(Z)-1,4,7,10-Tetraoxa-cyclotetradec-12-ene | 192047-91-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (Z)-1,4,7,10-Tetraoxa-cyclotetradec-12-ene
• 英文别名: 1,4,7,10-Tetraoxacyclotetradec-12-ene
• CAS: 192047-91-9
• 化学式: C₁₀H₁₈O₄
• 分子量: 202.251
• InChiKey: PBRYDFKPWILCGH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  36.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  丙烯基-三聚乙二醇-丙烯基 在 ruthenium alkylidene complex 作用下， 反应 1.0h， 以45%的产率得到(Z)-1,4,7,10-Tetraoxa-cyclotetradec-12-ene
  参考文献：
  名称：

  新一代钌基烯烃复分解催化剂的合成及活性，与1,3-二甲磺酰基-4,5-二氢咪唑-2-亚烷基配体配合使用。

  摘要：

  [公式：参见文字]从RuCl2（= CHPh）（PCy3）2 2开始，制备了一个新的1,3-二甲磺酰基-4,5-二氢咪唑-2-亚乙基取代的钌基络合物9a-c。与母体复合物2和先前开发的复合物3相比，这些耐空气和水的复合物在升高的温度下显示出更高的闭环易位活性。可以使用低至0.05mol％的催化剂负载量。

  DOI：

  10.1021/ol990909q

文献信息

• Synthesis and Activity of a New Generation of Ruthenium-Based Olefin Metathesis Catalysts Coordinated with 1,3-Dimesityl-4,5-dihydroimidazol-2-ylidene Ligands
  作者：Matthias Scholl、Sheng Ding、Choon Woo Lee、Robert H. Grubbs

  DOI：10.1021/ol990909q

  日期：1999.9.1

  [formula: see text] A new family of 1,3-dimesityl-4,5-dihydroimidazol-2-ylidene-substituted ruthenium-based complexes 9a-c has been prepared starting from RuCl2(=CHPh)(PCy3)2 2. These air- and water-tolerant complexes were shown to exhibit an increased ring-closing metathesis activity at elevated temperature when compared to that of the parent complex 2 and the previously developed complex 3. In many

  [公式：参见文字]从RuCl2（= CHPh）（PCy3）2 2开始，制备了一个新的1,3-二甲磺酰基-4,5-二氢咪唑-2-亚乙基取代的钌基络合物9a-c。与母体复合物2和先前开发的复合物3相比，这些耐空气和水的复合物在升高的温度下显示出更高的闭环易位活性。可以使用低至0.05mol％的催化剂负载量。
• Increased ring closing metathesis activity of ruthenium-based olefin metathesis catalysts coordinated with imidazolin-2-ylidene ligands
  作者：Matthias Scholl、Tina M. Trnka、John P. Morgan、Robert H. Grubbs

  DOI：10.1016/s0040-4039(99)00217-8

  日期：1999.3

  The novel air and water tolerant, imidazolinylidene-substituted ruthenium-based complex 3, has been prepared starting from RuCl2(=CHPh)(PCy3)(2) 2 and shown to exhibit increased ring-closing metathesis activity at elevated temperature compared to that of the parent complex 2. Di-, tri-, and even tetra-substituted cycloolefins were successfully prepared from corresponding diene precursors using catalytic amounts of 3 in moderate to excellent yields. (C) 1999 Elsevier Science Ltd. All rights reserved.
• Oligomers as Intermediates in Ring-Closing Metathesis
  作者：Jay C. Conrad、Melanie D. Eelman、João A. Duarte Silva、Sebastien Monfette、Henrietta H. Parnas、Jennifer L. Snelgrove、Deryn E. Fogg

  DOI：10.1021/ja067531t

  日期：2007.2.1

  Oligomerization is kinetically favored in RCM reactions catalyzed by RuCl2(PCy3)(IMes)(=CHPh), for a range of unhindered , alpha,omega-dienes leading to large or medium-sized rings, even at dilutions designed to minimize intermolecular reaction. Reversible metathesis (i.e., ethenolysis) is inhibited by rapid volatilization of ethylene. At appropriately high dilutions, however, the RCM products are efficiently liberated by backbiting.