1-(2-Methoxyphenoxy)-3,7-dimethyl-2,6-octadien | 41515-54-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 1-(2-Methoxyphenoxy)-3,7-dimethyl-2,6-octadien
• 英文别名: 1-[(2E)-3,7-dimethylocta-2,6-dienoxy]-2-methoxybenzene
• CAS: 41515-54-2
• 化学式: C₁₇H₂₄O₂
• 分子量: 260.376
• InChiKey: QHWUEDQUHVBLTG-NTCAYCPXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  19
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  香叶基溴 、 木榴油 生成 1-(2-Methoxyphenoxy)-3,7-dimethyl-2,6-octadien
  参考文献：
  名称：

  Krimer,M.Z. et al., Journal of Organic Chemistry USSR (English Translation), 1973, vol. 9, p. 492 - 494

  摘要：

  DOI：

文献信息

• Phenyl-prenyl-ether derivatives for the treatment of cognitive neurodegenerative or neuronal diseases or disorders
  申请人：Neuropharma S.A.

  公开号：EP1886990A1

  公开（公告）日：2008-02-13

  The present invention is related to a family of phenyl-prenyl-ether derivatives of formula (I), and to their use in the treatment of cognitive, neurodegenerative or neuronal diseases or disorders, such as Alzheimer's disease or Parkinson's Disease. The present invention also relates to pharmaceutical compositions comprising the same. Further, the present invention is directed to the use of the compounds in the manufacture of a medicament for the treatment and/or prevention of a cognitive, neurodegenerative or neuronal disease or disorder.

  本发明涉及一类公式（I）的苯基-烯丙基-醚衍生物家族，以及它们在治疗认知、神经退行性或神经疾病或障碍，如阿尔茨海默病或帕金森病中的应用。本发明还涉及包含相同衍生物的制药组合物。此外，本发明针对化合物在制造用于治疗和/或预防认知、神经退行性或神经疾病或障碍的药物方面的使用。
• PHENYL-PRENYL-ETHER DERIVATIVES FOR THE TREATMENT OF COGNITIVE, NEURODEGENERATIVE OR NEURONAL DISEASES OR DISORDERS
  申请人：Martinez Gil Ana

  公开号：US20100267827A1

  公开（公告）日：2010-10-21

  The present invention is related to a family of phenyl-prenyl-ether derivatives of formula (I), and to their use in the treatment of cognitive, neurodegenerative or neuronal diseases or disorders, such as Alzheimer's disease or 5 Parkinson's Disease. The present invention also relates to pharmaceutical compositions comprising the same. Further, the present invention is directed to the use of the compounds in the manufacture of a medicament for the treatment and/or prevention of a cognitive, neurodegenerative or neuronal disease or disorder.

  本发明涉及一类公式（I）的苯基-异戊烯醚衍生物家族，以及它们在治疗认知、神经退行性或神经疾病或障碍，如阿尔茨海默病或帕金森病方面的应用。本发明还涉及包含这些化合物的制药组合物。此外，本发明还涉及将这些化合物用于制造治疗和/或预防认知、神经退行性或神经疾病或障碍的药物。
• [EN] PHENYL-PRENYL-ETHER DERIVATIVES FOR THE TREATMENT OF COGNITIVE, NEURODEGENERATIVE OR NEURONAL DISEASES OR DISORDERS<br/>[FR] DÉRIVÉS DE PHÉNYL-PRÉNYL-ÉTHER DESTINÉS AU TRAITEMENT DE MALADIES COGNITIVES OU NEURONALES, DE TROUBLES COGNITIFS OU NEURONAUX, OU DE TROUBLES OU MALADIES DE NEURODÉGÉNÉRESCENCE
  申请人：NEUROPHARMA SA

  公开号：WO2008015241A1

  公开（公告）日：2008-02-07

  [EN] The present invention is related to a family of phenyl-prenyl-ether derivatives of formula (I), and to their use in the treatment of cognitive, neurodegenerative or neuronal diseases or disorders, such as Alzheimer's disease or 5 Parkinson's Disease. The present invention also relates to pharmaceutical compositions comprising the same. Further, the present invention is directed to the use of the compounds in the manufacture of a medicament for the treatment and/or prevention of a cognitive, neurodegenerative or neuronal disease or disorder.
  [FR] La présente invention concerne une famille de dérivés de phényl-prényl-éther de formule (I) et leur utilisation pour traiter des maladies cognitives ou neuronales, des troubles cognitifs ou neuronaux, ou des troubles ou maladies de neurodégénérescence tels que la maladie d'Alzheimer ou la maladie de Parkinson. L'invention concerne également des compositions pharmaceutiques comprenant ces dérivés. L'invention a également pour objet l'utilisation des composés pour fabriquer un médicament destiné au traitement et/ou à la prévention d'une maladie cognitive ou neuronale, d'un trouble cognitif ou neuronal, ou d'un trouble ou d'une maladie de neurodégénérescence.