4-methoxy-3-methyl-pent-1-ene

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-methoxy-3-methyl-pent-1-ene
• 英文别名: 4-Methoxy-3-methylpent-1-ene；4-methoxy-3-methylpent-1-ene
• 化学式: C₇H₁₄O
• 分子量: 114.188
• InChiKey: ASYPTOFNOLPSCA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  二甲氧基乙烷 、 1-(trimethylsilyl)but-2-ene 在 titanocene(IV) triflate 作用下， 以 硝基甲烷-d3 为溶剂， 反应 0.1h， 以90%的产率得到4-methoxy-3-methyl-pent-1-ene
  参考文献：
  名称：

  均相催化。[TiCp 2（CF 3 SO 3）2 ]催化剂用于烯丙基硅烷与原酸酯，缩醛，缩酮和羰基化合物的樱井反应。

  摘要：

  对于与原酸酯，缩醛，缩酮，醛和酮反应的各种烯丙基硅烷，已经探索了[TiCp 2（CF 3 SO 3）2 ]催化剂在樱井反应中的有效性。

  DOI：

  10.1016/s0040-4039(00)79336-1

文献信息

• Origin of Syn/Anti Diastereoselectivity in Aldehyde and Ketone Crotylation Reactions:  A Combined Theoretical and Experimental Study
  作者：Lutz F. Tietze、Tom Kinzel、Stefan Schmatz

  DOI：10.1021/ja062528v

  日期：2006.9.1

  diastereoselectivities of (a) multicomponent crotylation (MCC) reactions of simple aliphatic aldehydes and ketones and (b) of acetal substitution (AS) reactions of aldehyde dimethyl acetals with E- and Z-configurated crotyl trimethylsilane to give homoallylic methyl ethers bearing two newly formed stereogenic centers. We found that corresponding MCC and AS reactions give nearly equal syn/anti ratios. While the crotylations

  我们报告了实验确定和计算预测的非对映选择性 (a) 简单脂肪醛和酮的多组分巴豆化 (MCC) 反应和 (b) 醛二甲基缩醛与 E-和 Z-配置的巴豆基三甲基硅烷的缩醛取代 (AS) 反应给出带有两个新形成的立体中心的同烯丙基甲基醚。我们发现相应的 MCC 和 AS 反应给出几乎相等的顺/反比。虽然乙醛和丙醛的巴豆化主要产生 E 构型硅烷的顺式产物和 Z 构型硅烷的反产物，但发现顺式产物是新戊醛巴豆化的主要产物，而与底物双键几何结构无关。使用丁酮作为底物，在两种情况下都发现反产物是主要产物。通过在二氯甲烷溶液 (PCM/UAKS) 中采用 B3LYP/6-31+G(d) 理论水平的计算研究，我们发现巴豆基硅烷对 O-甲基取代的羧基离子的攻击解释了实验观察到的选择性，表明这些巴豆化实际上是通过这种离子中间体在 S(N)1 型反应中进行的。相关开放过渡态结构的比较导致观察到的选择性的合理化。对于
• [DE] SUBSTITUIERTE 2-PHENYL-3(2H)-PYRIDAZINONE<br/>[EN] SUBSTITUTED 2-PHENYL-3(2H)-PYRIDAZINONES<br/>[FR] 2-PHENYLE-3(2H)-PYRIDAZINONES SUBSTITUEES
  申请人：BASF AKTIENGESELLSCHAFT

  公开号：WO1999014201A1

  公开（公告）日：1999-03-25

  (DE) Substituierte 2-Phenyl-3(2H)-pyridazinone (I) und deren Salze, wobei n = 0, 1, 2; R1 = C1-C4-Alkyl, C1-C4-Halogenalkyl; R2 = H, Halogen; R3 = Halogen, CN; R4 = H, NO2, CN, CHO, NH-OH, C1-C4-Alkyl, C1-C4-Halogenalkyl, -OR5, -CH=N-OR6, -CH=C(R7)-CO-OR8, -CO-OR9, C1-C6-Alkyl-SO2-NH, Di(C1-C6-Alkylsulfonyl)amino oder (a); R5 = C1-C6-Alkyl, C3-C6-Alkenyl, C3-C6-Alkinyl, (C1-C6-Alkoxy)-carbonyl-C1-C4-alkyl, (C3-C6-Alkenyloxy)carbonyl-C1-C4-alkyl, (C3-C6-Alkinyloxy)carbonyl-C1-C4-alkyl, C1-C4-Alkoxy-(C1-C4-alkoxy)carbonyl-C1-C4alkyl; R6 = H, C1-C4-Alkyl, Hydroxycarbonyl-C1-C4-alkyl, (C1-C4-Alkoxy)-carbonyl-C1-C4-alkyl; R7 = H, Halogen, C1-C4-Alkyl; R8 = H, C1-C6-Alkyl; R9 = H, C1-C6-Alkyl, C3-C6-Alkenyl, C3-C6-Alkinyl, C1-C4-Alkoxy-C1-C4-alkoxy, Hydroxycarbonyl-C1-C4-alkyl, (C1-C6-Alkoxy)-carbonyl-C1-C4-alkyl, (C3-C6-Alkenyloxy)carbonyl-C1-C4-alkyl, (C3-C6-Alkinyloxy)carbonyl-C1-C4-alkyl, C1-C4-Alkoxy-(C1-C4-alkoxy)carbonyl-C1-C4-alkyl; R10 = H, C1-C6-Alkyl, COOH, (C1-C6-Alkoxy)carbonyl; Verwendung: als Herbizide; zur Desikkation/Defoliation von Pflanzen.(EN) The invention concerns substituted 2-phenyl-3(2H)-pyridazinones of formula (I), and their salts. In said formula, n = 0, 1, 2; R1 = alkyl C1-C4, alkyl halide C1-C4; R2 = H, halogen; R3 = halogen, CN; R4 = H, NO2, CN, CHO, NH-OH, alkyl C1-C4, alkyl halide C1-C4, -OR5, -CH=N-OR6, -CH=C(R7)-CO-OR8, -CO-OR9, alkyl C1-C6 -SO2-NH, di(alkylsulphonyl C1-C6)amino or (a); R5 = alkyl C1-C6, alkenyl C3-C6, alkinyl C3-C6, (alkoxy C1-C6)carbonyl-alkyl C1-C4, (alkenyloxy C3-C6)carbonyl-alkyl C1-C4, (alkinyloxy C3-C6)carbonyl-alkyl C1-C4, alkoxy C1-C4-(alkoxy C1-C4) carbonyl-alkyl C1-C4; R6 = H, alkyl C1-C4, hydroxycarbonyl-alkyl C1-C4, (alkoxy C1-C4) carbonyl-alkyl C1-C4; R7 = H, halogen, alkyl C1-C4; R8 = H, alkyl C1-C6; R9 = H, alkyl C1-C6, alkenyl C3-C6, alkinyl C3-C6, alkoxy-C1-C4-alkoxy C1-C4, hydroxycarbonyl-alkyl C1-C4, (alkoxy C1-C6)carbonyl-alkyl C1-C4, (alkenyloxy C3-C6)carbonyl-alkyl C1-C4, (alkinyloxy C3-C6)carbonyl-alkyl C1-C4, alkoxy C1-C4-(alkoxy C1-C4)carbonyl-alkyl C1-C4; R10 = H, alkyl C1-C6, COOH, (alkoxy C1-C6)carbonyl. Said compounds are used as herbicides for desiccation/defoliation of plants.(FR) L'invention concerne des 2-phényle-3(2H)-pyridazinones substituées de la formule (I), ainsi que leurs sels. Dans cette formule, n = 0, 1, 2; R1 = alkyle C1-C4, halogénure d'alkyle C1-C4; R2 = H, halogène; R3 = halogène, CN; R4 = H, NO2, CN, CHO, NH-OH, alkyle C1-C4, halogénure d'alkyle C1-C4, -OR5, -CH=N-OR6, -CH=C(R7)-CO-OR8, -CO-OR9, alkyle C1-C6-SO2-NH, di(alkylesulfonyle C1-C6)amino ou (a); R5 = alkyle C1-C6, alkényle C3-C6, alkinyle C3-C6, (alcoxy C1-C6)carbonyle-alkyle C1-C4, (alkényloxy C3-C6)carbonyle-alkyle C1-C4, (alkinyloxy C3-C6)carbonyle-alkyle C1-C4, alcoxy C1-C4-(alcoxy C1-C4)carbonyle-alkyle C1-C4; R6 = H, alkyle C1-C4, hydroxycarbonyle-alkyle C1-C4, (aloxy C1-C4)carbonyle-alkyle C1-C4; R7 = H, halogène, alkyle C1-C4; R8 = H, alkyle C1-C6; R9 = H, alkyle C1-C6, alkényle C3-C6, alkinyle C3-C6, alcoxy C1-C4-alcoxy C1-C4, hydroxycarbonyle-alkyle C1-C4, (alcoxy C1-C6)carbonyle-alkyle C1-C4, (alkényloxy C3-C6)carbonyle-alkyle C1-C4, (alkinyloxy C3-C6)carbonyle-alkyle C1-C4, alcoxy C1-C4-(alcoxy C1-C4)carbonyle-alkyle C1-C4; R10 = H, alkyle C1-C6, COOH, (alcoxy C1-C6)carbonyle. Ces composés s'utilisent comme herbicides, pour la dessiccation/défoliation de plantes.

  这些化合物具有抗逆性，可能用于植物的除草除菌。取代 capitalize substituements renovation 和去分化。
• SUBSTITUIERTE 2-PHENYL-3(2H)-PYRIDAZINONE
  申请人：BASF AKTIENGESELLSCHAFT

  公开号：EP1034166A1

  公开（公告）日：2000-09-13
• Protective Effects of Curcumin Against Hemorrhagic Stroke Injury
  申请人：Georgia Regents Research Institute, Inc.

  公开号：US20150087705A1

  公开（公告）日：2015-03-26

  Disclosed herein are compounds, compositions and methods for preventing and treating diseases such as intracerebral hemorrhage, cancer, or conditions associated with damaged cells, activated lymphocytes, or microbial products. The disclosed compounds are curcumin analogs. The curcumin analogs possess anti-inflammatory and antioxidant properties, which in part, reduce AP-1 and NF-κB activity.
• Homogeneous catalysis. Use of the [TiCp2(CF3SO3)2] catalyst for the sakurai reaction of allylic silanes with orthoesters, acetals, ketals and carbonyl compounds.
  作者：T. Keith Hollis、N.P. Robinson、John Whelan、B. Bosnich

  DOI：10.1016/s0040-4039(00)79336-1

  日期：1993.7

  The effectiveness of the [TiCp2(CF3SO3)2] catalyst for the Sakurai reaction has been explored for a variety of allylic silanes reacting with orthoesters, acetals, ketals, aldehydes and ketones.

  对于与原酸酯，缩醛，缩酮，醛和酮反应的各种烯丙基硅烷，已经探索了[TiCp 2（CF 3 SO 3）2 ]催化剂在樱井反应中的有效性。