(24Z)-3-oxo-11R,12S-diacetoxylanosta-8,24-dien-26-oic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (24Z)-3-oxo-11R,12S-diacetoxylanosta-8,24-dien-26-oic acid
• 英文别名: tyromycic acid B；(Z,6R)-6-[(5R,10S,11R,12S,13R,14S,17R)-11,12-diacetyloxy-4,4,10,13,14-pentamethyl-3-oxo-1,2,5,6,7,11,12,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl]-2-methylhept-2-enoic acid
• 化学式: C₃₄H₅₀O₇
• 分子量: 570.767
• InChiKey: ABJXQXSTZIZQEY-WCLUPPNXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  41
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.76
• 拓扑面积：
  107
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  1-(4-溴苯基)-2-羟基乙基-1-酮 、 (24Z)-3-oxo-11R,12S-diacetoxylanosta-8,24-dien-26-oic acid 在 potassium carbonate 作用下， 以 丙酮 为溶剂， 反应 3.0h， 以9.4 mg的产率得到(24Z)-3-oxo-11R,13S-diacetoxylanosta-8,24-dien-26-oic acid p-bromophenacyl ester
  参考文献：
  名称：

  Tyromycic Acids B−E, New Lanostane Triterpenoids from the Mushroom Tyromyces fissilis

  摘要：

  Four new triterpenoids, tyromycie acids B-E (1-4), were isolated from a methanol-soluble extract of the fruit bodies of the Japanese inedible mushroom Tyromyces fissilis. Tyromycic acids B-D possess a lanostane skeleton, while tyromycic acid E is based on a rare 14(13-->12)abeo-lanostane skeleton. Their structures were determined by spectral data analysis and by single-crystal X-ray crystallography.

  DOI：

  10.1021/np030264+

文献信息

• Tyromycic Acids B−E, New Lanostane Triterpenoids from the Mushroom <i>Tyromyces fissilis</i>
  作者：Dang Ngoc Quang、Toshihiro Hashimoto、Masami Tanaka、Shigeru Takaoka、Yoshinori Asakawa

  DOI：10.1021/np030264+

  日期：2004.2.1

  Four new triterpenoids, tyromycie acids B-E (1-4), were isolated from a methanol-soluble extract of the fruit bodies of the Japanese inedible mushroom Tyromyces fissilis. Tyromycic acids B-D possess a lanostane skeleton, while tyromycic acid E is based on a rare 14(13-->12)abeo-lanostane skeleton. Their structures were determined by spectral data analysis and by single-crystal X-ray crystallography.