蔗糖苯甲酸酯 | 2425-84-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 蔗糖苯甲酸酯
• 英文名称: 2,3,4,6,1,3,4,6-octa-O-benzoylsucrose
• 英文别名: Sucrose octabenzoate；sucrose ocatbenzoate；SOB；(tetra-O-benzoyl-β-D-fructofuranosyl)-(tetra-O-benzoyl-α-D-glucopyranoside)；(Tetra-O-benzoyl-β-D-fructofuranosyl)-(tetra-O-benzoyl-α-D-glucopyranosid)；Sucrose octa (Benzoate)；[(2R,3R,4S,5R,6R)-3,4,5-tribenzoyloxy-6-[(2S,3S,4R,5R)-3,4-dibenzoyloxy-2,5-bis(benzoyloxymethyl)oxolan-2-yl]oxyoxan-2-yl]methyl benzoate
• CAS: 2425-84-5
• 化学式: C₆₈H₅₄O₁₉
• 分子量: 1175.17
• InChiKey: AKIVKIDZMLQJCH-KWOGCLBWSA-N

物化性质

• 密度：
  1.42±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  12.3
• 重原子数：
  87
• 可旋转键数：
  29
• 环数：
  10.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  238
• 氢给体数：
  0
• 氢受体数：
  19

反应信息

• 作为反应物：
  描述：

  蔗糖苯甲酸酯 在 异丙胺 作用下， 反应 80.0h， 以0.314 g的产率得到
  参考文献：
  名称：

  Sucrose octabenzoate: assignment of13C and1H resonances of the sucrose moiety and the13C resonances of the carbonyl carbons. Use of13C-n.m.r. spectroscopy for the study of selective deacylation

  摘要：

  Assignment of the 1H and 13C signals arising from the carbohydrate portion of sucrose octabenzoate has been achieved using homonuclear shift correlation experiments (COSY) and one-bond 1H-13C heteronuclear shift correlation measurements, respectively. The 13C resonances of the carbonyl carbon atoms of the eight benzoyl groups are readily distinguished for solutions in benzene-d6-pyridine-d5 (1:1), and have been assigned by means of three-bond 1H-13C shift correlation studies coupled with measurement of the 13C-n.m.r. spectrum of a sucrose octabenzoate specifically labelled with 13C in some of the carbonyl groups. With this assignment, products of partial deacylation of the octabenzoate may readily be identified by treatment with excess of benzoyl-carbonyl-13C chloride followed by measurement of the 13C-n.m.r. spectrum of the labelled sucrose octabenzoate, so prepared, in the carbonyl region.

  DOI：

  10.1016/0008-6215(90)80127-o
• 作为产物：
  描述：

  苯甲酰氯 、 蔗糖 在 sodium hydroxide 作用下， 以 水 、 环己酮 为溶剂， 反应 1.0h， 生成 蔗糖苯甲酸酯
  参考文献：
  名称：

  酯化化合物的制造方法

  摘要：

  本发明涉及一种酯化化合物的制造方法，其将结合有1个以上、12个以下的呋喃糖结构或吡喃糖结构中的至少一种的化合物酯化，得到酯化化合物，该酯化化合物为结合有1个以上、12个以下的呋喃糖结构或吡喃糖结构中的至少一种化合物与芳香族一元羧酸形成的酯，该制造方法包括对该酯化化合物的有机溶剂溶液进行吸附剂处理的工序，利用该制造方法，能够制造与非晶性树脂及结晶性树脂的相溶性优异，能够提高这些树脂的成型加工性、物性、柔韧性、抗冲击性等性能，能够抑制因加热导致的着色且热稳定性优异的酯化化合物。

  公开号：

  CN103450293B

文献信息

• [EN] SOLUTION COMPRISING FLUORESCENT DYE AS FIDUCIAL MARKER<br/>[FR] SOLUTION COMPRENANT UN MARQUEUR FLUORESCENT EN TANT QUE MARQUEUR DE RÉFÉRENCE
  申请人：UNIV DANMARKS TEKNISKE

  公开号：WO2019243422A1

  公开（公告）日：2019-12-26

  The present disclosure relates to a solution comprising a water insoluble carbohydrate and a fluorescent dye, such as a near infrared (NIR) contrast agent, wherein the solution sets under aqueous conditions, such as in vivo, to form e.g. a gel, a glass, a semi-solid, a solid, a crystal or any mixtures thereof. The disclosure further relates to preparation of such solution and use of such solution for in vivo imaging and/or guidance of surgery or interventional therapeutic procedures.

  本公开涉及一种溶液，包括一种水不溶性碳水化合物和一种荧光染料，例如一种近红外（NIR）对比剂，其中该溶液在水性条件下，例如在体内，形成例如凝胶、玻璃、半固体、固体、晶体或其任何混合物。该公开进一步涉及制备这种溶液和使用这种溶液进行体内成像和/或手术或介入治疗程序的指导。
• [EN] DISSACHARIDE FORMULATIONS FOR CONTROLLED DRUG RELEASE<br/>[FR] FORMULATIONS DE DISACCHARIDES POUR LA LIBÉRATION CONTRÔLÉE DE MÉDICAMENTS
  申请人：UNIV DENMARK TECH DTU

  公开号：WO2020249801A1

  公开（公告）日：2020-12-17

  The present invention relates to a composition comprising non-water soluble dissacharides and oil, a solvent and at least one pharmaceutical ingredient, wherein the composition contains at least two compounds selected from saccharides and lipid oils such as lactose octabenzoate Methyl hepta-O-isobutyryl-α,β-lactoside, α,β-Lactose octa para-iodobenzoate, 3-iodobenzyl hepta-O-isobutyryl-α,β-lactoside, lactose octapropionate, lactose octaisobutyrate, sucrose octabenzoate, glycerol trihexanoate, Glycerol trioctanoate, Glycerol tridecanoate, Lipiodol, ethyl myristate, ethyl palmitate, ethyl oleoate and wherein the composition is a liquid before administration into the human or animal body and increases in viscosity by more than 2,000 centipoise (cP) after administration.

  本发明涉及一种组合物，包括不溶于水的双糖和油、溶剂和至少一种药物成分，其中该组合物含有至少两种从糖类和脂肪油中选择的化合物，例如乳糖八苯甲酸酯、甲基庚烯基七-O-异丁酰-α，β-乳糖苷、α，β-乳糖八对碘苯甲酸酯、3-碘苯甲基七-O-异丁酰-α，β-乳糖苷、乳糖八丙酸酯、乳糖八异丁酸酯、蔗糖八苯甲酸酯、三己酸甘油酯、三辛酸甘油酯、三癸酸甘油酯、利碘油、肉豆蔻酸乙酯、棕榈酸乙酯、油酸乙酯，其中该组合物在注入人体或动物体内之前为液体，并在注入后黏度增加超过2,000厘泊（cP）。
• ULTRAVIOLET ABSORBING POLYMER, CELLULOSE ESTER OPTICAL FILM, METHOD OF PRODUCING CELLULOSE ESTER OPTICAL FILM, POLARIZING PLATE AND LIQUID CRYSTAL DISPLAY
  申请人：Suzuki Takayuki

  公开号：US20100104775A1

  公开（公告）日：2010-04-29

  Disclosed is an ultraviolet absorbing polymer which is characterized by being derived from an ethylenically unsaturated monomer having a partial structure represented by Formula (A) below in a molecule, and a monomer represented by Formula (B) below:

  本发明涉及一种紫外线吸收聚合物，其特征在于其由分子中具有以下式(A)所表示的部分结构的乙烯基不饱和单体和以下式(B)所表示的单体衍生而来：
• Manufacturing Method of Polarizing Plate Protective Film, Polarizing Plate Protective Film, Polarizing Plate, and Liquid Crystal Display Device
  申请人：Kasahara Kenzo

  公开号：US20100239787A1

  公开（公告）日：2010-09-23

  A process for producing a cellulose-ester-resin-containing protective film for polarizers through film formation by melt casting. The protective film diminishes long-period optical unevenness and suffers no unevenness even after long-term storage. Also provided are a protective film for polarizers, a polarizer employing the film, and a liquid-crystal display. The process for producing a protective film for polarizers is a process for producing by the melt casting method a polarizer-protective film containing a cellulose ester resin. The process for producing a protective film for polarizers is characterized in that the protective film contains at least one compound selected among compounds represented by the following general formula (I) and compounds having an acrylate or methacrylate group and a phenolic hydroxy group in the same molecule and that the protective film extruded from a casting die at a draw ratio of 10-30 during film formation by melt casting is transferred while holding/pressing it between a touch roll having an elastic surface and a cooling roll.

  一种通过熔融铸造进行膜形成的生产含有纤维素酯树脂的偏光片保护膜的方法。该保护膜减少了长周期光学不均匀性，并且即使长期存储后也不会出现不均匀性。还提供了用于偏光片的保护膜，使用该膜的偏光器和液晶显示器。生产偏光片保护膜的方法是通过熔融铸造法生产含有纤维素酯树脂的偏光片保护膜的方法。生产偏光片保护膜的方法的特点在于，保护膜包含以下通式（I）所代表的化合物中选择的至少一种化合物和在同一分子中具有丙烯酸酯或甲基丙烯酸酯基和酚羟基的化合物，并且在熔融铸造过程中，通过保持/压制保护膜在具有弹性表面的触摸辊和冷却辊之间转移，以拉伸比为10-30的方式挤出保护膜。
• CELLULOSE ACYLATE FILM, POLARIZING PLATE, AND LIQUID CRYSTAL DISPLAY USING THE SAME
  申请人：FUJIFILM Corporation

  公开号：US20160124123A1

  公开（公告）日：2016-05-05

  A cellulose acylate film, containing at least: a cellulose acylate; and a compound represented by the following Formula (I): wherein R 1 , R 3 and R 5 each independently designate a hydrogen atom, an alkyl group, a cycloalkyl group, an alkenyl group, or an aromatic group, which groups may have a further substituent; with the proviso that at least one of R 1 , R 3 and R 5 is an alkyl group substituted with a group having a ring structure or a cycloalkyl group, and the total number of the ring structures existing in R 1 , R 3 and R 5 is 3 or more.

  一种纤维素酰基膜，至少包含以下成分：纤维素酰基；以及下式（I）所表示的化合物：其中R1、R3和R5各自独立地表示氢原子、烷基、环烷基、烯基或芳基，这些基团可能具有进一步的取代基；但至少其中之一的R1、R3和R5是取代有环结构的烷基或环烷基，且存在于R1、R3和R5中的环结构总数为3个或更多。