hexahydrofarnesoyl dopamine

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: hexahydrofarnesoyl dopamine
• 英文别名: N-[2-(3,4-dihydroxyphenyl)ethyl]-3,7,11-trimethyldodecanamide
• 化学式: C₂₃H₃₉NO₃
• 分子量: 377.568
• InChiKey: RVBBPCZGDPSTPQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.9
• 重原子数：
  27
• 可旋转键数：
  13
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  69.6
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3,7,11-三甲基月桂酸钠 在 草酰氯 、 三乙胺 、 N,N-二甲基甲酰胺 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 4.5h， 生成 hexahydrofarnesoyl dopamine
  参考文献：
  名称：

  AMPHIPHILE PRODRUGS

  摘要：

  公开号：

  EP2393472B1

文献信息

• [EN] AMPHIPHILE PRODRUGS<br/>[FR] PROMÉDICAMENTS AMPHIPHILES
  申请人：COMMW SCIENT IND RES ORG

  公开号：WO2010063080A1

  公开（公告）日：2010-06-10

  Amphiphilic prodrugs of general formula A-X are disclosed, wherein A is a biologically active agent or may be metabolised to a biologically active agent; and X is selected from the group consisting of R, or up to three R moieties attached to a linker, Y1, Y2 or Y3, wherein R is selected from a group consisting of alkyl, alkenyl, alkynyl, branched alkyl, branched alkenyl, branched alkynyl, substituted alkyl, substituted alkenyl and substituted alkynyl groups and their analogues; Y1 is a linker group which is covalently attached to an R group at one site and is attached to A at a further independent site; Y2 is a linker group which is covalently attached to two R groups at two independent sites and is attached to A at a further independent site; and Y3 is a linker group which is covalently attached to three R groups at three independent sites and is attached to A at a further independent site. Self-assembly of the amphiphilic prodrugs into reverse lyotropic phases, particularly hexagonal, cubic and sponge, is disclosed. In preferred embodiments A is dopamine or a 5- fluorouracil prodrug.
• AMPHIPHILE PRODRUGS
  申请人：NanoMed Holdings Pty Ltd

  公开号：EP2393472B1

  公开（公告）日：2019-06-05