乙酸柏木烯酯 | 1405-92-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 中文名称: 乙酸柏木烯酯
• 中文别名: ,8A&alpha；)]-2,3,4,7,8,8A-六氢-3,8,8-三甲基1H-3A,7-亚甲基奥-6-甲醇乙酸
• 英文名称: ((3R,3aS,7R,8aS)-3,8,8-trimethyl-2,3,4,7,8,8a-hexahydro-1H-3a,7-cedarane-6-yl)methyl acetate
• 英文别名: (8aS)-3c,8,8-trimethyl-6-acetoxymethyl-(8arH)-1,2,4,7,8,8a-hexahydro-3H-3at,7t-methano-azulene；(8aS)-3c,8,8-Trimethyl-6-acetoxymethyl-(8arH)-1,2,4,7,8,8a-hexahydro-3H-3at,7t-methano-azulen；O-Acetyl-cedrenol；(3R-(3α,3aβ,7β,8aα))-2,3,4,7,8,8a-hexahydro-3,8,8-trimethyl-1H-3a,7-methanoazulene-6-methyl acetate；cedrenyl acetate；[(1S,2R,5S,7R)-2,6,6-trimethyl-8-tricyclo[5.3.1.01,5]undec-8-enyl]methyl acetate
• CAS: 1405-92-1
• 化学式: C₁₇H₂₆O₂
• 分子量: 262.392
• InChiKey: AICQDCHSUWFHCC-ZUFFMMDNSA-N

物化性质

• 稳定性/保质期：
  1. 化学性质稳定，不易变色。
  2. 在闭合条件下，产品涂抹于兔子皮肤上，观察一天后未发现刺激现象。用8%浓度的凡士林制剂在人体进行封闭性皮肤接触试验，观察两天后也未发现刺激现象。同样剂量的人体最高限量试验未引发过敏反应。

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

制备方法与用途

合成制备方法

柏木烯可以在乙酸酐和二氧化硒的存在下进行氧化得到。

用途

该物质可作为东方型、檀香型、玫瑰麝香型、素心兰型、香薇型、龙涎香型等香型的协调剂或定香剂。由于其稳定且不易变色的特点，在香皂香精中可以大量使用，最高可达20%的比例。它还能与紫罗兰酮、甲基紫罗兰酮、杂薰衣草油、乙酸异龙脑酯以及几种硝基麝香等成分协同作用。在低档香精中可替代乙酸岩兰草酯使用，并且可以与鸢尾凝脂合用，形成流质的鸢尾油。此外，在皮革香精中它能起到减臭和增香的作用；而在烟草香精中则能增加香甜木香的气息并掩盖焦木辣味。

反应信息

• 作为产物：
  描述：

  (-)-α-cedrene 、 乙酸酐 在 selenium(IV) oxide 作用下， 生成 乙酸柏木烯酯
  参考文献：
  名称：

  Presence of bovine leptin in edible commercial milk and infant formula

  摘要：

  Leptin is a hormone secreted by the adipocytes that contribute to the control of energy balance, and circulating leptin levels reflect the amount of adipose tissue in the body, helping to regulate food intake and energy expenditure. Since it has been shown that human milk contains immunoreactive leptin, which is identical to intact human leptin, we decided to investigate the possible presence of immunoreactive bovine leptin in different kinds of common commercial milk. To determine the presence or absence of immunoreactive leptin in bovine milk for human consumption, 81 samples (66 commercial pasteurized milk and 15 artificial formulae for new-born babies) of the most common Spanish commercial types of milk were studied. All samples were evaluated before and after centrifugation, and leptin levels were measured by RIA. Leptin was detected in all sampies and RIA standard curves were not perturbed when centrifuged and non-centrifuged milk replaced the buffer. Mean values of leptin in full-cream, semi-skimmed and skimmed samples, were: 5.7+/-0.3 ng/ml, 4.1+/-0.1 ng/ml, 3.7+/-0.1 ng/ml (significantly different). Leptin values were reduced after centrifugation. A significant correlation was observed between leptin levels and lipid content (p<0.0005, r=0.67) while no correlation was observed with respect to carbohydrate and protein levels. Interestingly, some preparations of infant formulae present very high leptin values reaching up to 18.9 ng/ml. In conclusion, leptin is present in significant and variable concentrations in edible commercial bovine milk, with higher concentrations in infant formula.

  DOI：

  10.1007/bf03345099

文献信息

• Encapsulation of bulky fragrance molecules
  申请人：Takasago International Corporation

  公开号：EP1894603A1

  公开（公告）日：2008-03-05

  The present invention relates to a fragrance composition to be incorporated within core shell capsules preferably formaldehyde melamine and optionally urea capsules in order to reduce fragrance leakage from the capsules on storage in liquid, gel and soft solid household, laundry and personal care products and cosmetics which contain surfactants and/or solvents. The fragrance composition of the invention comprises: I) 60-100% by weight of at least 5 fragrance compounds fragrance compounds. 20-100% by weight of said fragrance compounds being comprised of at least 3 compounds having a molecular weight less than 325 atomic mass units.

  本发明涉及一种掺入芯壳胶囊（最好是甲醛三聚氰胺胶囊，也可以是尿素胶囊）中的香味组合物，以减少液体、凝胶和软固体家用、洗衣和个人护理产品以及含有表面活性剂和/或溶剂的化妆品在储存时香味从胶囊中渗出。 本发明的香味组合物包括 I) 60-100% （按重量计）的至少 5 种香料化合物。按重量计，20-100%的香料化合物由至少 3 种分子量小于 325 原子质量单位的化合物组成。
• Perfume composition with reduced alcohol content
  申请人：Coty Inc.

  公开号：EP2181690A1

  公开（公告）日：2010-05-05

  The invention relates to perfume compositions with high perfume oil content and reduced or no alcohol content of C2-C5 monovalent alcohols, especially ethanol. The compositions comprise a stable transparent or transluscent emulsion with an oil and water phase.

  本发明涉及香水组合物，香水油含量高，C2-C5 一价醇（尤其是乙醇）含量低或不含酒精。这种组合物由稳定的透明或半透明乳液组成，其中包含油相和水相。
• New microcapsules
  申请人：Takasago International Corporation

  公开号：EP2620211A2

  公开（公告）日：2013-07-31

  The present invention relates to a novel microcapsule which is endowed with reduced leakage of encapsulated materials. The microcapsule contains one or more fragrances and is suitable for inclusion in non-edible consumer goods products, laundry products, personal care products and cosmetic products. The microcapsule can be obtained by polymerizing an emulsion so that emulsion droplets are encapsulated into a subsequently cured polymeric shell.

  本发明涉及一种新型微胶囊，它能减少封装材料的泄漏。这种微胶囊含有一种或多种香料，适用于非食用消费品、洗衣产品、个人护理产品和化妆品。微胶囊可以通过聚合乳液来获得，这样乳液液滴就会被封装到随后固化的聚合物外壳中。
• Method to evaluate fragrance compositions
  申请人：The Procter & Gamble Company

  公开号：EP2799864A1

  公开（公告）日：2014-11-05

  The present invention relates to a method to evaluate and profile a fragrance composition according to the associated biometric response in humans to the composition. A group of at least 20 test participants is exposed to at least 3 fragrance compositions and at least 4 biometric Autonomatic Nervous System (ANS) parameters are measured. Partition and random/bootstrap forest statistical analysis methods are applied to create a profiling model.

  本发明涉及一种根据人类对香味组合物的相关生物特征反应来评估和描述香味组合物的方法。一组至少 20 名测试参与者接触至少 3 种香味组合物，并测量至少 4 种生物特征自主神经系统（ANS）参数。应用分区和随机/自举森林统计分析方法来创建分析模型。
• SOLID COMPOSITION COMPRISING FREE AND ENCAPSULATED FRAGRANCES
  申请人：Takasago International Corporation

  公开号：EP3282003A1

  公开（公告）日：2018-02-14

  The present invention relates to a solid composition comprising polyethylene glycol, free and encapsulated fragrance, a salt and optionally a polyalkoxylate. The composition may be in the form of powder, flakes or pellets. The invention also relates to the use of the solid composition in laundry products, fabric softeners or household cleaners.

  本发明涉及一种固体组合物，由聚乙二醇、游离和封装的香料、盐和可选的聚烷氧基化物组成。该组合物可以是粉末、片状或颗粒状。本发明还涉及固体组合物在洗衣产品、织物柔软剂或家用清洁剂中的用途。