蒜氨酸 | 17795-27-6

• 物质功能分类: 生物化工 - 常见氨基酸及蛋白质类
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 蒜氨酸
• 中文别名: 蒜碱
• 英文名称: alliin
• 英文别名: 2-Azaniumyl-3-prop-2-enylsulfinylpropanoate
• CAS: 17795-27-6
• 化学式: C₆H₁₁NO₃S
• mdl: MFCD09842033
• 分子量: 177.224
• InChiKey: XUHLIQGRKRUKPH-UHFFFAOYSA-N

物化性质

• 熔点：
  184-186 °C (decomp)(Solv: acetone (67-64-1))
• 沸点：
  416.1±45.0 °C(Predicted)
• 密度：
  1.354±0.06 g/cm3(Predicted)
• 物理描述：
  Solid

计算性质

• 辛醇/水分配系数(LogP)：
  -3.5
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  99.6
• 氢给体数：
  2
• 氢受体数：
  5

安全信息

• 海关编码：
  2930909090

反应信息

• 作为反应物：
  描述：

  蒜氨酸 在 water extract of garlic 作用下， 以 水 为溶剂， 以99%的产率得到大蒜素
  参考文献：
  名称：

  A Tissue Homogenate Method To Prepare Gram-Scale Allium Thiosulfinates and Their Disulfide Conjugates with Cysteine and Glutathione

  摘要：

  The health benefits of Allium vegetables are widely attributed to the enzyme-derived organosulfur compounds called thiosulfinates (TS). However, the lack of a suitable method to prepare TS in good yields has hampered the evaluation of their biological activities. This paper describe a simple enzymatic method using Allium tissue homogenates as a reaction system to prepare gram-scale TS, including those enriched in 1-propenyl groups, which are particularly difficult to obtain. This method is simple, easy to scale up, and requires no column purification step, making it suitable for practical large-scale production of Allium TS. The prepared TS were further utilized to prepare the disulfide conjugates with cysteine and glutathione (CySSR and GSSR, R = methyl, ethyl, propyl, 1-propenyl, and allyl), which are the presumptive metabolites of TS. Among all of the Allium CySSR and GSSR conjugates, the newly prepared glutathione conjugate with 1-propenyl TS, GSSPe, showed the most potent effect to induce quinone reductase (QR, a representative phase II enzyme) in murine hepatoma cells (Hepa 1c1c7) and inhibit nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated macrophage cells (RAW 264.7).

  DOI：

  10.1021/jf4003818
• 作为产物：
  描述：

  DL-S-烯丙基半胱氨酸 在 双氧水 作用下， 反应 0.05h， 以66.5%的产率得到蒜氨酸
  参考文献：
  名称：

  一种蒜氨酸的制备方法

  摘要：

  本发明公开了一种蒜氨酸的制备方法。该制备方法包括以下步骤：在微反应器中，将如式2所示的脱氧蒜氨酸和氧化剂在溶剂中进行氧化反应，得到如式1所示的蒜氨酸，所述氧化剂与所述如式2所示的脱氧蒜氨酸的摩尔比值为0.9～1.2。本发明所述蒜氨酸的制备方法中原料转化率高，最终产品纯度高，比旋度高，反应时间短，副反应少，且操作简单，后处理简单，具有较好的应用市场。

  公开号：

  CN111285788B

文献信息

• 1H-pyrrole-2,4-dicarbonyl-derivatives and their use as flavoring agents
  申请人：IMAX Discovery GmbH

  公开号：EP2832233A1

  公开（公告）日：2015-02-04

  The present invention primarily relates to 1H-pyrrole-2,4-dicarbonyl-derivatives of Formula (I) wherein R1, R2, R3, Z. Z' and J are as defined in the description, to mixtures thereof and to the use thereof as flavoring agents. The compounds in accordance with the present invention are suitable for producing, imparting, or intensifying an umami flavor. The invention further relates to flavoring mixtures, compositions for oral consumption as well as ready-to-eat, ready-to-use and semifinished products, comprising an effective amount of the compound of Formula (I) or of a mixture of compounds of Formula (I) and to specific methods for producing, imparting, modifying and/or intensifying specific flavor impressions.

  本发明主要涉及式(I)的1H-吡咯-2,4-二羰基衍生物，其中R1、R2、R3、Z、Z'和J按描述定义，及其混合物，以及用作调味剂的使用。根据本发明的化合物适用于生产、赋予或增强鲜味。本发明进一步涉及包含式(I)化合物或式(I)化合物混合物的有效量的调味混合物、口腔消费的组成物以及即食、即用和半成品，以及用于生产、赋予、改变和/或增强特定风味印象的特定方法。
• Imidazo[1,2-a]pyridine-ylmethyl-derivatives and their use as flavoring agents
  申请人：IMAX Discovery GmbH

  公开号：EP2832234A1

  公开（公告）日：2015-02-04

  The present invention primarily relates to imidazo[1,2-a]pyridine-ylmethyl-derivatives of Formula (I) wherein R1, R2, X, W e J are as defined in the description, to mixtures thereof and to the use thereof as flavoring agents. The compounds in accordance with the present invention are suitable for producing, imparting, or intensifying an umami flavor. The invention further relates to flavoring mixtures, compositions for oral consumption as well as ready-to-eat, ready-to-use and semifinished products, comprising an effective amount of the compound of Formula (I) and to specific methods for producing, imparting, modifying and/or intensifying specific flavor impressions.

  本发明主要涉及式(I)的咪唑[1,2-a]吡啶基甲基衍生物，其中R1、R2、X、W和J如描述中定义，以及涉及它们的混合物和使用它们作为调味剂。根据本发明的化合物适合于产生、赋予或增强鲜味。本发明进一步涉及调味混合物、口腔摄入的配方以及包含有效量的式(I)化合物的即食、即用和半成品，以及用于生产、赋予、改变和/或增强特定风味印象的特定方法。
• LIGHT INDUCED DRUG RELEASE
  申请人：Bonnet Sylvestre

  公开号：US20140148425A1

  公开（公告）日：2014-05-29

  Photosensitive compounds for use in a method of treating a disease or condition are described. The photosensitive compounds have the formula R—Y, wherein R is a ruthenium complex and Y is at least one sulphur-containing photoreleasable group, and the compounds comprise at least one ruthenium-sulphur bond; or a pharmaceutically acceptable salt, solvate, ester or amide, such that upon influence of visible or near infra-red light (400-1400 nm) in vivo, said at least one ruthenium-sulphur bond is broken, thereby generating a pharmacologically active compound.

  描述了用于治疗疾病或症状的一种方法中使用的光敏化合物。这些光敏化合物具有R—Y的化学式，其中R是一个钌配合物，Y是至少一个含硫光释放基团，这些化合物包括至少一个钌-硫键；或者是药用可接受的盐、溶剂合物、酯或酰胺，因此，在体内受到可见光或近红外光（400-1400纳米）的影响时，所述至少一个钌-硫键被断裂，从而产生一种药理活性化合物。
• Methods and compositions for malaria prophylaxis
  申请人：Sinnis Photini

  公开号：US20060122266A1

  公开（公告）日：2006-06-08

  A composition for preventing malaria infection including a protease inhibitor. A pharmaceutical composition for preventing malaria infection including a protease inhibitor and a pharmaceutical carrier. A method of malaria infection prophylaxis including the step of administering an effective amount of the composition of the present invention. A method of malaria prophylaxis by inhibiting circumsporozoite protein processing or by inhibiting a protease of a sporozoite. Methods of preventing sporozoite cell invasion or preventing circumsporozoite processing.

  一种预防疟疾感染的组合物，包括蛋白酶抑制剂。一种预防疟疾感染的药物组合物，包括蛋白酶抑制剂和药用载体。一种疟疾感染预防方法，包括向患者施用本发明的组合物的有效量。通过抑制环孢子虫蛋白加工或抑制裂殖体的蛋白酶来预防疟疾的方法。预防裂殖体细胞入侵或预防环孢子虫加工的方法。
• [EN] DIALLYLDISULPHIDE COMPOUNDS HAVING ANTILIPIDEMIC AND ANTIOXIDANT ACTIVITY<br/>[FR] COMPOSES DE DIALLYLDISULFURE PRESENTANT UNE ACTIVITE ANTILIPIDEMIQUE ET ANTIOXYDANTE
  申请人：DEPT OF SCIENCE AND TECHNOLOGY

  公开号：WO2004039771A1

  公开（公告）日：2004-05-13

  The present invention relates to a novel diallyldisulphide derivative having formula I as shown herebelow and their pharmaceutically acceptable salts; R-CH = CH - CH2-S-S-CH2-CH = CH-R (Formula I)wherein R=C6HnXp[when n = 3 to 5, p = 2 to 0; X=H, Cl, Br, F, CF3, CH3, CN, COOH, NO2, NH2, OH, OCmH2m+1(m = 1 to 8)]

  本发明涉及一种新型二烯丙基二硫化物衍生物，其具有下文所示的化学式I及其药学上可接受的盐；R-CH = CH - CH2-S-S- -CH = CH-R（化学式I）其中R=C6HnXp[当n = 3至5，p = 2至0；X=H，Cl，Br，F，CF3，CH3，CN，COOH，NO2，NH2，OH，OCmH2m+1（m = 1至8）]