Treatment is symptomatic and supportive. Oils should not be used as either cathartics or dermal cleansing agents, as they increase absorption. Gastric lavage and use of activated charcoal and sodium sulfate are indicated for ingestion. If dermal exposed occurred, contaminated clothes should be removed, and the skin should be thoroughly cleansed with soap and water. Management of seizures in both children and adults is with Valium or phenobarbital. Respiratory depression and even respiratory arrest, especially with concomitant use of Valium and phenobarbital in children, may occur. These drugs preferably should be used only in critical care areas where emergency endotracheal intubation can be performed. /It is recommended/ that epinephrine not be utilized in patients with organochlorine poisoning, as the organochlorines induce myocardial irritability and ventricular arrhythmias may occur. However, dopamine may be necessary in the event of hypotension unresponsive to fluid administration, and epinephrine may be necessary in the event of cardiopulmonary arrest. ... /Organochlorine insecticides/
来源:Hazardous Substances Data Bank (HSDB)
毒理性
解毒与急救
有机氯杀虫剂通过任何途径高度暴露的人员应被观察是否有感觉异常、协调性障碍、言语不清、精神异常和不自主的 motor 活动等警告性症状，这些症状可能预示即将发生癫痫。如果发生癫痫，将受害者置于左侧卧位，头部向下。移开可能造成伤害的家具或其他固体物品。如果颚部运动剧烈，可在牙齿之间放置衬垫的压舌板以保护舌头。尽可能移除假牙和其他可拆卸的牙齿矫正器。吸出口腔和咽部分泌物，并在可能的情况下插入一个口咽气道以保持气道畅通，不被舌头阻塞。尽量减少噪音和任何可能触发癫痫活动的患者操作。通过面罩给予氧气。在任何呼吸受抑制的情况下，通过机械辅助通气维持肺气体交换。/固体有机氯杀虫剂/
Persons exceptionally exposed to organochlorine pesticides by any route should be observed for sensory disturbances, incoordination, speech slurring, mental aberrations, and involuntary motor activity that would warn of imminent convulsions. If convulsions occur, place the victim in the left lateral decubitus position with the head down. Move away furniture or other solid objects that may be a source of injury. If jaw movements are violent, place padded tongue blades between the teeth to protect the tongue. Whenever possible, remove dentures and other removable dental work. Aspirate oral and pharyngeal secretions, and, when possible, insert an oropharyngeal airway to maintain an open passage unobstructed by the tongue. Minimize noise and any manipulation of the patient that may trigger seizure activity. Administer oxygen by mask. Maintain pulmonary gas exchange by mechanically assisted ventilation whenever respiration is depressed. /Solid organochlorine insecticides/
In patients who have been poisoned by organochlorine contamination of skin, clothing, hair and/or eyes, decontamination must proceed concurrently with whatever resuscitative and anticonvulsive measures are necessary to preserve life. Contamination of the eyes should be removed by flushing with copious amounts of clean water. If the pesticide-exposed person remains alert and physically able, a prompt shower and shampoo may be appropriate, provided the patient is carefully observed to insure against sudden appearance of poisoning. If there are any indications of weakness, ataxia, or other neurologic impairment, clothing should be removed and a complete bath and shampoo given while the victim is recumbent, using copious amounts of soap and water. Attendants should wear rubber gloves. Surgical green soap is excellent for this purpose, but ordinary soap is about as good. The possibility of pesticide sequestered under fingernails or in skin folds should not be overlooked. Contaminated clothing should be promptly bagged and not returned until it has been thoroughly laundered. Contaminated leather shoes should be discarded. The possibility that pesticide has contaminated the inside surfaces of gloves, boots, and headgear should be considered. /Solid organochlorine insecticides/
If organochlorine has been ingested in a quantity sufficient to cause poisoning, the stomach and intestine must be emptied, and measures taken to limit toxicant absorption. Because seizure activity may develop rapidly, lavage, with a large bore orogastric tube and with rigorous protection of the airway, is probably preferable. If the victim is convulsing, it is almost always necessary first to control seizures before attempting gastric intubation. The effectiveness of lavage in removing pesticide from the stomach diminishes rapidly with the passage of time. Particularly in poisoning by large doses of organochlorine, monitor pulmonary ventilation carefully to forestall respiratory failure. Assist pulmonary ventilation mechanically with oxygen whenever respiration is depressed. /Solid organochlorine insecticides/
来源:Hazardous Substances Data Bank (HSDB)
吸收、分配和排泄
以不同程度，有机氯化合物从肠道被吸收，同时也可以通过肺和皮肤吸收。/固态有机氯化合物/
In varying degrees, organochlorines are absorbed from the gut and also by the lung and across the skin. /Soild Organochlorines/
...Collected bile from 2 rats dosed iv with radioactive perthane and recovered in 8-hr period 25 and 55%, respectively, of (14)C. When bile samples were combined and given orally to third rat, about 70% of (14)C...in feces and 13% in urine over 3-day period. ... Relatively rapid excretion of metabolites ... compared to parent compound.
Male weanling rats were fed ad libitum until 250 days of age 1 of 3 nutritionally adequate diets with or without addition of 2.80 ppm of mixture composed of DDT, TDE, DDE, lindane, dieldrin and perthane. Between 251 and 300 days of age 1/2 of rats in each group were restricted to 50% of ad libitum food intake. Deposition and mobilization during weight reduction varied with diet and tissue examined.
来源:Hazardous Substances Data Bank (HSDB)
吸收、分配和排泄
在大鼠身上进行的放射性十六烷喂养试验表明，这种物质在体内脂肪中沉积的倾向很小。
... Feeding tests in rats with radioactive perthane indicate little tendency for the material to deposit in body fat.
Compounds of the formula (I) wherein the substituents are as defined in claim 1, useful as a pesticides, especially fungicides.
式(I)的化合物，其中取代基如权利要求1所定义，作为杀虫剂特别是杀菌剂有用。
Thieno-pyrimidine compounds having fungicidal activity
申请人：Brewster Kirkland William
公开号：US20070093498A1
公开（公告）日：2007-04-26
The present invention relates to thieno[2,3-d]-pyrimidine compounds having fungicidal activity.
本发明涉及具有杀真菌活性的噻吩[2,3-d]-嘧啶化合物。
[EN] INSECTICIDAL TRIAZINONE DERIVATIVES<br/>[FR] DÉRIVÉS DE TRIAZINONE INSECTICIDES
申请人：SYNGENTA PARTICIPATIONS AG
公开号：WO2013079350A1
公开（公告）日：2013-06-06
Compounds of the formula (I) or (I'), wherein the substituents are as defined in claim 1, are useful as pesticides.
式(I)或(I')的化合物，其中取代基如权利要求1所定义的那样，可用作杀虫剂。
Novel insecticides
申请人：Syngenta Participations AG
公开号：EP2540718A1
公开（公告）日：2013-01-02
Compounds of formula I
wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts and all stereoisomers and tautomeric forms of the compounds of formula I can be used as insecticides and can be prepared in a manner known per se.
Molecules having pesticidal utility, and intermediates, compositions, and processes, related thereto
申请人：Dow AgroSciences LLC
公开号：US20180279612A1
公开（公告）日：2018-10-04
This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (“Formula One”).
