-萘基-、2-噻吩基-等。本发明的含有这些取代基的化合物具有强效的降压、抗水肿和利尿作用，以及除去腹水的活性。本发明的化合物对于上述疾病和障碍的治疗非常有用。
• Tricyclic Benzimidazoles and Their Use as Metabotropic Glutamate Receptor Modulators
  申请人：Isaac Methvin

  公开号：US20080318999A1

  公开（公告）日：2008-12-25

  The invention provides for a compound of formula (I) or a pharmaceutically acceptable salt thereof: wherein R 1 , R 2 , R 3 , A, B, D, m, n, x, and y are defined as described in the specification. The invention additionally provides a pharmaceutically composition comprising the compound of formula I, together with a method of using the same to treat or prevent neurological and psychiatric disorders. The compounds are useful in therapy related to the treatment or prevention of mGluR2 receptor-mediated disorders.

  该发明提供了式（I）的化合物或其药学上可接受的盐：其中，R1、R2、R3、A、B、D、m、n、x和y的定义如规范所述。此外，该发明还提供了包括式I的药学组合物，以及使用该组合物治疗或预防神经系统和精神疾病的方法。这些化合物在治疗或预防mGluR2受体介导的疾病的相关治疗中是有用的。
• 4,5-Dihydro-6H-imidazo[4,5,1-ij]quinolin-6-one-6-oxime-O-sulfonic acid derivatives
  申请人：MOCHIDA PHARMACEUTICAL CO., LTD.

  公开号：EP0405442A1

  公开（公告）日：1991-01-02

  The present invention relates to novel 4,5-dihydro-6H-imidazo[4,5,1-ij]quinolin-6-one-6-oxime-0-sulfonic acid compounds, processes for producing said compounds, intermediate compounds, i.e. novel 4,5-dihydro-6H-imidazo[4,5,1-ij]quinolin-6-one compounds and 4,5-dihydro-6H-imidazo[4,5,1-ij]quinolin-6-one-6-oxime compounds in the synthesis of said compounds, processes for producing said intermediate compounds, and pharmaceutical or veterinary compositions containing said compounds. The present invention is based on the selection of the substituents of 4,5-dihydro-6H-imidazo[4,5,1-ij]-quinolin-6-one-6-oxime-O-sulfonic acid compounds at 2-position, namely 2-(2-penten-3-yl)-, 2-cyclohexyl-, 2-naphthyl-, 2-thienyl-, etc. The compounds of the present invention containing these substituents have potent- hypotensive, antioedematous and diuretic effects as well as an activity of removing ascites. The compounds of the present invention are extremely useful for treatment of diseases and disorders mentioned above.

  本发明涉及新型 4,5-二氢-6H-咪唑并[4,5,1-ij]喹啉-6-酮-6-肟-0-磺酸化合物、生产上述化合物的工艺、中间化合物，即新型 4,5-二氢-6H-咪唑并[4,5,1-ij]喹啉-6-酮化合物和合成所述化合物的 4,5-二氢-6H-咪唑并[4,5,1-ij]喹啉-6-酮-6-肟化合物，生产所述中间化合物的工艺，以及含有所述化合物的药物或兽药组合物。 本发明基于对 4,5-二氢-6H-咪唑并[4,5,1-ij]-喹啉-6-酮-6-肟-O-磺酸化合物 2-位取代基的选择，即 2-(2-戊烯-3-基)-、2-环己基-、2-萘基-、2-噻吩基-等。 含有这些取代基的本发明化合物具有强效降血压、消肿和利尿作用，并具有去除腹水的活性。本发明的化合物对治疗上述疾病和失调非常有用。
• TRICYCLIC INHIBITORS OF POLY(ADP-RIBOSE) POLYMERASES
  申请人：AGOURON PHARMACEUTICALS, INC.

  公开号：EP1208104A2

  公开（公告）日：2002-05-29