2-amino-3,4-dihydroquinoline

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-amino-3,4-dihydroquinoline
• 英文别名: 3,4-dihydroquinolin-2-amine
• 化学式: C₉H₁₀N₂
• mdl: MFCD00225068
• 分子量: 146.192
• InChiKey: RREBANHDFAXBEZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.222
• 拓扑面积：
  38.4
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  O-ethyl-3,4-dihydrocarbostyryl 在 氨 、 对甲苯磺酸 作用下， 以 甲醇 为溶剂， 反应 6.0h， 以70%的产率得到2-amino-3,4-dihydroquinoline
  参考文献：
  名称：

  摘要：

  DOI：

  10.1023/a:1023918911369

文献信息

• 2-AMINO-QUINOLINE DERIVATIVES USEFUL AS INHIBITORS OF BETA-SECRETASE (BACE)
  申请人：Baxter Ellen

  公开号：US20080194624A1

  公开（公告）日：2008-08-14

  The present invention is directed to 2-amino-quinoline derivatives, pharmaceutical compositions containing them and their use in the treatment of Alzheimer's disease (AD) and related disorders. The compounds of the invention are inhibitors of β-secretase, also known as β-site cleaving enzyme and BACE, BACE1, Asp2 and memapsin2.

  本发明涉及2-氨基喹啉衍生物，含有它们的药物组合物以及它们在治疗阿尔茨海默病（AD）及相关疾病中的应用。该发明的化合物是β-分泌酶的抑制剂，也称为β-位点裂解酶和BACE、BACE1、Asp2和memapsin2。
• 2-AMINO-3,4-DIHYDRO-QUINOLINE DERIVATIVES USEFUL AS INHIBITORS OF BETA-SECRETASE (BACE)
  申请人：Baxter W. Ellen

  公开号：US20070232642A1

  公开（公告）日：2007-10-04

  The present invention is directed to 2-amino-3,4-dihydro-quinoline derivatives, pharmaceutical compositions containing them and their use in the treatment of Alzheimer's disease (AD) and related disorders. The compounds of the invention are inhibitors of β-secretase, also known as β-site cleaving enzyme and BACE, BACE1, Asp2 and memapsin2.

  本发明涉及2-氨基-3,4-二氢喹啉衍生物，包含它们的药物组合物以及它们在治疗阿尔茨海默病（AD）和相关疾病中的应用。该发明的化合物是β-分泌酶的抑制剂，也被称为β-位点裂解酶和BACE、BACE1、Asp2和memapsin2。
• Chichibabin reaction
  申请人：Reilly Industries, Inc.

  公开号：US05003069A1

  公开（公告）日：1991-03-26

  In a Chichibabin amination of a nitrogen-containing heterocyclic base by sodamide in an organic solvent, the improvement comprising conducting the reaction under pressure of at least about 50 psi in the gas phase above the reaction mixture and adding ammonia to the mixture sufficient to produce a partial pressure of ammonia of at least about 5 psi in the gas phase. Preferred temperature and pressure ranges are disclosed, as are catalysts and other preferred steps for practicing the reaction. Significant results are obtained including improved and changed yields from those classically expected in Chichibabin aminations, including new compositions of matter in at least three cases.

  在有机溶剂中通过苏打胺对含氮杂环碱进行Chichibabin胺化反应的改进包括在反应混合物上方的气相中至少施加50 psi的压力，并添加足够的氨到混合物中，使氨在气相中的分压至少达到5 psi。公开了首选的温度和压力范围，以及催化剂和其他实施该反应的首选步骤。取得了显著的结果，包括改善和改变了Chichibabin胺化反应中经典预期的收率，包括至少三种新的物质组成。
• NOVEL 4-AMINO-PYRIDINE DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS
  申请人：Sørensen Ulrik Svane

  公开号：US20100035924A1

  公开（公告）日：2010-02-11

  This invention relates to novel 4-amino-pyridine derivative useful as modulators of small-conductance calcium-activated potassium channels (SK channels). In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.

  本发明涉及一种新型的4-氨基吡啶衍生物，可用作小电导性钙激活钾通道（SK通道）的调节剂。在其他方面，本发明涉及这些化合物在治疗方法中的使用，以及包含本发明化合物的制药组合物。
• COMPOUNDS FOR THE INHIBITION OF INTEGRINS AND USE THEREOF
  申请人：Zischinsky Gunter

  公开号：US20090104116A1

  公开（公告）日：2009-04-23

  The present invention is related to a compound of formula (I), wherein A is a nonaromatic heterocyclic ring, Ar is either absent or phenylene; Ψ is a radical of formula (II), R 2 is a hydrophobic moiety; and G is a radical containing one or more moieties selected from the group consisting of NH, OH and a basic moiety. The compounds are inhibitors of integrins, especially antagonists of the fibronectin receptor alpha5beta1, useful as anti-angiogenic agents.

  本发明涉及式(I)的化合物，其中A为非芳香杂环环，Ar要么不存在要么为苯环；Ψ为式(II)的基团，R2为疏水基团；G为含有NH、OH和碱性基团中的一种或多种基团的基团。该化合物是整合素的抑制剂，特别是纤维连接蛋白受体alpha5beta1的拮抗剂，可用作抗血管生成剂。