3-(2,2,2-trifluoroethoxy)pyridine

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-(2,2,2-trifluoroethoxy)pyridine
• 化学式: C₇H₆F₃NO
• 分子量: 177.126
• InChiKey: APIGBXXRWJDRLW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  22.1
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  3-(2,2,2-trifluoroethoxy)pyridine 在 间氯过氧苯甲酸 作用下， 以 二氯甲烷 为溶剂， 生成 1-Oxido-3-(2,2,2-trifluoroethoxy)pyridin-1-ium
  参考文献：
  名称：

  PREPARATION OF FUSED AZOLE DERIVATIVES AS NOVEL DIACYLGLYCERIDE O-ACYLTRANSFERASE 2 INHIBITORS

  摘要：

  Provided are compounds of Formula I, Formula Ia and Formula Ib and the pharmaceutically acceptable salts, esters, and prodrugs thereof, which are DGAT2 inhibitors. Also provided are methods of making compounds of Formula I, Formula Ia and Formula Ib, pharmaceutical compositions comprising compounds of Formula I, Formula Ia and Formula Ib, and methods of using these compounds to treat hepatic steatosis, nonalcoholic steatohepatitis (NASH), hepatic fibrosis, type-2 diabetes mellitus, obesity, hyperlipidemia, hypercholesterolemia, atherosclerosis, cognitive decline, dementia, cardiorenal diseases such as chronic kidney diseases and heart failure and related diseases and conditions, comprising administering a compound of Formula I, Ia and Ib and the pharmaceutically acceptable salts, esters, and prodrugs thereof, to a patient in need thereof.

  公开号：

  WO2024118858A1
• 作为产物：
  描述：

  3-溴吡啶 、 2,2,2-三氟乙醇 在 C₄₃H₅₉NO₂PPd⁽¹⁺⁾*CH₃O₃S^(1-) 、 caesium carbonate 作用下， 以 甲苯 为溶剂， 反应 4.0h， 以43%的产率得到3-(2,2,2-trifluoroethoxy)pyridine
  参考文献：
  名称：

  钯催化CO交叉偶联合成氟化烷基芳基醚。

  摘要：

  在本文中，我们报告了一种高效的方案，可使用市售的预催化剂t BuBrettPhos Pd G3和Cs 2 CO 3在甲苯中将（杂）芳基溴化物与氟化醇交叉偶联。这种钯催化的偶联反应具有反应时间短，对官能团的耐受性强以及与富电子和贫电子（杂）芳烃相容的特点。该方法通过与[ 18 F]三氟乙醇交叉偶联而获得18 F-标记的三氟乙基醚。

  DOI：

  10.1021/acs.orglett.0c02347

文献信息

• 3-substituted pyridine compounds and related synthesis
  申请人：——

  公开号：US20010006805A1

  公开（公告）日：2001-07-05

  The present invention relates to 3-substituted and 2,3-disubstituted pyridine compounds which are useful as intermediates in the synthesis of pyridylsulfonylurea herbicides. The invention also relates to arylation of alcohols using a pyridinediazonium salt. More particularly the arylation process of the instant invention relates to the synthesis of 2,3-disubstituted pyridine compounds via anhydrous diazotization of 3-aminopyridines to form a diazonium salt intermediate that is then reacted with the appropriate alcohol to produce the desired product. The invention additionally relates to pyridine-3-diazonium salt intermediates.

  本发明涉及3-取代和2,3-二取代的吡啶化合物，这些化合物在吡啶磺酰脲除草剂的合成中作为中间体有用。本发明还涉及使用吡啶重氮盐进行醇的芳基化反应。更具体地说，本发明的芳基化过程涉及通过无水重氮化3-氨基吡啶来合成2,3-二取代的吡啶化合物，以形成重氮盐中间体，然后与适当的醇反应以产生所需的产物。本发明还涉及吡啶-3-重氮盐中间体。
• Diazonium salts which are intermediates for 3-substituted pyridines
  申请人：Syngenta Participations AG

  公开号：US06710180B2

  公开（公告）日：2004-03-23

  The present invention relates to 3-substituted and 2,3-disubstituted pyridine compounds which are useful as intermediates in the synthesis of pyridylsulfonylurea herbicides. The invention also relates to arylation of alcohols using a pyridinediazonium salt. More particularly the arylation process of the instant invention relates to the synthesis of 2,3-disubstituted pyridine compounds via anhydrous diazotization of 3-amninopyridines to form a diazonium salt intermediate that is then reacted with the appropriate alcohol to produce the desired product. The invention additionally relates to pyridine-3-diazonium salt intermediates.

  本发明涉及3-取代和2,3-双取代吡啶化合物，可用作合成吡啶磺酰脲除草剂的中间体。本发明还涉及使用吡啶重氮盐对醇进行芳基化反应。特别是，本发明的芳基化过程涉及通过3-氨基吡啶的无水重氮化形成重氮盐中间体，然后与适当的醇反应，以产生所需的产物的2,3-双取代吡啶化合物的合成。本发明还涉及吡啶-3-重氮盐中间体。
• Viral polymerase inhibitors
  申请人：Boehringer Ingelheim International GmbH

  公开号：EP2626354A1

  公开（公告）日：2013-08-14

  An enantiomer, diastereoisomer or tautomer of a compound, represented by formula I: wherein A, B, R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10 are as defined herein, or a salt or ester thereof, as an inhibitor of HCV NS5B polymerase.

  式 I 所代表化合物的对映体、非对映异构体或同系物： 其中 A、B、R1、R2、R3、R4、R5、R6、R7、R8、R9 和 R10 如本文所定义，或其盐或酯，作为 HCV NS5B 聚合酶的抑制剂。
• NON-AQUEOUS SECONDARY BATTERY AND NON-AQUEOUS ELECTROLYTE
  申请人：Asahi Kasei Kabushiki Kaisha

  公开号：EP4009398A1

  公开（公告）日：2022-06-08

  Provided is a non-aqueous secondary battery that includes a positive electrode, a negative electrode, a separator, and a non-aqueous electrolyte. The positive electrode includes LiNixCoyMnzO2 (0.7 < x < 0.9, 0 < y < 0.2, 0 < z < 0.2) as a lithium-containing metal oxide, and when the positive electrode before and after cycle testing of the non-aqueous secondary battery is analyzed by powder X-ray diffraction using Cu-Kα radiation, the rate of change of the c-axis lattice constant is 1.0% or less. The non-aqueous electrolyte includes 5-20% by volume of acetonitrile and has an ion conductivity of at least 10 mS/cm and less than 15 mS/cm at 20°C.

  本文提供了一种非水二次电池，它包括正极、负极、隔膜和非水电解液。正极包括作为含锂金属氧化物的 LiNixCoyMnzO2 (0.7 < x < 0.9, 0 < y < 0.2, 0 < z < 0.2)，当使用 Cu-Kα 辐射对非水性二次电池循环测试前后的正极进行粉末 X 射线衍射分析时，c 轴晶格常数的变化率为 1.0% 或更小。非水电解液包括 5-20%（体积）的乙腈，在 20°C 时离子电导率至少为 10 mS/cm，小于 15 mS/cm。
• 10.1002/ejoc200900303
  作者：Vukga, Daniela、Legros, Juelien、Crousse, Benoit、Bonnet-Delpon, Daniele

  DOI：10.1002/ejoc200900303

  日期：——