N-(2-ethoxymethyl-1-{2-methyl-2-[(methylsulfonyl)amino]propyl}-1H-imidazo[4,5-c]quinolin-4-yl)acetamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N-(2-ethoxymethyl-1-{2-methyl-2-[(methylsulfonyl)amino]propyl}-1H-imidazo[4,5-c]quinolin-4-yl)acetamide
• 英文别名: N-[2-(ethoxymethyl)-1-[2-(methanesulfonamido)-2-methylpropyl]imidazo[4,5-c]quinolin-4-yl]acetamide
• 化学式: C₂₀H₂₇N₅O₄S
• 分子量: 433.531
• InChiKey: HSHSYLFLTQMFND-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  30
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  124
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  N-(2-(4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl)-1,1-dimethylethyl)methanesulfonamide 、 乙酸酐 在 三乙胺 、 乙酰氯 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 3.0h， 生成 N-(2-ethoxymethyl-1-{2-methyl-2-[(methylsulfonyl)amino]propyl}-1H-imidazo[4,5-c]quinolin-4-yl)acetamide
  参考文献：
  名称：

  WO2007/30775

  摘要：

  公开号：

文献信息

• Amide and carbamate derivatives of N-{2-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c] quinolin-1-Yl]-1,1-dimethylethyl}methanesulfonamide and methods
  申请人：Kshirsagar Tushar A.

  公开号：US08476292B2

  公开（公告）日：2013-07-02

  Amide and carbamate derivatives N-2-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]-1,1-dimethylethyl}methanesulfonamide, pharmaceutical compositions containing these compounds, methods of making the compounds, and methods of use of these compounds in modulating the immune system, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.

  本文介绍了酰胺和氨基甲酸酯衍生物N- 2- [4-氨基-2-（乙氧甲基）-1H-咪唑[4,5-c]喹啉-1-基] -1,1-二甲基乙基}甲磺酰胺，包含这些化合物的制药组合物，制备这些化合物的方法，以及在调节免疫系统，诱导动物细胞因子生物合成和治疗包括病毒和肿瘤疾病在内的疾病中使用这些化合物的方法。
• Amide and Carbamate Derivatives of N-{2-[4-Amino-2- (Ethoxymethyl)-1H-Imidazo[4,5-c] Quinolin-1-Yl]-1,1-Dimethylethyl} Methanesulfonamide and Methods
  申请人：Kshirsagar Tushar A.

  公开号：US20100317684A1

  公开（公告）日：2010-12-16

  Amide and carbamate derivatives N-2-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin- 1 -yl]-1,1-dimethylethyl}methanesulfonamide, pharmaceutical compositions containing these compounds, methods of making the compounds, and methods of use of these compounds in modulating the immune system, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.

  本发明涉及酰胺和氨基甲酸酯衍生物N-2-[4-氨基-2-(乙氧甲基)-1H-咪唑[4,5-c]喹啉-1-基]-1,1-二甲基乙基}甲磺酰胺，含有这些化合物的制药组合物，制备这些化合物的方法以及利用这些化合物在动物中调节免疫系统、诱导细胞因子生物合成以及治疗包括病毒性和肿瘤性疾病在内的疾病的方法。
• NANOCARRIERS POSSESSING COMPONENTS WITH DIFFERENT RATES OF RELEASE
  申请人：Lipford Grayson B.

  公开号：US20100303850A1

  公开（公告）日：2010-12-02

  This invention relates to compositions, and related methods, of synthetic nanocarriers that comprise immunomodulatory agents and antigens that are differentially released from the synthetic nanocarriers.
• TARGETED SYNTHETIC NANOCARRIERS WITH PH SENSITIVE RELEASE OF IMMUNOMODULATORY AGENTS
  申请人：ZEPP CHARLES

  公开号：US20110020388A1

  公开（公告）日：2011-01-27

  This invention relates to compositions, and related methods, of synthetic nanocarriers that target sites of action in cells, such as antigen presenting cells (APCs), and comprise immunomodulatory agents that dissociate from the synthetic nanocarriers in a pH sensitive manner. Also disclosed are compositions and methods relating to synthetic nanocarriers that encapsulate labile immunomodulatory agents that dissociate from the synthetic nanocarriers in a pH sensitive manner.
• IMMUNOMODULATORY AGENT-POLYMERIC COMPOUNDS
  申请人：ZEPP CHARLES

  公开号：US20110027217A1

  公开（公告）日：2011-02-03

  This invention relates to compositions, and related compounds and methods, of conjugates of immunomodulatory agents and polymers or unit(s) thereof. The conjugates may be contained within synthetic nanocarriers, and the immunomodulatory agents may be released from the synthetic nanocarriers in a pH sensitive manner.