3β,22β-dihydroxyolean-12-en-29-oic acid | 128301-32-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 3β,22β-dihydroxyolean-12-en-29-oic acid
• 英文别名: 22-epi-maytenfolic acid；3beta,22beta-Dihydroxyolean-12-en-29-oic acid；(2S,4R,4aR,6aR,6aS,6bR,8aR,10S,12aR,14bS)-4,10-dihydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-2-carboxylic acid
• CAS: 128301-32-6
• 化学式: C₃₀H₄₈O₄
• 分子量: 472.709
• InChiKey: JTBGJQZJEYVBJZ-FVRJYRSZSA-N

物化性质

• 沸点：
  584.1±50.0 °C(Predicted)
• 密度：
  1.14±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  34
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  77.8
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3β,22β-dihydroxyolean-12-en-29-oic acid 在 pyridinium chlorochromate 作用下， 以 乙醚 、 二氯甲烷 为溶剂， 反应 0.5h， 生成 Methyl-3,22-dioxoolean-12-en-29-oate
  参考文献：
  名称：

  Studies with tissue cultures of the Chinese herbal plant, Tripterygiumwilfordii. Isolation of metabolites of interest in rheumatoid arthritis, immunosuppression, and male contraceptive activity

  摘要：

  本文介绍了对中国草药植物雷公藤细胞培养系所产生代谢产物的详细研究。在二萜和三萜家族中，共分离出18种化合物，并进行了完整的表征。其中，有5种是新化合物，其结构是通过光谱分析、化学相关性和单晶X射线衍射相结合确定的。这些化合物在治疗类风湿性关节炎、皮肤过敏和男性避孕方面的应用价值也被指出。

  DOI：

  10.1139/v92-182

文献信息

• Polynucleotide binding complexes comprising sterols and saponin
  申请人：Nordic Vaccine Technology A/S

  公开号：EP2011517A1

  公开（公告）日：2009-01-07

  The present invention pertains to complexes comprising sterols and saponins. The complexes are capable of binding a genetic determinant including a polynucleotide. The complexes may further comprise a lipophilic moiety, optionally a lipophilic moiety comprising a contacting group and/or a targeting ligand, and/or a saccharide moiety. The complexes may further comprise an immunogenic determinant and/or an antigenic determinant and/or a medicament and/or a diagnostic compound. The complexes may in even further embodiments be encapsulated by an encapsulation agent including a biodegradable microsphere. The present invention also pertains to pharmaceutical compositions and methods of treatment of an individual by therapy and/or surgery, methods of cosmetic treatment, and diagnostic methods practised on the human or animal body.

  本发明涉及由甾醇和皂甙组成的复合物。这些复合物能够结合包括多核苷酸在内的遗传决定因子。复合物可进一步包含亲脂分子，可选择包含接触基团和/或靶向配体的亲脂分子和/或糖分子。复合物可进一步包括免疫原决定簇和/或抗原决定簇和/或药物和/或诊断化合物。在更进一步的实施方案中，复合物可被包括生物可降解微球在内的封装剂封装。本发明还涉及通过治疗和/或手术对个体进行治疗的药物组合物和方法、美容治疗方法以及对人体或动物体进行诊断的方法。
• POLYNUCLEOTIDE BINDING COMPLEXES COMPRISING STEROLS AND SAPONINS
  申请人：Nordic Vaccine Technology A/S

  公开号：EP1377320B1

  公开（公告）日：2008-10-01
• PARTICLE STRUCTURES COMPRISING STEROLS AND SAPONINS
  申请人：DALSGAARD Kristian

  公开号：US20110020226A1

  公开（公告）日：2011-01-27

  The present invention pertains to complexes comprising sterols and saponins. The complexes are capable of binding a genetic determinant including a polynucleotide. The complexes may further comprise a lipophilic moiety, optionally a lipophilic moiety comprising a contacting group and/or a targeting ligand, and/or a saccharide moiety. The complexes may further comprise an immunogenic determinant and/or an antigenic determinant and/or a medicament and/or a diagnostic compound. The complexes may in even further embodiments be encapsulated by an encapsulation agent including a biodegradable microsphere. The present invention also pertains to pharmaceutical compositions and methods of treatment of an individual by therapy and/or surgery, methods of cosmetic treatment, and diagnostic methods practised on the human or animal body.