5-(2-furoyl)amino-3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 5-(2-furoyl)amino-3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole
• 英文别名: N-[3-(1-methyl-3,6-dihydro-2H-pyridin-4-yl)-1H-indol-5-yl]furan-2-carboxamide
• 化学式: C₁₉H₁₉N₃O₂
• 分子量: 321.379
• InChiKey: BDKXHAQHZVTDNE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  61.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  呋喃甲酰氯 、 5-氨基吲哚 在 氢氧化钾 、 ammonium hydroxide 、 三乙胺 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 生成 5-(2-furoyl)amino-3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole
  参考文献：
  名称：

  Methods of treating or ameliorating the symptoms of common cold or

  摘要：

  这项发明提供了治疗或改善普通感冒或过敏性鼻炎症状的方法，包括向需要的哺乳动物施用一种5-羟色胺5-HT.sub.1F激动剂。

  公开号：

  US05962473A1

文献信息

• Use of serotonin 5-HT1F agonists for the prevention of migraine
  申请人：ELI LILLY AND COMPANY

  公开号：EP0832650A3

  公开（公告）日：1998-09-02

  This invention provides methods for the prevention of migraine which comprises administering to a mammal in need thereof a serotonin 5-HT1F agonist.

  这项发明提供了预防偏头痛的方法，包括向需要的哺乳动物施用一种5-HT1F受体激动剂。
• Use of a serotonin 5-HTlf agonist in the manufacture of a medicament for treating or ameliorating the symptoms of common cold or allergic rhinitis
  申请人：ELI LILLY AND COMPANY

  公开号：EP0824917A3

  公开（公告）日：2000-08-30

  This invention provides methods for the treatment or amelioration of the symptoms of the common cold or allergic rhinitis which comprises administering to a mammal in need thereof a serotonin 5-HT1F agonist.

  这项发明提供了治疗或缓解普通感冒或过敏性鼻炎症状的方法，包括向需要的哺乳动物施用一种5-HT1F受体激动剂。
• 5-Substituted-3-(1,2,3,6-tetrahydropyridin-4-yl)-and
  申请人：Eli Lilly and Company

  公开号：US05708008A1

  公开（公告）日：1998-01-13

  This invention provides novel 5-HT.sub.1F agonists of Formula I ##STR1## where A--B, R, R.sup.1 and X are as defined in the specification, which are useful for the treatment of migraine and associated disorders.

  这项发明提供了新颖的Formula I的5-HT.sub.1F激动剂，其中A-B、R、R.sup.1和X如规范中所定义，对治疗偏头痛及相关疾病有用。
• Methods of treating or ameliorating the symptoms of common cold or allergic rhinitis with serotonin 5-HT1F agonists
  申请人：Eli Lilly and Company

  公开号：US06380201B1

  公开（公告）日：2002-04-30

  This invention provides methods for the treatment or amelioration of the symptoms of the common cold or allergic rhinitis which comprises administering to a mammal in need thereof a serotonin 5-HT1F agonist.

  本发明提供了一种治疗或缓解普通感冒或过敏性鼻炎症状的方法，包括向需要该治疗的哺乳动物施用一种5-羟色胺5-HT1F激动剂。
• 5-substituted-3-(1,2,3,6-tetrahydropyridin-4-yl)-and
  申请人：Eli Lilly and Company

  公开号：US05962474A1

  公开（公告）日：1999-10-05

  This invention provides novel 5-HT.sub.1F agonists of Formula I ##STR1## where A--B, R,R.sup.1 and X are as defined in the specification, which are useful for the treatment of migraine and associated disorders.

  本发明提供了式I的新型5-HT.sub.1F激动剂：##STR1## 其中A-B、R、R.sup.1和X如规范中所定义，这些激动剂对于治疗偏头痛及其相关疾病是有用的。