Hexakis(6-O-tert-butyldimethylsilyl)mono-2-O-(5-azidopentyl)-α-cyclodextrin

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Hexakis(6-O-tert-butyldimethylsilyl)mono-2-O-(5-azidopentyl)-α-cyclodextrin
• 英文别名: (1S,3R,5R,6S,8R,10R,11S,13R,15R,16S,18R,20R,21S,23R,25R,26S,28R,30R,31R,32R,33R,34R,35R,36R,37R,38R,39R,40R,41S,42R)-42-(5-azidopentoxy)-5,10,15,20,25,30-hexakis[[tert-butyl(dimethyl)silyl]oxymethyl]-2,4,7,9,12,14,17,19,22,24,27,29-dodecaoxaheptacyclo[26.2.2.23,6.28,11.213,16.218,21.223,26]dotetracontane-31,32,33,34,35,36,37,38,39,40,41-undecol
• 化学式: C₇₇H₁₅₃N₃O₃₀Si₆
• 分子量: 1769.58
• InChiKey: CKPRNUUGMJZBLV-FBYQHWOHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.63
• 重原子数：
  116
• 可旋转键数：
  31
• 环数：
  22.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  412
• 氢给体数：
  11
• 氢受体数：
  32

反应信息

• 作为反应物：
  描述：

  Hexakis(6-O-tert-butyldimethylsilyl)mono-2-O-(5-azidopentyl)-α-cyclodextrin 在 四丁基氟化铵 作用下， 以 四氢呋喃 为溶剂， 反应 2.0h， 以80%的产率得到Mono-2-O-(5-azidopentyl)-α-cyclodextrin
  参考文献：
  名称：

  The Synthesis of Functionalized Cyclodextrins As Scaffolds and Templates for Molecular Diversity, Catalysis, and Inclusion Phenomena

  摘要：

  alpha-, beta- and gamma-cyclodextrins were chemically modified to selectively introduce functionality on the primary and secondary faces. Azido and substituted alkenyl groups were selectively introduced on the primary hydroxy groups to give monosubstituted derivatives. The secondary C-2 hydroxy group was selectively functionalized with allyl, 1-hexenyl, carboxymethyl, and omega-azidoalkyl groups (n: 3, 4, 5) as ethers. The chemically modified cyclodextrins are versatile molecules for use as scaffolds and templates in conjunction with chemical diversity, catalysis, and inclusion phenomena.

  DOI：

  10.1021/jo00120a023
• 作为产物：
  描述：

  苯丙锡-6-(二甲基-叔-丁基甲硅烷基)-α-环糊精 、 1-Iodo-5-azidopentane 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以26%的产率得到Hexakis(6-O-tert-butyldimethylsilyl)mono-2-O-(5-azidopentyl)-α-cyclodextrin
  参考文献：
  名称：

  The Synthesis of Functionalized Cyclodextrins As Scaffolds and Templates for Molecular Diversity, Catalysis, and Inclusion Phenomena

  摘要：

  alpha-, beta- and gamma-cyclodextrins were chemically modified to selectively introduce functionality on the primary and secondary faces. Azido and substituted alkenyl groups were selectively introduced on the primary hydroxy groups to give monosubstituted derivatives. The secondary C-2 hydroxy group was selectively functionalized with allyl, 1-hexenyl, carboxymethyl, and omega-azidoalkyl groups (n: 3, 4, 5) as ethers. The chemically modified cyclodextrins are versatile molecules for use as scaffolds and templates in conjunction with chemical diversity, catalysis, and inclusion phenomena.

  DOI：

  10.1021/jo00120a023

文献信息

• The Synthesis of Functionalized Cyclodextrins As Scaffolds and Templates for Molecular Diversity, Catalysis, and Inclusion Phenomena
  作者：Stephen Hanessian、Aziza Benalil、Craig Laferriere

  DOI：10.1021/jo00120a023

  日期：1995.7

  alpha-, beta- and gamma-cyclodextrins were chemically modified to selectively introduce functionality on the primary and secondary faces. Azido and substituted alkenyl groups were selectively introduced on the primary hydroxy groups to give monosubstituted derivatives. The secondary C-2 hydroxy group was selectively functionalized with allyl, 1-hexenyl, carboxymethyl, and omega-azidoalkyl groups (n: 3, 4, 5) as ethers. The chemically modified cyclodextrins are versatile molecules for use as scaffolds and templates in conjunction with chemical diversity, catalysis, and inclusion phenomena.