5-ethyl-4-fluoro-2-(2-fluoropyridin-3-yloxy)phenol | 1269055-87-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 5-ethyl-4-fluoro-2-(2-fluoropyridin-3-yloxy)phenol
• 英文别名: 5-Ethyl-4-Fluoro-2-[(2-Fluoropyridin-3-Yl)oxy]phenol；5-ethyl-4-fluoro-2-(2-fluoropyridin-3-yl)oxyphenol
• CAS: 1269055-87-9
• 化学式: C₁₃H₁₁F₂NO₂
• 分子量: 251.233
• InChiKey: BJEMGBNLIALWCL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  42.4
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-氟-4-羟基-5-甲氧基苯乙酮 在 tetrafluoroboric acid 、 palladium on activated charcoal 、 氢气 、 三溴化硼 、 potassium hydroxide 、 锌 、 sodium nitrite 作用下， 以 乙醇 、 二氯甲烷 、 水 、 溶剂黄146 、 乙腈 为溶剂， 反应 2.75h， 生成 5-ethyl-4-fluoro-2-(2-fluoropyridin-3-yloxy)phenol
  参考文献：
  名称：

  From Triclosan toward the Clinic: Discovery of Nonbiocidal, Potent FabI Inhibitors for the Treatment of Resistant Bacteria

  摘要：

  In this paper, we present some elements of our optimization program to decouple triclosan's specific FabI effect from. its nonspecific cytotoxic component. The implementation of this strategy delivered highly specific, potent, and nonbiocidal new FabI inhibitors. We also disclose some preclinical data of one of their representatives, 83, a novel antibacterial compound active against resistant staphylococci and some clinically, relevant Gram negative bacteria that is currently undergoing clinical trails.

  DOI：

  10.1021/jm301113w

文献信息

• [EN] NOVEL ANTIBACTERIAL HYDROXYPHENYL COMPOUND<br/>[FR] NOUVEAU COMPOSÉ HYDROXYPHÉNYLIQUE ANTIBACTÉRIEN
  申请人：FAB PHARMA SAS

  公开号：WO2011026529A1

  公开（公告）日：2011-03-10

  The invention relates to a novel hydroxyphenyl compound, to the preparation of the compound and intermediates used therein, to the use of the compound as an antibacterial medicament and pharmaceutical compositions containing the compound.

  该发明涉及一种新型羟基苯化合物，以及制备该化合物和其中使用的中间体，将该化合物用作抗菌药物以及含有该化合物的制药组合物。
• Hydroxyphenyl Derivatives and Biological Applications Thereof
  申请人：Denis Alexis

  公开号：US20100041658A1

  公开（公告）日：2010-02-18

  The invention relates to hydroxyphenyl derivatives of formula (I); and uses thereof as anti-bacterial and/or anti-parasitic agents.

  本发明涉及公式（I）的羟基苯基衍生物；以及其作为抗菌和/或抗寄生虫剂的用途。
• NOVEL ANTIBACTERIAL HYDROXYPHENYL COMPOUND
  申请人：Gerusz Vincent

  公开号：US20120232155A1

  公开（公告）日：2012-09-13

  The invention relates to a novel hydroxyphenyl compound, to the preparation of the compound and intermediates used therein, to the use of the compound as an antibacterial medicament and pharmaceutical compositions containing the compound.

  本发明涉及一种新型的羟基苯化合物，其制备方法和中间体，以及将该化合物用作抗菌药物和含有该化合物的制药组合物。
• Hydroxyphenyl derivatives and biological applications thereof
  申请人：Denis Alexis

  公开号：US08722746B2

  公开（公告）日：2014-05-13

  The invention relates to hydroxyphenyl derivatives of formula (I); and uses thereof as anti-bacterial and/or anti-parasitic agents.

  本发明涉及公式（I）的羟基苯基衍生物；以及将其用作抗菌和/或抗寄生虫剂的用途。
• HYDROXYPHENYL DERIVATIVES AND BIOLOGICAL APPLICATIONS THEREOF
  申请人：FAB PHARMA S.A.S.

  公开号：US20140213589A1

  公开（公告）日：2014-07-31

  The invention relates to hydroxyphenyl derivatives of formula (I); and uses thereof as anti-bacterial and/or anti-parasitic agents.

  本发明涉及公式（I）的羟基苯基衍生物；以及它们作为抗菌和/或抗寄生虫剂的用途。