3-Phenyl-5-sulfanyl-1,3,4-thiadiazole-2-thione potassium | 6336-51-2

• 物质功能分类: 有机原料 - 酮类化合物
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-Phenyl-5-sulfanyl-1,3,4-thiadiazole-2-thione potassium
• CAS: 6336-51-2
• 化学式: C8H6KN2S3
• 分子量: 265.4
• InChiKey: UNERKJMVFVZPDY-UHFFFAOYSA-N

物化性质

• 熔点：
  247°C

计算性质

• 辛醇/水分配系数(LogP)：
  2.95
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  105
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 危险类别码：
  R20/22,R36/37/38
• 海关编码：
  2934999090
• 安全说明：
  S26,S36/37,S9

制备方法与用途

金属指示剂用于光谱测定铋（Bi）、碲（Te）和硒（Se）。

反应信息

• 作为反应物：
  描述：

  3-Phenyl-5-sulfanyl-1,3,4-thiadiazole-2-thione potassium 、 2,6-二叔丁基苯酚 、 聚合甲醛 、 硫酸 在 乙醇 、 乙酸乙酯 、 水 、 magnesium sulfate 作用下， 以 乙醇 为溶剂， 反应 6.0h， 生成
  参考文献：
  名称：

  Process for inhibiting corrosion

  摘要：

  一种抑制腐蚀的方法涉及新的组合物，其包括有机物和腐蚀抑制剂，该腐蚀抑制剂具有以下化学式：##STR1## 其中，R.sup.1和R.sup.2可以相同或不同，且每个都是氢、C.sub.1-C.sub.15烷基、C.sub.3-C.sub.15烯基、C.sub.7-C.sub.10苯基烷基、具有6或10个芳香环碳原子的C.sub.6-C.sub.18芳基；或C.sub.5-C.sub.12环烷基；R.sup.3是氢或C.sub.1-C.sub.4烷基；n为0或1；A是具有5-7个环成员和1-4个氮原子的杂环环的残基，或者A是具有5-7个环成员和1-4个氮原子的杂环环的残基，并与另一个杂环环或碳环连接，或者A是碳环，特别是苯基或萘基环，其中R是一个或多个氢、C.sub.1-C.sub.15烷基、C.sub.1-C.sub.4卤代烷基、C.sub.1-C.sub.12烷氧基、C.sub.1-C.sub.12烷基硫基、苯基硫基、苄基硫基、C.sub.1-C.sub.12烷基磺酰基、苯基、C.sub.7-C.sub.15烷基苯基、C.sub.7-C.sub.10苯基烷基、C.sub.5-C.sub.8环烷基、卤素、NO.sub.2、CN、COOH、COO(C.sub.1-C.sub.12烷基)、OH、NH.sub.2、CONH.sub.2、NHR.sup.4、N(R.sup.4).sub.2、(CONH(R.sup.4)或--CON(R.sup.4).sub.2，其中R.sup.4是C.sub.1-C.sub.12烷基、被一个或多个O原子中断的C.sub.3-C.sub.12烷基、C.sub.5-C.sub.8环烷基、苄基、苯基或被卤素、C.sub.1-C.sub.4烷基、C.sub.1-C.sub.4烷氧基或NO.sub.2取代的苯基，或N(R.sup.4) .sub.2是吡咯烷基、哌啶基或吗啉基；前提是i) A不是苯并噻唑残基；ii) 当A是碳环且n为1时，A不是3,5-二叔丁基-4-羟基苯基，当n为1且A是被烷基取代的苯基时，R.sub.1和R.sub.2不是都是叔丁基。

  公开号：

  US05190723A1

文献信息

• AIR BAG GAS GENERATING AGENT
  申请人：OTSUKA KAGAKU KABUSHIKI KAISHA

  公开号：EP0763512A1

  公开（公告）日：1997-03-19

  An object of this invention is to provide an air bag azide-free gas generating composition which can pronouncedly reduce the concentrations of toxic components in the after gas, especially both concentrations of CO and NOx while retaining the desired advantages of azide-free gas generating compositions. The air bag gas generating composition of the invention is an azide-free gas generating composition comprising a nitrogen-containing organic compound and an oxidizing agent as active components, and further contains, as a burning catalyst, at least one metallic oxide selected from the group consisting of molybdenum oxides, tungsten oxides and metallic oxides having a BET specific surface area of at least 5 m2/g.

  本发明的目的是提供一种气囊无氮气体发生组合物，它可以明显降低尾气中有毒成分的浓度，特别是一氧化碳和氮氧化物的浓度，同时保留了无氮气体发生组合物所需的优点。本发明的气囊气体发生组合物是一种无叠氮气体发生组合物，包括作为活性成分的含氮有机化合物和氧化剂，以及作为燃烧催化剂的至少一种金属氧化物，这些金属氧化物选自钼氧化物、钨氧化物和 BET 比表面积至少为 5 m2/g 的金属氧化物。
• 4-SULFUR SUBSTITUTED PODOPHYLLOTOXIN DERIVATIVE AND PREPARATION METHOD THEREFOR AND USE THEREOF
  申请人：Tang, Yajie

  公开号：EP3686203A1

  公开（公告）日：2020-07-29

  Disclosed are a 4-sulfur substituted podophyllotoxin derivative and a synthetic method therefor and the use thereof. In the present invention, introducing heteroaromatic compounds with rigidity, such as 4-trifluoromethylpyridin-2-thiol, 4-trifluoromethyl-2-mercaptopyrimidine, and para-fluorothiophenol, respectively as substituent groups to position 4 of C ring of a podophyllotoxin or 4'-demethylepipodophyllotoxin, obtaining a podophyllotoxin derivative as shown in formula (V) with a significantly improved antitumour activity and reduced toxic side effects. Experiments of in vitro tumour cell activity inhibition indicate that the antitumour activity of the compound as shown in formula (V) of the present invention is significantly improved compared to that of the podophyllotoxin or 4'-demethylepipodophyllotoxin.

  本发明公开了一种4-硫取代的荚叶肿毒素衍生物及其合成方法和用途。在本发明中，将4-三氟甲基吡啶-2-硫醇、4-三氟甲基-2-巯基嘧啶和对氟苯硫酚等具有刚性的杂芳香族化合物分别作为取代基引入到荚膜多酚或4'-demethylepipodophyllotoxin的C环的第4位，得到如式（V）所示的荚膜多酚衍生物，其抗肿瘤活性显著提高，毒副作用降低。体外肿瘤细胞活性抑制实验表明，本发明的式(V)所示化合物的抗肿瘤活性与荚膜荚膜毒素或 4'-demethylepipodophyllotoxin的抗肿瘤活性相比有明显提高。
• 4-sulfur substituted podophyllotoxin derivative and preparation method therefor and use thereof
  申请人：Tang Yajie

  公开号：US11242354B2

  公开（公告）日：2022-02-08

  Disclosed are a 4-sulfur substituted podophyllotoxin derivative and a synthetic method therefor and the use thereof. In the present invention, introducing heteroaromatic compounds with rigidity, such as 4-trifluoromethylpyridin-2-thiol, 4-trifluoromethyl-2-mercaptopyrimidine, and para-fluorothiophenol, respectively as substituent groups to position 4 of C ring of a podophyllotoxin or 4demethylepipodophyllotoxin, obtaining a podophyllotoxin derivative as shown in formula (V) with a significantly improved antitumour activity and reduced toxic side effects. Experiments of in vitro tumour cell activity inhibition indicate that the antitumour activity of the compound as shown in formula (V) of the present invention is significantly improved compared to that of the podophyllotoxin or 4demethylepipodophyllotoxin.

  本发明公开了一种4-硫取代的荚叶肿毒素衍生物及其合成方法和用途。在本发明中，将4-三氟甲基吡啶-2-硫醇、4-三氟甲基-2-巯基嘧啶和对氟苯硫酚等具有刚性的杂芳香族化合物分别作为取代基引入到荚膜多酚或4-去甲基荚膜多酚的C环的第4位，得到如式（V）所示的荚膜多酚衍生物，其抗肿瘤活性显著提高，毒副作用降低。体外肿瘤细胞活性抑制实验表明，本发明的式(V)所示化合物的抗肿瘤活性与荚膜荚膜毒素或4demethylepipodophyllotoxin的抗肿瘤活性相比有明显提高。
• WATER-BASED BALLPOINT PEN
  申请人：THE PILOT INK CO., LTD.

  公开号：EP2281021B1

  公开（公告）日：2012-05-16
• 4-Sulfur Substituted Podophyllotoxin Derivative and Preparation Method Therefor and Use Thereof
  申请人：Tang Yajie

  公开号：US20200216462A1

  公开（公告）日：2020-07-09

  Disclosed are a 4-sulfur substituted podophyllotoxin derivative and a synthetic method therefor and the use thereof. In the present invention, introducing heteroaromatic compounds with rigidity, such as 4-trifluoromethylpyridin-2-thiol, 4-trifluoromethyl-2-mercaptopyrimidine, and para-fluorothiophenol, respectively as substituent groups to position 4 of C ring of a podophyllotoxin or 4 demethylepipodophyllotoxin, obtaining a podophyllotoxin derivative as shown in formula (V) with a significantly improved antitumour activity and reduced toxic side effects. Experiments of in vitro tumour cell activity inhibition indicate that the antitumour activity of the compound as shown in formula (V) of the present invention is significantly improved compared to that of the podophyllotoxin or 4 demethylepipodophyllotoxin.