丙烯基-三聚乙二醇-丙烯基 | 90736-68-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 丙烯基-三聚乙二醇-丙烯基
• 英文名称: triethylene glycol diallyl ether
• 英文别名: 4,7,10,13-Tetraoxahexadeca-1,15-diene；3-[2-[2-(2-prop-2-enoxyethoxy)ethoxy]ethoxy]prop-1-ene
• CAS: 90736-68-8
• 化学式: C₁₂H₂₂O₄
• 分子量: 230.304
• InChiKey: ZEWNANDAGSVPKE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  16
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  36.9
• 氢给体数：
  0
• 氢受体数：
  4

安全信息

• 储存条件：
  存储条件：2-8°C，密封保存，避免潮湿。

制备方法与用途

丙烯基-聚乙二醇3-丙烯基是一种PROTAC连接子，属于聚乙二醇类。它可以用于合成PROTAC分子。

反应信息

• 作为反应物：
  描述：

  丙烯基-三聚乙二醇-丙烯基 在 Grubbs catalyst first generation 、 lithium perchlorate 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 3.0h， 生成 1,4,7,10-tetraoxacyclotetradec-12-ene
  参考文献：
  名称：

  Synthesis of an A/B/C Triblock Copolymer for Battery Materials Applications

  摘要：

  An A/B/C triblock copolymer has been synthesized having potential applications as a self-contained nanoscale battery. A new organometallic compound was synthesized which serves as the anode. The polyelectrolyte block of the copolymer is an unsaturated polyether. The last block acts as the template to form metal oxide clusters and functions as the cathode. The triblock copolymer was synthesized by ring-opening metathesis polymerization using Grubbs's catalyst. GPC and NMR were used to monitor the polymerization. H-1 and C-13 NMR, FTIR, UV-vis, GPC with light scattering, and XPS were used to characterize the synthesized polymer.

  DOI：

  10.1021/ma035668n
• 作为产物：
  描述：

  3-溴丙烯 、 三乙二醇 在 sodium hydride 作用下， 以 四氢呋喃 、 mineral oil 为溶剂， 以85%的产率得到丙烯基-三聚乙二醇-丙烯基
  参考文献：
  名称：

  通过亲核性环氧树脂开环轻松合成羟基取代的噻咯酮醚

  摘要：

  抽象的 以一步法制备标题硫杂冠醚，得到一系列具有两个易于取代的未取代羟基的独特大环。另外，制备了由库克森的鸟笼二酮衍生的环氧化物和大环化合物。环氧化物合成的亲核开环可以在点击化学的框架内分类。令人惊讶地，首次制备了一些制备的烯丙基取代的聚乙二醇以及双环氧化物，尤其是硫类似物。 以一步法制备标题硫杂冠醚，得到一系列具有两个易于取代的未取代羟基的独特大环。另外，制备了由库克森的鸟笼二酮衍生的环氧化物和大环化合物。环氧化物合成的亲核开环可以在点击化学的框架内分类。令人惊讶地，首次制备了一些制备的烯丙基取代的聚乙二醇以及双环氧化物，尤其是硫类似物。

  DOI：

  10.1055/s-0037-1612249

文献信息

• Application of HPLC for the screening of separation of new macrocyclic systems
  作者：Monika Stefaniak、Jarosław Romański

  DOI：10.1080/10426507.2016.1255622

  日期：2017.2.1

  GRAPHICAL ABSTRACT ABSTRACT The efficient synthesis of new macrocyclic systems via nucleophilic ring opening reaction of epoxides by thiols was described. Initially new macrocyclic compounds were obtained as a mixture of diastereomers. Preparative thin layer chromatography was applied to separate meso and pairs of enantiomer. The identification of products using a chiral HPLC column and mass spectroscopy

  图形摘要 摘要描述了通过硫醇对环氧化物的亲核开环反应有效合成新的大环系统。最初以非对映异构体的混合物形式获得新的大环化合物。应用制备薄层色谱分离内消旋和对映异构体对。使用手性 HPLC 柱和质谱法对产品进行鉴定。
• An Expedient Synthesis of Monodispersed Oligo(ethylene glycols)
  作者：Tak Hang Chan、Brendan A. Burkett

  DOI：10.1055/s-2004-816007

  日期：——

  A convenient approach to the synthesis of oligo(ethylene glycols) under phase transfer conditions is described. Oligo(ethylene glycols) (x = 7-12) are obtained in excellent yields and high purity via modular, bi-directional elongation of readily available ethylene glycol bis-tosylates.

  描述了一种在相转移条件下合成低聚（乙二醇）的简便方法。Oligo(ethylene glycols) (x = 7-12) 通过容易获得的乙二醇二甲苯磺酸酯的模块化双向延伸以优异的收率和高纯度获得。
• Specific <i>Z</i>-Selectivity in the Oxidative Isomerization of Allyl Ethers to Generate Geometrically Defined <i>Z</i>-Enol Ethers Using a Cobalt(II)(salen) Complex Catalyst
  作者：Guanxin Huang、Miaolin Ke、Yuan Tao、Fener Chen

  DOI：10.1021/acs.joc.0c00004

  日期：2020.4.17

  synthesis of the geometrically less stable Z-enol ethers is challenging. An efficient Z-selective oxidative isomerization process of allyl ethers catalyzed by a cobalt(II) (salen) complex using N-fluoro-2,4,6-trimethylpyridinium trifluoromethanesulfonate (Me3NFPY•OTf) as an oxidant has been developed. Thermodynamically less stable Z-enol ethers were prepared in excellent yields with high geometric control.

  烯醇醚的结构基序存在于许多高度氧化的生物活性天然产物和药物中。几何上不稳定的Z-烯醇醚的合成具有挑战性。已经开发出一种有效的Z-烯丙基醚（Zalen）配合物使用N-氟-2,4,6-三甲基吡啶三氟甲磺酸盐（Me3NFPY•OTf）作为氧化剂催化的烯丙基醚的Z选择氧化异构化方法。热力学稳定性较低的Z-烯醇醚以高收率和高几何控制制备。该方法还证明了在室温下控制二烯丙基醚的Z-选择性异构化反应的有效性。该催化体系提供了另一种途径来扩展烯丙基醚的传统还原异构化。
• SUBSTITUTED OR UNSUBSTITUTED ALLYL GROUP-CONTAINING MALEIMIDE COMPOUND, PRODUCTION METHOD THEREFOR, AND COMPOSITION AND CURED PRODUCT USING SAID COMPOUND
  申请人：DIC CORPORATION

  公开号：US20200325101A1

  公开（公告）日：2020-10-15

  Bismaleimides (BMI) exhibit excellent heat resistance (high Tg and high resistance to thermal decomposition) compared to epoxy resins and phenolic resins, and therefore, in recent years, more attention is paid to bismaleimides as a resin material for the next-generation devices represented by SiC power semiconductors, in addition to the investigation on the use of bismaleimides for electronic material applications. As such, conventional BMI's are known as highly heat-resistant resins; however, there is a demand for a resin having higher heat resistance for advanced material applications and the like. Thus, an object of the invention is to provide a novel maleimide compound having superior heat resistance. Disclosed is a substituted or unsubstituted allyl group-containing maleimide compound having a structure with three or more benzene rings, having one or more groups each having a substituted or unsubstituted allyl group, and having one or more maleimide groups.

  亚苯基马来酰亚胺化合物，具有三个或更多苯环的结构，含有一个或多个取代或未取代的烯丙基团，以及一个或多个马来酰亚胺基团，具有卓越的耐热性。
• [EN] MULTIVALENT INHIBITORS OF SERUM AMYLOID P COMPONENT<br/>[FR] INHIBITEURS POLYVALENTS DE LA COMPOSANTE P DES AMYLOIDES SERIQUES
  申请人：THERACARB INC

  公开号：WO2004099173A1

  公开（公告）日：2004-11-18

  Novel glycerol cyclic pyruvate derivates were prepared and demonstrated to inhibit the binding of an immobilized D-proline derivative to serum amyloid P component (SAP) have been prepared. As such, the compounds of the invention are useful for treating amyloidosis and diseases associated with amyloidosis, for example Alzheimer's disease and maturity onset diabetes mellitus.

  新型甘油环状丙酮衍生物已经制备并证明能够抑制固定化D-脯氨酸衍生物与血清淀粉样蛋白P成分（SAP）的结合。因此，本发明的化合物可用于治疗淀粉样变性和与淀粉样变性相关的疾病，例如阿尔茨海默病和成人发病型糖尿病。