potassium all-trans-retinoate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: potassium all-trans-retinoate
• 英文别名: potassium(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1yl)nona-2,4,6,8-tetraenoate；potassium retinoate；potassium;(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoate
• 化学式: C₂₀H₂₇O₂*K
• 分子量: 338.531
• InChiKey: VJSUZBVKKWCWLJ-ABAXVIISSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  1.27
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  40.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  potassium all-trans-retinoate 、 3,4-二羟基-2'-氯苯乙酮 在 盐酸 作用下， 以 六甲基磷酰三胺 为溶剂， 生成 4-(all-trans-RETINOYLOXYACETYL)-CATECHOL
  参考文献：
  名称：

  Retinoic acid derivatives

  摘要：

  本发明公开了全反式视黄酸的酯和酰胺，可用于治疗痤疮。

  公开号：

  US04055659A1
• 作为产物：
  描述：

  维A酸 在 potassium hydroxide 作用下， 以 正己烷 、 水 为溶剂， 反应 0.08h， 生成 potassium all-trans-retinoate
  参考文献：
  名称：

  신규화합물 Potassium all-trans retinoate 및 Potassium 9-cis retinoate의 합성방법

  摘要：

  通过在all-trans维甲酸和9-cis维甲酸中分别添加己烷，然后加入KOH，合成钾all-trans维甲酸和钾9-cis维甲酸的步骤，提供了一种合成钾all-trans维甲酸和钾9-cis维甲酸的方法，通过测量9-cis β-胡萝卜素在口服时在肠道中的吸收率，其LogP值>9，大部分不被吸收而被排泄，从而防止了口服给药的可能性，可用于心血管治疗剂，即冠心病治疗剂和心绞痛治疗剂，具有降低癌症和心血管疾病风险的强效抗氧化剂效果。

  公开号：

  KR102271364B1

文献信息

• MULTILAYER FILM AND INTERMEDIATE FILM FOR LAMINATED GLASS FORMED OF SAME
  申请人：Kuraray Co., Ltd.

  公开号：EP3064352A1

  公开（公告）日：2016-09-07

  There is provided a multilayer film comprising a layer (X) containing a polyvinyl acetal (I) having an acetalization degree of 55 to 80 mol%, a content of a vinyl ester monomer unit of 0.1 to 1.5 mol% and a viscosity-average degree of polymerization of 1,400 to 5,000; and a layer (Y) containing a polyvinyl acetal (II) having an acetalization degree of 70 to 85 mol%, a content of a vinyl ester monomer unit of 5 to 15 mol% and a viscosity-average degree of polymerization of 1,400 to 5,000, wherein the multilayer film satisfies formulas (1) and (2): (A-B)/A < 0.80 (1) and 1.00 × 10-2 < (b/y)/(a/x) < 2.00 × 10-1 (2). There is thus provided a film which exhibits sufficient sound-absorbability, resistance to coloration by heating, reduction in foreign materials (undissolved materials) and excellent recyclability.

  提供了一种多层薄膜，包括一层（X），该层含有聚乙烯醇缩醛（I），其缩醛度为 55 至 80 摩尔%，乙烯基酯单体单元含量为 0.1 至 1.5 摩尔%，粘度平均聚合度为 1,400 至 5,000 度；以及一层（Y），该层含有聚乙烯醇缩醛（II），其缩醛度为 70 至 85 摩尔%。5 mol%，平均聚合粘度为 1,400 至 5,000 度；以及一层 (Y)，该层含有聚乙烯醇缩醛 (II)，其缩醛度为 70 至 85 mol%，乙烯基酯单体单元含量为 5 至 15 mol%，平均聚合粘度为 1,400 至 5,000 度，其中多层膜满足式 (1) 和 (2)：(A-B)/A < 0.80 (1)和 1.00 × 10-2 < (b/y)/(a/x) < 2.00 × 10-1 (2)。因此，本发明提供的薄膜具有足够的吸音性、耐加热着色性、减少异物（未溶解物质）和出色的可回收性。
• BINDER FOR FORMATION OF CERAMIC OR FOR USE IN CONDUCTIVE PASTE, AND USE OF SAME
  申请人：Kuraray Co., Ltd.

  公开号：EP3109263A9

  公开（公告）日：2017-04-12

  There is provided a binder for ceramic formation or a conductive paste, comprising polyvinyl acetal having a degree of acetalization of from 50 to 85 mol%, a content of vinyl ester monomer unit of from 0.1 to 20 mol%, and having a viscosity-average degree of polymerization of from 200 to 5000, wherein a peak-top molecular weight (A) as measured by a differential refractive index detector and a peak-top molecular weight (B) as measured by an absorptiometer (measurement wavelength: 280 nm) in gel permeation chromatographic measurement of the polyvinyl acetal heated at 230°C for 3 hours satisfy a formula (1) (A-B)/A < 0.60 and the polyvinyl acetal has an absorbance in the peak-top molecular weight (B) of from 0.50 × 10-3 to 1.00 × 10-2.

  提供了一种用于陶瓷成型或导电浆料的粘结剂，它包括聚乙烯醇缩醛，其缩醛度为 50 至 85 摩尔%，乙烯基酯单体单元含量为 0.其中，在凝胶渗透色谱法测量在 230°C 下加热 3 小时的聚乙烯醇缩醛时，用差分折射率检测器测得的峰顶分子量 (A) 和用吸收仪（测量波长：280 纳米）测得的峰顶分子量 (B) 满足式 (1) (A-B)/A < 0.60，且聚乙烯醇缩醛的峰顶分子量（B）吸光度为 0.50 × 10-3 至 1.00 × 10-2。
• INTERLAYER FOR LAMINATED GLASS
  申请人：Kuraray Co., Ltd.

  公开号：EP3109213A1

  公开（公告）日：2016-12-28

  An objective of the invention is to provide: an interlayer which is for use in a laminated glass comprising a polyvinyl acetal, which is less discolored by heating and contains less foreign materials (undissolved materials), and in which light-diffusing fine particles are dispersed in a non-agglomerated state. Another objective is to provide a laminated glass, in which, even when the interlayer film for a laminated glass is produced after repeated heating, light-diffusing fine particles are dispersed in a non-agglomerated state, and which exhibits excellent penetration resistance, excellent transparency and excellent light-diffusing properties with the use of the interlayer film. There is provided an interlayer film for a laminated glass comprising a polyvinyl acetal with an acetalization degree of 60 to 80 mol%, a content of a vinyl ester monomer unit of 0.1 to 20 mol% and a viscosity-average degree of polymerization of 1400 to 4000, and light-diffusing fine particles, wherein a difference absolute value between a refractive index of the light-diffusing fine particles and a refractive index of the composition free from the light-diffusing fine particles is 0.20 or more and a haze as measured in accordance with JIS K 7105 for a laminated glass prepared by sandwiching the interlayer film for a laminated glass between two glass sheets with a thickness of 3 mm is 20 % or less, and the interlayer film for a laminated glass satisfies formulas (1) and (2): A−B/A<0.80 1.00×10−2

  本发明的一个目的是提供一种用于夹层玻璃的中间膜，该中间膜由聚乙烯醇缩醛组成，加热后变色较少，含有较少的异物（未溶解物），并且其中的光扩散微粒以非团聚状态分散。另一个目的是提供一种夹层玻璃，在使用该夹层玻璃用中间膜时，即使在反复加热后生成夹层玻璃用中间膜，光扩散细微颗粒也能以非团聚状态分散，并且具有优异的抗渗透性、优异的透明度和优异的光扩散特性。提供了一种夹层玻璃用中间膜，该中间膜由聚乙烯醇缩醛（缩醛度为 60 至 80 摩尔%，乙烯基酯单体单元含量为 0.1 至 20 摩尔%，粘度-平均聚合度为 1400 至 4000）和光扩散微粒组成，其中光扩散微粒的折射率与不含光扩散微粒的组合物的折射率之差的绝对值为 0.根据 JIS K 7105 测量，将夹层玻璃用中间膜夹在厚度为 3 mm 的两片玻璃之间制备的夹层玻璃的雾度为 20 % 或以下，且夹层玻璃用中间膜满足公式 (1) 和 (2)：A−B/A<0.80 1.00×10−2
• Multilayer film and interlayer film for laminated glass therefrom
  申请人：KURARAY CO., LTD.

  公开号：US10016959B2

  公开（公告）日：2018-07-10

  There is provided a multilayer film comprising a layer (X) containing a polyvinyl acetal (I) having an acetalization degree of 55 to 80 mol %, a content of a vinyl ester monomer unit of 0.1 to 1.5 mol % and a viscosity-average degree of polymerization of 1,400 to 5,000; and a layer (Y) containing a polyvinyl acetal (II) having an acetalization degree of 70 to 85 mol %, a content of a vinyl ester monomer unit of 5 to 15 mol % and a viscosity-average degree of polymerization of 1,400 to 5,000, wherein the multilayer film satisfies formulas (1) and (2): (A−B)/A<0.80  (1) and 1.00×10−2<(b/y)/(a/x)<2.00×10−1  (2). There is thus provided a film which exhibits sufficient sound-absorbability, resistance to coloration by heating, reduction in foreign materials (undissolved materials) and excellent recyclability.

  提供了一种多层薄膜，其中一层（X）含有聚乙烯醇缩醛（I），其缩醛度为 55 至 80 摩尔 %，乙烯基酯单体单元含量为 0.1 至 1.5 mol %，平均聚合粘度为 1,400 至 5,000 ；以及一层（Y），该层含有聚乙烯醇缩醛（II），其缩醛度为 70 至 85 mol %，乙烯基酯单体单元含量为 5 至 15 mol %，平均聚合粘度为 1,400 至 5,000 ，其中多层膜满足式（1）和（2）： (a-b)/a<0.80 (1) 和 1.00×10-2<(b/y)/(a/x)<2.00×10-1 (2)。 这样就提供了一种薄膜，它具有足够的吸音性、耐加热着色性、减少异物（未溶解物质）和出色的可回收性。
• Interlayer film for laminated glass
  申请人：KURARAY CO., LTD.

  公开号：US10259198B2

  公开（公告）日：2019-04-16

  An interlayer for a laminated glass is provided. The interlayer film contains (a) a polyvinyl acetal with an acetalization degree of 60 to 80 mol %, a content of a vinyl ester monomer unit of from 0.1 to 20 mol %, and a viscosity-average degree of polymerization of from 1400 to 4000, and (b) light-diffusing fine particles in which an absolute value difference between a refractive index of the light-diffusing fine particles and a refractive index of the intrlayer excluding the light-diffusing fine particles is 0.20 or more and a haze as measured in accordance with JIS K 7105 for a laminated glass prepared by sandwiching the interlayer film between two glass sheets with a thickness of 3 mm is 20% or less.

  提供了一种用于夹层玻璃的中间膜。该中间膜包含：(a) 聚乙烯醇缩醛，其缩醛度为 60 至 80 摩尔%，乙烯基酯单体单元含量为 0.1 至 20 摩尔%，粘度-平均聚合度为 1400 至 4000；(b) 光扩散微粒，其中光扩散微粒的折射率与不包括光扩散微粒的中间膜的折射率之间的绝对值差为 0.20 或更高，并且在厚度为 3 毫米的两片玻璃之间夹入中间膜而制备的夹层玻璃中，根据 JIS K 7105 测量的雾度为 20% 或更低。