Lanost-8-en-3-one, 2-(4-carboxy-3-hydroxy-3-methyl-1-oxobutoxy)-24,25-dihydroxy-, (2alpha)- | 184962-60-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: Lanost-8-en-3-one, 2-(4-carboxy-3-hydroxy-3-methyl-1-oxobutoxy)-24,25-dihydroxy-, (2alpha)-
• 英文别名: 5-[[(2R,10S,13R,14R,17R)-17-[(2R)-5,6-dihydroxy-6-methylheptan-2-yl]-4,4,10,13,14-pentamethyl-3-oxo-1,2,5,6,7,11,12,15,16,17-decahydrocyclopenta[a]phenanthren-2-yl]oxy]-3-hydroxy-3-methyl-5-oxopentanoic acid
• CAS: 184962-60-5
• 化学式: C₃₆H₅₈O₈
• 分子量: 618.8
• InChiKey: FNHDSKHVYPYDAZ-JTKQVMFNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  44
• 可旋转键数：
  11
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  141
• 氢给体数：
  4
• 氢受体数：
  8

文献信息

• US5703067A
  申请人：——

  公开号：US5703067A

  公开（公告）日：1997-12-30
• [EN] TERPENOID INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE<br/>[FR] INHIBITEURS A STRUCTURE TERPENOIDALE DE LA FARNESYL-PROTEINE TRANSFERASE
  申请人：MERCK & CO., INC.

  公开号：WO1996035707A1

  公开（公告）日：1996-11-14

  (EN) The present invention is directed to steroidal or terpenoidal compounds which inhibit farnesyl-protein transferase (FPTase). The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and treatment of cancer.(FR) La présente invention se rapporte à des composés stéroïdiens ou terpénoïdaux qui inhibent la farnésyl-protéine transférase (FPTase), ainsi qu'à des compositions chimiothérapeutiques contenant les composés de cette invention, et à des procédés d'inhibition de la farnésyl-protéine transférase et de traitement du cancer.
• [EN] MAMMALIAN GENES INVOLVED IN INFECTION<br/>[FR] GÈNES DE MAMMIFÈRE IMPLIQUÉS DANS L'INFECTION
  申请人：ZIRUS INC

  公开号：WO2010134939A2

  公开（公告）日：2010-11-25

  The present invention relates to nucleic acid sequences and cellular proteins encoded by these sequences that are involved in infection or are otherwise associated with the life cycle of one or more pathogens.