N-(4-hydroxy-2,3-dimethylphenyl)cinnamamide

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: N-(4-hydroxy-2,3-dimethylphenyl)cinnamamide
• 英文别名: N-(4-hydroxy-2,3-dimethylphenyl)-3-phenylprop-2-enamide
• 化学式: C₁₇H₁₇NO₂
• 分子量: 267.327
• InChiKey: APLXOZPBILBPSM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-(4-hydroxy-2,3-dimethylphenyl)cinnamamide 在 lead(IV) tetraacetate 作用下， 以 溶剂黄146 为溶剂， 生成 N-(2,3-dimethyl-4-oxocyclohexa-2,5-dien-1-ylidene)-3-phenylprop-2-enamide
  参考文献：
  名称：

  Reaction of N-[aryl(benzylidene, phenoxy)acetyl]-1,4-benzoquinone imines with sodium 4-methylbenzenesulfinate

  摘要：

  The reaction of N-[aryl(phenoxy, benzylidene)acetyl]-1,4-benzoquinone imines with sodium 4-methylbenzenesulfinates takes different addition patterns, depending on the LUMO energy and charge distribution over the quinoid ring of the initial quinone imine.

  DOI：

  10.1134/s1070428014100054
• 作为产物：
  描述：

  3-硝基邻二甲苯 在 苯基溴化硒 、 rhodium on carbon 、 碳酸氢钠 、 一水合肼 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 乙醚 为溶剂， 反应 8.0h， 生成 N-(4-hydroxy-2,3-dimethylphenyl)cinnamamide
  参考文献：
  名称：

  Redox‐Neutral Selenium‐Catalysed Isomerisation of para ‐Hydroxamic Acids into para ‐Aminophenols

  摘要：

  AbstractA selenium‐catalysed para‐hydroxylation of N‐aryl‐hydroxamic acids is reported. Mechanistically, the reaction comprises an N−O bond cleavage and consecutive selenium‐induced [2,3]‐rearrangement to deliver para‐hydroxyaniline derivatives. The mechanism is studied through both 18O‐crossover experiments as well as quantum chemical calculations. This redox‐neutral transformation provides an unconventional synthetic approach to para‐aminophenols.

  DOI：

  10.1002/anie.202100801

文献信息

• Redox‐Neutral Selenium‐Catalysed Isomerisation of <i>para</i> ‐Hydroxamic Acids into <i>para</i> ‐Aminophenols
  作者：Hsiang‐Yu Chuang、Manuel Schupp、Ricardo Meyrelles、Boris Maryasin、Nuno Maulide

  DOI：10.1002/anie.202100801

  日期：2021.6.14

  AbstractA selenium‐catalysed para‐hydroxylation of N‐aryl‐hydroxamic acids is reported. Mechanistically, the reaction comprises an N−O bond cleavage and consecutive selenium‐induced [2,3]‐rearrangement to deliver para‐hydroxyaniline derivatives. The mechanism is studied through both 18O‐crossover experiments as well as quantum chemical calculations. This redox‐neutral transformation provides an unconventional synthetic approach to para‐aminophenols.
• Reaction of N-[aryl(benzylidene, phenoxy)acetyl]-1,4-benzoquinone imines with sodium 4-methylbenzenesulfinate
  作者：S. A. Konovalova、A. P. Avdeenko、V. M. Vasil’eva、A. L. Yusina

  DOI：10.1134/s1070428014100054

  日期：2014.10

  The reaction of N-[aryl(phenoxy, benzylidene)acetyl]-1,4-benzoquinone imines with sodium 4-methylbenzenesulfinates takes different addition patterns, depending on the LUMO energy and charge distribution over the quinoid ring of the initial quinone imine.