stearic acid-(28-hydroxy-oleanen-(12)-yl-(3β)-ester)

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: stearic acid-(28-hydroxy-oleanen-(12)-yl-(3β)-ester)
• 英文别名: Stearinsaeure-(28-hydroxy-oleanen-(12)-yl-(3β)-ester)；3β-Stearoyloxy-oleanen-(12)-ol-(28)；(4aS)-10c-Stearoyloxy-2.2.6at.6bc.9.9.12ac-heptamethyl-4ar-hydroxymethyl-(8atH.12btH.14bcH)-Δ¹⁴-eicosahydro-picen；[(3S,4aR,6aR,6bS,8aS,12aS,14aR,14bR)-8a-(hydroxymethyl)-4,4,6a,6b,11,11,14b-heptamethyl-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl] octadecanoate
• 化学式: C₄₈H₈₄O₃
• 分子量: 709.193
• InChiKey: FMMUSQQNMWQCLB-XYDRUPMYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  16.5
• 重原子数：
  51
• 可旋转键数：
  19
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  stearic acid-(28-hydroxy-oleanen-(12)-yl-(3β)-ester) 在 sodium methylate 作用下， 以 1,4-二氧六环 、 甲醇 为溶剂， 反应 20.0h， 生成 高根二醇
  参考文献：
  名称：

  Triterpenes, lichexanthone and an acetylenic acid from Minquartia guianensis

  摘要：

  Lichexanthone, 17-hydroxy,9,11,13,15-octadecatetraynoic acid and fatty acid esters (mixture) of erythrodiol (12-oleanene-3,28-diol, 3-beta-form), and betulin (20-(29)-lupen-3,28-diol) were isolated. The structure of the new triterpene, 13,28-epoxy-3-acetoxy-11-oleanene, 3 beta,13 beta form, was determined by X-ray diffraction. The triterpenes occur mainly as C-3-O-palmitates.

  DOI：

  10.1016/s0031-9422(00)94841-6

文献信息

• SOCIOECONOMIC COSTS OF RHEUMATIC DISEASES Implications for Technology Assessment
  作者：Dick Jonsson、Magnus Husberg

  DOI：10.1017/s0266462300103228

  日期：2000.10

  Objectives: To study the socioeconomic impact of rheumatic illness in Sweden and to discuss the consequences for technology assessment studies.Methods: A cost-of-illness study based on data from official statistics and treatment studies.Results: The total socioeconomic cost was 52 billion Swedish kronor (SEK) in 1994. The imbalance between direct (10% of total) and indirect costs (90effectiveness of the healthcare sector, the need for new treatment methods, appropriate information systems, and technology assessment studies as well as the institutional arrangements for rehabilitation and basic medical research.Conclusions: A discussion of solutions for financial cooperation between county councils and regional social insurance offices should be considered. The new biotechnological pharmaceuticals will increase the cost for drugs in health care about 20 times, but the total socioeconomic cost for society may remain at the same level due to a decrease of inpatient costs and indirect costs for loss of production as well as a decrease of transfer payments from social insurance. It is unavoidable that the new pharmaceuticals require priority discussions and active resource allocation in health care and in other sectors of society.
• Triterpenes, lichexanthone and an acetylenic acid from Minquartia guianensis
  作者：Hesham R. El-Seedi、Alan C. Hazell、Kurt B.G. Torssell

  DOI：10.1016/s0031-9422(00)94841-6

  日期：1994.3

  Lichexanthone, 17-hydroxy,9,11,13,15-octadecatetraynoic acid and fatty acid esters (mixture) of erythrodiol (12-oleanene-3,28-diol, 3-beta-form), and betulin (20-(29)-lupen-3,28-diol) were isolated. The structure of the new triterpene, 13,28-epoxy-3-acetoxy-11-oleanene, 3 beta,13 beta form, was determined by X-ray diffraction. The triterpenes occur mainly as C-3-O-palmitates.