The present invention relates to a method for synthesizing diversely substituted purines starting from a pyrimidine. Formula (I). The method comprises the formation of an amidine group on the pyrimidine by implementing a Vilsmeier type reagent, the functionalization of the pyrimidine with an amine and the cyclization to form the purine nucleus. Optional steps can also be performed in order to further functionalize the molecule. The invention also relates to new purines and new intermediate product.
本发明涉及一种从
嘧啶开始合成多样取代
嘌呤的方法。公式(I)。该方法包括通过实施Vilsmeier型试剂在
嘧啶上形成酰胺基团,用胺对
嘧啶进行官能化,并进行环化以形成
嘌呤核。还可以执行可选步骤以进一步官能化分子。该发明还涉及新的
嘌呤和新的中间产物。