[(1R,2R,3R,4S)-3-(diphenylphosphino)-1,7,7-trimethylbicyclo[2.2.1]hept-2-yl][di(2-furyl)]phosphine

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: [(1R,2R,3R,4S)-3-(diphenylphosphino)-1,7,7-trimethylbicyclo[2.2.1]hept-2-yl][di(2-furyl)]phosphine
• 英文别名: [(1S,2R,3R,4R)-3-[bis(furan-2-yl)phosphanyl]-4,7,7-trimethyl-2-bicyclo[2.2.1]heptanyl]-diphenylphosphane
• 化学式: C₃₀H₃₂O₂P₂
• 分子量: 486.53
• InChiKey: WFVXPWPSYAUAGI-HDJQEDSCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.2
• 重原子数：
  34
• 可旋转键数：
  6
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  [(1R,2R,3R,4S)-3-(diphenylphosphoryl)-1,7,7-trimethylbicyclo[2.2.1]hept-2-yl][di(2-furyl)]phosphine oxide 在 三氯硅烷 、 三乙胺 作用下， 以 甲苯 为溶剂， 反应 16.0h， 以68%的产率得到[(1R,2R,3R,4S)-3-(diphenylphosphino)-1,7,7-trimethylbicyclo[2.2.1]hept-2-yl][di(2-furyl)]phosphine
  参考文献：
  名称：

  t-BuOK-Mediated Hydrophosphination of Functionalized Alkenes:  A Novel Synthesis of Chiral P,N- and P,P-Ligands

  摘要：

  A novel synthesis of effective chiral P,N- and P,P-ligands has been developed by using a t-BuOK-mediated hydrophosphination of chiral alkenylpyridines and alkenylphosphine oxides. Ir complexes of chiral P,N-ligrands 1 and 3 gave high enantioselectivities for the hydrogenation of (Z)-alpha(acetamido)cinnamate 25 and (E)-1,2-diphenylpropene leading to the hydrogenated products with up to 97% ee.

  DOI：

  10.1021/jo030383u

文献信息

• <i>t</i>-BuOK-Mediated Hydrophosphination of Functionalized Alkenes:  A Novel Synthesis of Chiral P,N- and P,P-Ligands
  作者：Tanasri Bunlaksananusorn、Paul Knochel

  DOI：10.1021/jo030383u

  日期：2004.7.1

  A novel synthesis of effective chiral P,N- and P,P-ligands has been developed by using a t-BuOK-mediated hydrophosphination of chiral alkenylpyridines and alkenylphosphine oxides. Ir complexes of chiral P,N-ligrands 1 and 3 gave high enantioselectivities for the hydrogenation of (Z)-alpha(acetamido)cinnamate 25 and (E)-1,2-diphenylpropene leading to the hydrogenated products with up to 97% ee.