3-Bromo-4-(6-(2-bromo-4-carbamimidoylphenoxy)hexoxy)benzenecarboximidamide | 93856-82-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 3-Bromo-4-(6-(2-bromo-4-carbamimidoylphenoxy)hexoxy)benzenecarboximidamide
• 英文别名: 3-bromo-4-[6-(2-bromo-4-carbamimidoylphenoxy)hexoxy]benzenecarboximidamide
• CAS: 93856-82-7
• 化学式: C₂₀H₂₄Br₂N₄O₂
• 分子量: 512.2
• InChiKey: ZSMKZRXHCAOERY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  28
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  118
• 氢给体数：
  4
• 氢受体数：
  4

文献信息

• COMPOUNDS FOR PREVENTING, REDUCING AND/OR ALLEVIATING ITCHY SKIN CONDITION(S)
  申请人：SCHMAUS Gerhard

  公开号：US20160008297A1

  公开（公告）日：2016-01-14

  The present invention primarily relates to the use of one or more specific compounds and/or one or more respective salt(s) thereof for preventing, reducing or alleviating itchy skin condition(s), and/or as PAR-2 antagonist. Furthermore, the present invention relates to compositions (products or, respectively, formulations), in particular for topical administration, preferably cosmetic or pharmaceutical compositions, in particular for preventing, reducing or alleviating one or more itchy skin conditions and/or for providing a PAR-2 antagonistic effect, comprising or consisting of an effect amount of such compound(s) and/or salt(s) and one or more cosmetically and/or pharmaceutically acceptable carriers.

  本发明主要涉及使用一种或多种特定化合物和/或其一个或多个相应盐来预防、减少或缓解瘙痒皮肤状况，和/或作为PAR-2拮抗剂。此外，本发明涉及组合物（产品或相应的配方），特别是用于局部给药，优选为化妆品或药用组合物，特别是用于预防、减少或缓解一种或多种瘙痒皮肤状况和/或产生PAR-2拮抗作用的组合物，包括或由效果量的这种化合物和/或盐以及一个或多个化妆品和/或药用可接受载体组成。
• Silver dihydrogen citrate compositions
  申请人：Arata B. Andrew

  公开号：US20060051430A1

  公开（公告）日：2006-03-09

  Personal care and home care compositions are disclosed, which include silver dihydrogen citrate. The inventive compositions advantageously take the form of suspensions, pastes, liquids and gels. The inventive compositions also optionally comprise additional ingredients, and are therefore suitable for a wide variety of personal, home and industrial care purposes.

  护理和家居用品组合物被披露，其中包括柠檬酸二氢银。这种创新的组合物有利地采用悬浮液、糊状物、液体和凝胶的形式。这些创新的组合物还可以选择性地包含额外的成分，因此适用于各种个人、家庭和工业护理用途。
• Use of phenylethylamine derivatives for the antimicrobial treatment of surfaces
  申请人：——

  公开号：US20030207884A1

  公开（公告）日：2003-11-06

  The use of compounds of formula (1) is described, in which compounds R 1 , R 2 and R 3 are each independently of the others hydrogen; C 1 -C 20 alkyl; C 3 -C 7 cycloalkyl; C 2 -C 20 alkenyl; C 4 -C 7 cycloalkenyl; C 2 -C 20 alkynyl, C 4 -C 7 cycloalkynyl; or unsubstituted or C 1 -C 5 alkyl-, C 3 -C 7 cylcoalkyl-, C 1 -C 5 alkoxyl-, C 3 -C 7 cycloakoxy-, halo-, oxo-, carboxy-, carboxy-C 1 -C 7 alkyl ester-, carboxy-C 3 -C 7 cylcloalkyl ester-, cyano-, trifluoromethyl-, pentafluoroethyl-, amino-, N,N-mono- or di-C 1 -C 20 alkylamino- or nitro-substituted phenyl-C 1 -C 5 alkyl, naphthyl-C 1 -C 5 alkyl, phenylcarbonyl-C 1 -C 5 alkyl, naphthylcarbonyl-C 1 -C 5 alkyl, pyrrolylalkyl, furanylalkyl, thiophenylalkyl, pyrazolylalkyl, imidazolylalkyl, oxazolylalkyl, thiazolylalkyl, isoxazolylalkyl, isothiazolylalkyl, 1,2,3-triazolylalkyl, 1,2,4-triazolylalkyl, 1,2,3-oxadiazolylalkyl, 1,3,4-oxadiazolylalkyl, 1,2,3-thiadiazolylalkyl, 1,3,4-thiadiazolylalkyl, indolylalkyl, pyridylalkyl, pyridazinylalkyl, pyrimidinylalkyl, pyridazinylalkyl, quinolinylalkyl, isoquinolinylalkyl, pyrrolyl, furanyl, thiophenyl, pyrazolyl, imidazolyl, oxazolyl, thiazolyl, isoxazolyl, isothiazolyl, 1,2,3-triazolyl, 1,2,4-triazolyl, 1,2,3-oxadiazolyl, 1,3,4-oxadiazolyl, 1,2,3-thiadiazolyl, 1,3,4-thiadiazolyl, indolyl, pyridyl, pyridazinyl, pyrimidinyl, pyridazinyl, quinolinyl or isoquinolinyl; R 4 , R 5 , R 6 and R 7 are each independently of the others hydrogen; C 1 -C 20 alkyl; C 3 -C 7 cycloalky; C 2 -C 20 alkenyl; C 4 -C 7 cycloalkenyl; C 2 -C 20 alkynyl; or C 4 -C 7 cycloalkynyl; and m and n are each independently of the other 0 or 1, for antimicrobial treatment of surfaces. The compounds exhibit a pronounced activity against pathogenic gram-positive and gram-negative bacteria, and also against yeasts and moulds. They are accordingly suitable for the antimicrobial treatment, especially preservation and disinfection, of surfaces.

  描述了化合物的使用，其中化合物R1、R2和R3分别独立地是氢；C1-C20烷基；C3-C7环烷基；C2-C20烯基；C4-C7环烯基；C2-C20炔基，C4-C7环炔基；或未取代或C1-C5烷基，C3-C7环烷基，C1-C5烷氧基，C3-C7环烷氧基，卤素，酮基，羧基，羧基-C1-C7烷酯基，羧基-C3-C7环烷基酯基，氰基，三氟甲基，五氟乙基，氨基，N，N-单或二-C1-C20烷基氨基或硝基取代的苯基-C1-C5烷基，萘基-C1-C5烷基，苯基羰基-C1-C5烷基，萘基羰基-C1-C5烷基，吡咯基烷基，呋喃基烷基，噻吩基烷基，吡唑基烷基，咪唑基烷基，噁唑基烷基，噻唑基烷基，异噁唑基烷基，异噻唑基烷基，1,2,3-三唑基烷基，1,2,4-三唑基烷基，1,2,3-噁二唑基烷基，1,3,4-噁二唑基烷基，1,2,3-噻二唑基烷基，1,3,4-噻二唑基烷基，吲哚基烷基，吡啶基烷基，吡啶并咪唑基烷基，嘧啶基烷基，吡啶并嘧啶基烷基，喹啉基烷基，异喹啉基烷基，吡咯基，呋喃基，噻吩基，吡唑基，咪唑基，噁唑基，噻唑基，异噁唑基，异噻唑基，1,2,3-三唑基，1,2,4-三唑基，1,2,3-噁二唑基，1,3,4-噁二唑基，1,2,3-噻二唑基，1,3,4-噻二唑基，吲哚基，吡啶基，吡啶并咪唑基，嘧啶基，吡啶并嘧啶基，喹啉基，异喹啉基；R4、R5、R6和R7分别独立地是氢；C1-C20烷基；C3-C7环烷基；C2-C20烯基；C4-C7环烯基；C2-C20炔基；或C4-C7环炔基；m和n分别独立地是0或1，用于对抗菌处理表面。这些化合物对致病的革兰氏阳性和阴性细菌，以及酵母和霉菌表现出显著的活性。因此，它们适用于对表面进行抗菌处理，特别是保护和消毒。
• 3-(4-hydroxy-3-methoxyphenyl)-1-(4-hydroxyphenyl)-1-propanone and its use in cosmetic and pharmaceutical preparations
  申请人：Schmaus Gerhard

  公开号：US20090208434A1

  公开（公告）日：2009-08-20

  The present invention concerns applications of the compound of formula 1 in cosmetic or pharmaceutical preparations.

  本发明涉及化合物1的在化妆品或药物制剂中的应用。
• [EN] SEMI-PERMANENT TATTOOS<br/>[FR] TATOUAGES SEMI-PERMANENTS
  申请人：INKBOX INK INC

  公开号：WO2022036113A1

  公开（公告）日：2022-02-17

  The present disclosure relates to semi-permanent tattoos, for example, compositions comprising semi-permanent colorants and semi-permanent colorant precursors that include derivatives of genipin and lawsone. In some embodiments, the composition comprises: a semi-permanent colorant present in an amount of about 10% to about 20% w/w of the composition; a solvent present in an amount of about 65% to about 80% w/w of the composition; and a thickening agent present in an amount of 0.01% to about 0.3% w/w of the composition. In some embodiments, the composition further includes one or more of a film-forming agent, a humectant, and a preservative.

  本公开涉及半永久纹身，例如，包括半永久颜料和半永久颜料前体的组合物，其中包括龙胆素和罗孚酮的衍生物。在某些实施例中，组合物包括：半永久颜料，其占组合物质量的约10％至约20％；溶剂，其占组合物质量的约65％至约80％；以及增稠剂，其占组合物质量的0.01％至约0.3％。在某些实施例中，组合物进一步包括一种或多种膜形成剂、保湿剂和防腐剂。