6-O-13-cis-retinoyl-1,2:3,4-di-O-isopropylidene-α-D-galactopyranose

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 6-O-13-cis-retinoyl-1,2:3,4-di-O-isopropylidene-α-D-galactopyranose
• 英文别名: [(1S,2R,6R,8R,9S)-4,4,11,11-tetramethyl-3,5,7,10,12-pentaoxatricyclo[7.3.0.02,6]dodecan-8-yl]methyl (2Z,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoate
• 化学式: C₃₂H₄₆O₇
• 分子量: 542.713
• InChiKey: DIFUTLDGSRCBAR-GRXZDPCVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  39
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.66
• 拓扑面积：
  72.4
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  D-吡喃葡萄糖 在 4-二甲氨基吡啶 、 硫酸 、 copper(II) sulfate 、 N,N'-二环己基碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 反应 10.0h， 生成 6-O-13-cis-retinoyl-1,2:3,4-di-O-isopropylidene-α-D-galactopyranose
  参考文献：
  名称：

  Studies on the Synthesis and Antiproliferative Activities of 13‐cis‐Retinoyl Sugar Derivatives

  摘要：

  New retinoyl sugar derivatives of 13-cis-retinoic acid were synthesized in three ways in this paper in order to enhance pharmacal effects, especially antiproliferative activities of 13-cis-retinoic acid. Their structures were confirmed by IR, H-1-NMR, C-13-NMR, and MS spectra and their antiproliferative activities were determined in vitro using human cancer lines. Results showed that some compounds possessed potential antitumor activities.

  DOI：

  10.1080/07328300600966497

文献信息

• Studies on the Synthesis and Antiproliferative Activities of 13‐<i>cis</i>‐Retinoyl Sugar Derivatives
  作者：Jian‐Nan Xiang、Li‐Hui Jiang、Chao‐Yue Chen、Zhi‐ying Fu、Jun‐Fei Duan、Xiao‐Xiao He、Ke‐Min Wang

  DOI：10.1080/07328300600966497

  日期：2006.9.1

  New retinoyl sugar derivatives of 13-cis-retinoic acid were synthesized in three ways in this paper in order to enhance pharmacal effects, especially antiproliferative activities of 13-cis-retinoic acid. Their structures were confirmed by IR, H-1-NMR, C-13-NMR, and MS spectra and their antiproliferative activities were determined in vitro using human cancer lines. Results showed that some compounds possessed potential antitumor activities.