21α-hydroxytaraxasterol | 1011717-97-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 21α-hydroxytaraxasterol
• 英文别名: 18α,19β-20(30)-taraxasten-3β,21α-diol；cichoridiol；(3S,4aR,6aR,6aR,6bR,8aS,10R,12R,12aR,14aR,14bR)-4,4,6a,6b,8a,12,14b-heptamethyl-11-methylidene-1,2,3,4a,5,6,6a,7,8,9,10,12,12a,13,14,14a-hexadecahydropicene-3,10-diol
• CAS: 1011717-97-7
• 化学式: C₃₀H₅₀O₂
• 分子量: 442.726
• InChiKey: BRSGFKGWKATOQT-KDQNFVFXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.8
• 重原子数：
  32
• 可旋转键数：
  0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  21α-hydroxytaraxasterol 、 乙酸酐 在 吡啶 作用下， 以2.73 mg的产率得到18α,19β-20(30)-taraxasten-3β,21α-diol diacetate
  参考文献：
  名称：

  α-Glucosidase Inhibitory Activity of Triterpenoids from Cichorium intybus

  摘要：

  Two new triterpenoids, 18 alpha, 19 beta-20(30)-taraxasten-3 beta,21 alpha-diol (cichoridiol) (1) and 17-epi-methyl-6-hydroxyangolensate (intybusoloid) (2), were obtained from the methanolic extract of seeds of Cichorium intybus along with 11 known compounds, lupeol (3), friedelin (4), beta-sitosterol (5), stigmasterol (6), betulinic acid (7), betulin (8), betulinaldehyde (9), syringic acid (10), vanillic acid (11) 6,7-dihydroxycoumarin (12), and methyl-alpha-D-galactopyranoside (13). Compounds 1, 1a, and 11 showed a good alpha-glucosidase inhibitory activity.

  DOI：

  10.1021/np800001v

文献信息

• α-Glucosidase Inhibitory Activity of Triterpenoids from <i>Cichorium intybus</i>
  作者：Atta-ur-Rahman、Seema Zareen、M. Iqbal Choudhary、M. Nadeem Akhtar、Shamsun Nahar Khan

  DOI：10.1021/np800001v

  日期：2008.5.1

  Two new triterpenoids, 18 alpha, 19 beta-20(30)-taraxasten-3 beta,21 alpha-diol (cichoridiol) (1) and 17-epi-methyl-6-hydroxyangolensate (intybusoloid) (2), were obtained from the methanolic extract of seeds of Cichorium intybus along with 11 known compounds, lupeol (3), friedelin (4), beta-sitosterol (5), stigmasterol (6), betulinic acid (7), betulin (8), betulinaldehyde (9), syringic acid (10), vanillic acid (11) 6,7-dihydroxycoumarin (12), and methyl-alpha-D-galactopyranoside (13). Compounds 1, 1a, and 11 showed a good alpha-glucosidase inhibitory activity.