ethyl 2-acetyl-3-(2-methoxyphenyl)-4-nitrobutanoate | 184909-36-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: ethyl 2-acetyl-3-(2-methoxyphenyl)-4-nitrobutanoate
• CAS: 184909-36-2
• 化学式: C₁₅H₁₉NO₆
• 分子量: 309.319
• InChiKey: ASFMFKLHCQCVOP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  22
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  98.4
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  邻甲氧基苯甲醛 在 4-(triphenylphosphonio)phenolate 、 sodium hydroxide 作用下， 以 氯仿 为溶剂， 反应 1.0h， 生成 ethyl 2-acetyl-3-(2-methoxyphenyl)-4-nitrobutanoate
  参考文献：
  名称：

  Tetraarylphosphonium inner-salts (TAPIS) as both Lewis base catalyst and phase tag

  摘要：

  Tetraarylphosphonium inner-salts (TAPIS) have been designed, synthesized and verified as recyclable and reusable Lewis base catalysts. The resulted TAPIS catalyst has been successfully applied in Michael addition, cyanation and trifluoromethylation reactions. (C) 2017 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2017.06.015

文献信息

• Efficient Method for the Synthesis of Michael Adducts Using Kaolin Preloaded with KOH
  作者：G. Srihari、M. Marthanda Murthy

  DOI：10.1080/00397910802439191

  日期：2009.2.9

  Abstract Michael addition of various active methylene compounds to β-nitrostyrenes is efficiently catalyzed by using Kaolin preloaded with KOH in acetonitrile at room temperature with moderate to good yields.

  摘要 在室温下，在乙腈中预载 KOH 的高岭土可以有效地催化各种活性亚甲基化合物与 β-硝基苯乙烯的迈克尔加成反应，收率适中。
• Tetraarylphosphonium inner-salts (TAPIS) as both Lewis base catalyst and phase tag
  作者：Shuhui Guo、Xueling Mi

  DOI：10.1016/j.tetlet.2017.06.015

  日期：2017.7

  Tetraarylphosphonium inner-salts (TAPIS) have been designed, synthesized and verified as recyclable and reusable Lewis base catalysts. The resulted TAPIS catalyst has been successfully applied in Michael addition, cyanation and trifluoromethylation reactions. (C) 2017 Elsevier Ltd. All rights reserved.