(E)-3-Cyclohex-1-enyl-1,5-diphenyl-pent-1-en-4-yn-3-ol

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂醇
• 英文名称: (E)-3-Cyclohex-1-enyl-1,5-diphenyl-pent-1-en-4-yn-3-ol
• 英文别名: (E)-3-(cyclohexen-1-yl)-1,5-diphenylpent-1-en-4-yn-3-ol
• 化学式: C₂₃H₂₂O
• 分子量: 314.427
• InChiKey: AEDNSQCROIMKGJ-FBMGVBCBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  1-cyclohexene-1-carboxaldehyde 、 苯乙炔 在 potassium tert-butylate 作用下， 以 四氢呋喃 为溶剂， 反应 0.02h， 以80%的产率得到(E)-3-Cyclohex-1-enyl-1,5-diphenyl-pent-1-en-4-yn-3-ol
  参考文献：
  名称：

  KO^tBu-Promoted Three-Component Coupling of Aldehydes and Alkynes:  Highly Efficient Synthesis of 1-En-4-yn-3-ols and 2-En-4-yn-1-ols

  摘要：

  A (KOBu)-Bu-t-promoted three-component coupling reaction of aldehydes and alkynes without a transition-metal catalyst was developed in which the sequential addition/isomerization/addition processes take place in one pot. This reaction could be developed into a straightforward and effective method for rapid access to stereodefined (E)-1-en-4-yn-3-ol and (Z)2-en-4-yn-1-ol compounds.

  DOI：

  10.1021/jo0604078

文献信息

• KO<i>^t</i>Bu-Promoted Three-Component Coupling of Aldehydes and Alkynes:  Highly Efficient Synthesis of 1-En-4-yn-3-ols and 2-En-4-yn-1-ols
  作者：Shao-Hua Wang、Yong-Qiang Tu、Peng Chen、Xiang-Dong Hu、Fu-Min Zhang、Ai-Xia Wang

  DOI：10.1021/jo0604078

  日期：2006.5.1

  A (KOBu)-Bu-t-promoted three-component coupling reaction of aldehydes and alkynes without a transition-metal catalyst was developed in which the sequential addition/isomerization/addition processes take place in one pot. This reaction could be developed into a straightforward and effective method for rapid access to stereodefined (E)-1-en-4-yn-3-ol and (Z)2-en-4-yn-1-ol compounds.