(3S)-all-trans-3-hydroxyretinal | 145681-21-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (3S)-all-trans-3-hydroxyretinal
• 英文别名: (2E,4E,6E,8E)-9-[(4S)-4-hydroxy-2,6,6-trimethylcyclohexen-1-yl]-3,7-dimethylnona-2,4,6,8-tetraenal
• CAS: 145681-21-6
• 化学式: C₂₀H₂₈O₂
• 分子量: 300.4
• InChiKey: QPRQNCDEPWLQRO-IRVDFSNZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Method for the production of vitamin a
  申请人：——

  公开号：US20040038209A1

  公开（公告）日：2004-02-26

  The present invention provides means and methods of transforming bacteria, fungi including yeast, animal and plant cells, seeds, tissues and whole plants in order to yield transformants capable of expressing &bgr;-carotene 15, 15′ dioxygenase and accumulating vitamin A aldehyde. The present invention further provides means and methods to biotechnically produce retinoids using cells, tissues, organs or whole organisms which natively or after transformation accumulate &bgr;-carotene or which take up &bgr;-carotene from the medium. The present invention also provides DNA molecules encoding &bgr;-carotene 15, 15′ dioxygenases derived from different sources and taxonomic groups of living organisms designed to be suitable for carrying out the method of the invention, and plasmids or vector systems comprising said molecules. Furthermore, the present invention provides transgenic bacteria, fungi including yeast, animal and plant cells, seeds, tissues and whole plants that display an improved nutritional quality or physiological condition and contain such DNA molecules and/or that have been generated by use of the methods of the present invention.

  本发明提供了转化细菌、真菌（包括酵母）、动物和植物细胞、种子、组织和整株植物的手段和方法，以便产生能够表达&bgr;-胡萝卜素15，15′二氧 化酶和积累维生素A醛的转化体。本发明进一步提供了利用细胞、组织、器官或整个生物体以生物技术生产视黄酸的手段和方法，这些细胞、组织、器官或整个生物体在原生或转化后积累&bgr;-胡萝卜素或从培养基中吸收&bgr;-胡萝卜素。本发明还提供了编码&bgr;-胡萝卜素 15，15′二氧 化酶的 DNA 分子，这些 DNA 分子来自不同来源和分类群的生物体，其设计适于实施本发明的方法，本发明还提供了包含上述分子的质粒或载体系统。此外，本发明还提供了转基因细菌、真菌（包括酵母）、动物和植物细胞、种子、组织和整株植物，它们显示出改善的营养质量或生理状况，并含有这种DNA分子和/或通过使用本发明的方法产生的这种DNA分子。
• METHOD FOR THE PRODUCTION OF VITAMIN A
  申请人：Syngenta Participations AG

  公开号：EP1244777A2

  公开（公告）日：2002-10-02
• DIOXYGENASES CATALYZING THE ASYMETRIC CLEAVAGE OF BETA-CAROTENE
  申请人：Syngenta Participations AG

  公开号：EP1242582A2

  公开（公告）日：2002-09-25
• Novel deoxygenases catalyzing cleavage of beta-carotene
  申请人：——

  公开号：US20030166595A1

  公开（公告）日：2003-09-04

  The present invention provides means and methods of transforming bacteria, fungi including yeast, animal and plant cells, seeds, tissues and whole plants in order to yield transformants capable of expressing novel &bgr;-carotene dioxygenases and accumulating important metabolites of the carotene/retinoid pathway such as vitamin A aldehyde and retinoic acid. The present invention further provides means and methods to biotechnically produce retinoids using cells, tissues, organs or whole organisms which natively or after transformation accumulate &bgr;-carotene or which take up &bgr;-carotene from the medium. The present invention also provides DNA molecules encoding symmetrically and asymmetrically cleaving &bgr;-carotene dioxygenases derived from different sources and taxonomic groups of living organisms designed to be suitable for carrying out the method of the invention, and plasmids or vector systems comprising said molecules. Furthermore, the present invention provides transgenic bacteria, fungi including yeast, animal and plant cells, seeds, tissues and whole plants that display an improved nutritional quality or physiological condition and contain such DNA molecules and/or that have been generated by use of the methods of the present invention.
• [EN] METHOD FOR THE PRODUCTION OF VITAMIN A<br/>[FR] PROCEDE DE FABRICATION DE VITAMINE A
  申请人：GREENOVATION PFLANZENBIOTECHNO

  公开号：WO2001048162A2

  公开（公告）日：2001-07-05

  The present invention provides means and methods of transforming bacteria, fungi including yeast, animal and plant cells, seeds, tissues and whole plants in order to yield transformants capable of expressing a β-carotene (15, 15') dioxygenase and accumulating vitamin A aldehyde. The present invention further provides means and methods to biotechnically produce retinoids using cells, tissues, organs or whole organisms which natively or after transformation accumulate β-carotene or which take up β-carotene from the medium. The present invention also provides DNA molecules encoding β-carotene (15, 15') dixoygenases derived from different sources and taxonomic groups of living organisms designed to be suitable for carrying out the method of the invention, and plasmids or vector systems comprising said molecules. Furthermore, the present invention provides transgenic bacteria, fungi including yeast, animal and plant cells, seeds, tissues and whole plants that display an improved nutritional quality or physiological condition and contain such DNA molecules and/or that have been generated by use of the methods of the present invention.